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Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research

Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients ’ Brain in a Dish
Mitochondrial diseases are a heterogeneous group of rare genetic disorders that can be caused by mutations in nuclear (nDNA) or mitochondrial DNA (mtDNA). Mutations in mtDNA are associated with several maternally inherited genetic diseases, with mitochondrial dysfunction as a main pathological feature. These diseases, although frequently multisystemic, mainly affect organs that require large amounts of energy such as the brain and the skeletal muscle. In contrast to the difficulty of obtaining neuronal and muscle cell models, the development of induced pluripotent stem cells (iPSCs) has shed light on the study of mitochond...
Source: Frontiers in Genetics - January 12, 2021 Category: Genetics & Stem Cells Source Type: research

The role of Nrf2 in Neural stem/Progenitors cells: from maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease.
Abstract Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but oxidative stress, inflammation and synaptic dysfunction are main hallmarks. Oxidative stress leads to free radical attack on neural cells which contributes to protein misfolding, glia cell activation, mitochondrial dysfunction, impairment of DNA repair system and subsequently cellular death. ...
Source: Ageing Research Reviews - November 10, 2020 Category: Genetics & Stem Cells Authors: Kahroba H, Ramezani B, Maadi H, Sadeghi MR, Jaberie H, Ramezani F Tags: Ageing Res Rev Source Type: research

GSE132857 Transplantation of cranial neural crest-derived pericytes from human pluripotent stem cells promotes functional recovery in a murine model of ischemic stroke
Contributors : Weiqiang Li ; Jiaqi Sun ; Jin Gong ; Yinong Huang ; Andy P XiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHere, human pluripotent stem cells (including hiPSC and hESC) were induced to differentiate to pericytes (PCs) through the intermediate stage of cranial neural crest stem cells (NCSCs). We sequenced mRNA samples at different stages during NCSC-PCs differentiation of human pluripotent stem cells to generate the gene expression profiles of these cells.
Source: GEO: Gene Expression Omnibus - August 14, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Mesenchymal stem cell-derived extracellular vesicle-based therapies protect against coupled degeneration of the central nervous and vascular systems in stroke.
Abstract Stem cell-based treatments have been suggested as promising candidates for stroke. Recently, mesenchymal stem cells (MSCs) have been reported as potential therapeutics for a wide range of diseases. In particular, clinical trial studies have suggested MSCs for stroke therapy. The focus of MSC treatments has been directed towards cell replacement. However, recent research has lately highlighted their paracrine actions. The secretion of extracellular vesicles (EVs) is offered to be the main therapeutic mechanism of MSC therapy. However, EV-based treatments may provide a wider therapeutic window compared to t...
Source: Ageing Research Reviews - June 17, 2020 Category: Genetics & Stem Cells Authors: Rahmani A, Saleki K, Javanmehr N, Khodaparast J, Saadat P, Nouri HR Tags: Ageing Res Rev Source Type: research

GSE120701 Developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows tracing of monocyte function in stroke
Contributors : Yves Werner ; Elvira MassSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMonocyte-derived and tissue-resident macrophages, such as microglia, belong to independent lineages with distinct functions in steady state. During inflammation, however, changes in phenotypes and transcriptional profiles make it difficult to assess their respective roles in pathology. Here, we report that developmentally controlled expression of Cxcr4 by hematopoietic progenitors allows highly specific inducible lineage tracing of hematopoietic stem cell-derived monocytes during inflammation. In t...
Source: GEO: Gene Expression Omnibus - December 31, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

SOD3 overexpression alleviates cerebral ischemia ‐reperfusion injury in rats
ConclusionOur results indicated that MSCs transfected withSOD3 can effectively alleviate cerebral ischemia ‐reperfusion injury in rats.
Source: Molecular Genetics & Genomic Medicine - August 27, 2019 Category: Genetics & Stem Cells Authors: Shuaiqi Sun, Ning Gao, Xiqi Hu, Han Luo, Jun Peng, Ying Xia Tags: ORIGINAL ARTICLE Source Type: research

Intravascular cell therapy in stroke: predicting the future trends.
Abstract This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational succ...
Source: Regenerative Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Cui L, Moisan A, Jolkkonen J Tags: Regen Med Source Type: research

Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio/cerebro-vascular diseases?
Publication date: June 2018Source: Genes & Diseases, Volume 5, Issue 2Author(s): Fei Li, Xiaojing Wu, Qi Zhou, Dennis Weixi ZhuAbstractAt least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells. Although CHIP is known to predispose patients to a higher risk of malignant blood disorders, the recent revelation of its association with higher morbidity and mortality of atherosclerotic cardiovascular disease and ischemic stroke is rather surprising. Two independent research groups publish...
Source: Genes and Diseases - July 10, 2018 Category: Genetics & Stem Cells Source Type: research

Clonal hematopoiesis of indeterminate potential (CHIP): a potential contributor of atherlosclerotic cardio/cerebro-vascular diseases?
Publication date: Available online 12 April 2018 Source:Genes & Diseases Author(s): Fei Li, Xiaojing Wu, Qi Zhou, Dennis Weixi Zhu At least 10% of the elderly population above the age of 70 carry a condition termed clonal hematopoiesis indeterminate potential (CHIP) due to oligoclonal expansion of mutated hematopoietic stem cells. Although CHIP is known to predispose patients to a higher risk of malignant blood disorders, the recent revelation of its association with higher morbidity and mortality of atherosclerotic cardiovascular disease and ischemic stroke is rather surprising. Two independent research groups pu...
Source: Genes and Diseases - April 12, 2018 Category: Genetics & Stem Cells Source Type: research

GSE95853 Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke
Conclusions: These studies provide further evidence for HSPCs as a promising therapeutic strategy in promoting repair following cerebral I/RI, potentially via a MT-1 mechanism.
Source: GEO: Gene Expression Omnibus - February 21, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Stem cell therapies in age-related neurodegenerative diseases and stroke.
Abstract Aging, a complex process associated with various structural, functional and metabolic changes in the brain, is an important risk factor for neurodegenerative diseases and stroke. These diseases share similar neuropathological changes, such as the formation of misfolded proteins, oxidative stress, loss of neurons and synapses, dysfunction of the neurovascular unit (NVU), reduction of self-repair capacity, and motor and/or cognitive deficiencies. In addition to gray matter dysfunction, the plasticity and repair capacity of white matter also decrease with aging and contribute to neurodegenerative diseases. A...
Source: Ageing Research Reviews - November 18, 2016 Category: Genetics & Stem Cells Authors: Wang Y, Ji X, Leak RK, Chen F, Cao G Tags: Ageing Res Rev Source Type: research

Preliminary Reports of Stereotaxic Stem Cell Transplants in Chronic Stroke Patients
Molecular Therapy 24, 1710 (October 2016). doi:10.1038/mt.2016.186 Author: Cesar V Borlongan
Source: Molecular Therapy - November 6, 2016 Category: Genetics & Stem Cells Authors: Cesar V Borlongan Source Type: research

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