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Bone marrow ‐derived myeloid progenitors in the leptomeninges of adult mice
This study identified a heterogeneous population of myeloid progenitors in the leptomeninges of adult mice, which gave rise to all major myelo ‐erythroid lineages in clonogenic assays. Lineage tracing and bone marrow transplantation showed that the progenitors were derived from adult hematopoietic stem cells and most likely continuously replaced via cell trafficking. Their numbers were diminished in the context of neuroinflammation. AbstractAlthough the bone marrow contains most hematopoietic activity during adulthood, hematopoietic stem and progenitor cells can be recovered from various extramedullary sites. Cells with ...
Source: Stem Cells - December 11, 2020 Category: Stem Cells Authors: Tobias Koeniger, Luisa Bell, Anika Mifka, Michael Enders, Valentin Hautmann, Subba Rao Mekala, Philipp Kirchner, Arif B. Ekici, Christian Schulz, Philipp W örsdörfer, Stine Mencl, Christoph Kleinschnitz, Süleyman Ergün, Stefanie Kuerten Tags: Tissue ‐Specific Stem Cells Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Cardiac Complications in the Adult Bone Marrow Transplant Patient
AbstractPurpose of ReviewDue to advancements in oncologic treatment strategies and techniques, the number of survivors who have undergone hematopoetic stem cell transplant (HCT) continues to increase in the United States; this number is projected to reach 502,000 by the year 2030. There is significant interest within the field of cardio-oncology to identify cardiotoxicity and cardiovascular disease in the HCT population. Epidemiologic studies analyzing both short- and long-term cardiovascular effects, risk stratification modeling, cardioprotective strategies, and expert consensus documents for cardiotoxicity surveillance r...
Source: Current Oncology Reports - March 1, 2019 Category: Cancer & Oncology Source Type: research

Induced Pluripotent Stem Cells: The Most Versatile Source for Stem Cell Therapy.
This article describes the advantages and hurdles for the use of induced pluripotent cells as the starting material for a source of replacement cells for regenerative medicine. PMID: 30049501 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - July 23, 2018 Category: Drugs & Pharmacology Authors: Glicksman MA Tags: Clin Ther Source Type: research

Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
This study was undertaken to elucidate the role of macrophage-expressed IL-37 in reducing the production and effects of proinflammatory cytokines, preventing foam cell formation, and reducing the development of atherosclerosis. Expression of human IL-37 was achieved with a macrophage-specific overexpression system, using the CD68 promoter in mouse primary bone marrow-derived macrophages via retroviral transduction. Macrophage IL-37 expression in vitro resulted in decreased mRNA (e.g., IL-1B, IL-6, and IL-12) and secreted protein production (e.g., IL-6, M-CSF, and ICAM-1) of key inflammatory mediators. IL-37 expression also...
Source: Journal of Immunology - October 13, 2017 Category: Allergy & Immunology Authors: McCurdy S, Baumer Y, Toulmin E, Lee BH, Boisvert WA Tags: J Immunol Source Type: research

Health status, late effects and long‐term survivorship of allogeneic bone marrow transplantation: a retrospective study
ConclusionThis study shows that allo‐HSCT patients are living with high burdens of chronic diseases that warrant lifelong surveillance and engagement with healthcare. Structured, multi‐disciplinary care as recommended by published guidelines for allo‐HSCT survivors may reduce long‐term effects and improve their outcomes.
Source: Internal Medicine Journal - February 17, 2014 Category: Internal Medicine Authors: G. Gifford, J. Sim, A. Horne, D. Ma Tags: Original Article Source Type: research

Health Status, Late Effects and Long Term Survivorship of Allogeneic Bone Marrow Transplantation: A Retrospective Study
ConclusionThis study shows that allo‐HSCT recipients are living with high burdens of chronic diseases that warrant lifelong surveillance and engagement with healthcare. Structured, multi‐disciplinary care as recommended by published guidelines for allo‐HSCT survivors may reduce long term effects and improve their outcomes.
Source: Internal Medicine Journal - November 1, 2013 Category: Internal Medicine Authors: Grace Gifford, Joycelyn Sim, Annabel Horne, David Ma Tags: Original Article Source Type: research

Development of psychological and intellectual performance in transplanted sickle cell disease patients: A prospective study from pretransplant period to 5years after HSCT.
CONCLUSION: At the end of follow-up, the patients improved their physical and psychological well-being. This allowed them to build projects for the future and to manifest the desire of becoming an adult. Bone marrow transplantation in this cohort of children with SCD and severe cerebral vasculopathy is associated with improved performance as measured by the Wechsler scale. PMID: 23769628 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - June 11, 2013 Category: Pediatrics Authors: Bockenmeyer J, Chamboredon E, Missud F, Benkerrou M, Holvoët L, Ithier G, Lescoeur B, Yakouben K, Ouachée-Chardin M, Rohrlich PS, Duval M, Baruchel A, Dalle JH Tags: Arch Pediatr Source Type: research

Stem Cells for Cell-Based Therapies
The world of stem cells We know the human body comprises many cell types (e.g., blood cells, skin cells, cervical cells), but we often forget to appreciate that all of these different cell types arose from a single cell—the fertilized egg. A host of sequential, awe-inspiring events occur between the fertilization of an egg and the formation of a new individual: Embryonic stem (ES) cells are also called totipotent cells. The first steps involve making more cells by simple cell division: one cell becomes two cells; two cells become four cells, etc. Each cell of early development is undifferentiated; that is, it is...
Source: ActionBioscience - December 28, 2012 Category: Science Authors: Ali Hochberg Source Type: news