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Prefrontal Cortex Stroke Induces Delayed Impairment in Spatial Memory.
Abstract Stroke is the leading cause of long-term disability. Little is known about the effects of stroke on cognitive deficits. The subtle nature of cognition and its respective domains in areas such as working memory and attention can make this difficult to diagnose and treat. We aimed to establish a model of focal ischemia that targets the prefrontal cortex (PFC) and induce memory impairments. Stroke and sham mice were assessed at one and four-weeks post-stroke on various tests: open-field task to assess activity; grid-walk and cylinder task to assess motor impairments; elevated plus maze to assess anxiety; nov...
Source: Behavioural Brain Research - August 22, 2015 Category: Neurology Authors: Zhou LY, Wright TE, Clarkson AN Tags: Behav Brain Res Source Type: research

A Virtual, Randomized, Control Trial of a Digital Therapeutic for Speech, Language, and Cognitive Intervention in Post-stroke Persons With Aphasia
Conclusions: Overall, this study demonstrates the feasibility of a fully virtual trial for patients with post-stroke aphasia, especially given the ongoing COVID19 pandemic, as well as a safe, tolerable, and efficacious digital therapeutic for language/cognitive rehabilitation.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT04488029.
Source: Frontiers in Neurology - February 12, 2021 Category: Neurology Source Type: research

A systematic review of non-drug interventions to prevent and treat anxiety in people with aphasia after stroke
CONCLUSION: Definitive conclusions about the effectiveness of non-drug interventions for the prevention and/or treatment of anxiety in people with aphasia post-stroke cannot be made. Interventions that may show promise for those with aphasia and symptoms of anxiety include mindfulness meditation, modified cognitive behaviour therapy, unilateral nostril breathing, and the "Enhance Psychological Coping after Stroke" programme. Further high-quality research with better reporting of the inclusion of participants with aphasia and their specific sub-group results are required.Implications for RehabilitationIt is important for re...
Source: Disability and Rehabilitation - June 12, 2021 Category: Rehabilitation Authors: Brooke J Ryan Stephanie M Clunne Caroline J Baker Ciara Shiggins Miranda L Rose Ian I Kneebone Source Type: research

Improving sleep after stroke: A randomised controlled trial of digital cognitive behavioural therapy for insomnia
J Sleep Res. 2023 Jul 5:e13971. doi: 10.1111/jsr.13971. Online ahead of print.ABSTRACTStroke is frequently accompanied by long-term sleep disruption. We therefore aimed to assess the efficacy of digital cognitive behavioural therapy for insomnia to improve sleep after stroke. A parallel group randomised controlled trial was conducted remotely in participant's homes/online. Randomisation was online with minimisation of between-group differences in age and baseline Sleep Condition Indicator-8 score. In total, 86 community-dwelling stroke survivors consented, of whom 84 completed baseline assessments (39 female, mean 5.5 year...
Source: Journal of Sleep Research - July 5, 2023 Category: Sleep Medicine Authors: Melanie K Fleming Tom Smejka Ellie Macey Ramon Luengo-Fernandez Alasdair L Henry Barbara Robinson Simon D Kyle Colin A Espie Heidi Johansen-Berg Source Type: research

An augmented cognitive behavioural therapy for treating post-stroke depression: description of a treatment protocol.
We present a new psychological intervention designed to reduce depressive complaints after stroke. METHOD OF PROTOCOL DEVELOPMENT: This intervention was based on cognitive behavioural therapy principles and was shown feasible in a pilot study. In order to meet the specific needs of stroke patients (concerning both sensori-motor, cognitive, and behavioural problems), we incorporated motivational interviewing, grief resolution, and psycho-education. We emphasised for each session to take into account the cognitive deficits of the patients (i.e. be concrete, accessible, structured, specific, and repeat information). More...
Source: Clinical Rehabilitation - December 1, 2014 Category: Rehabilitation Authors: Kootker JA, Rasquin SM, Smits P, Geurts AC, van Heugten CM, Fasotti L Tags: Clin Rehabil Source Type: research

Combined Therapy for Patients after Ischemic Stroke as a Support of Social Adaptability.
CONCLUSION: The results of the research point to the fact, that combined therapy of robotic, psychomotor and cognitive can have positive effect on, and be suitable as a treatment for patients after ischemic stroke, regarding their productive age. Positive results have been therefore overt among all tested areas. PMID: 32304370 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - April 20, 2020 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Improving sleep and learning in rehabilitation after stroke, part 2 (INSPIRES2): study protocol for a home-based randomised control trial of digital cognitive behavioural therapy (dCBT) for insomnia
Introduction Consolidation of motor skill learning, a key component of rehabilitation post-stroke, is known to be sleep dependent. However, disrupted sleep is highly prevalent after stroke and is often associated with poor motor recovery and quality of life. Previous research has shown that digital cognitive behavioural therapy (dCBT) for insomnia can be effective at improving sleep quality after stroke. Therefore, the aim of this trial is to evaluate the potential for sleep improvement using a dCBT programme, to improve rehabilitation outcomes after stroke. Methods and analysis We will conduct a parallel-arm randomised c...
Source: BMJ Open - April 6, 2023 Category: General Medicine Authors: Weightman, M., Robinson, B., Fallows, R., Henry, A. L., Kyle, S. D., Garratt, E., Pick, A., Teal, R., Ajina, S., Demeyere, N., Espie, C. A., Seymour, B., Johansen-Berg, H., Fleming, M. K. Tags: Open access, Rehabilitation medicine Source Type: research

An Acceptance and Commitment Therapy (ACT)-Based Intervention for an Adult Experiencing Post-Stroke Anxiety and Medically Unexplained Symptoms
To date, there is little support for the use of any psychotherapy to address post-stroke anxiety. Similarly, there have been no trials of acceptance and commitment therapy (ACT) for post-stroke anxiety, but clinician opinion suggests that an ACT approach may be effective in this context. In this case study, a high-functioning younger man with post-stroke anxiety and associated medically unexplained symptoms (chest pain and dizziness) was assessed and treated using an ACT approach. Mediators of change for both ACT (psychological flexibility) and cognitive therapy (illness perceptions) were recorded as were measures of depre...
Source: Clinical Case Studies - February 25, 2015 Category: Psychiatry Authors: Graham, C. D., Gillanders, D., Stuart, S., Gouick, J. Tags: Articles Source Type: research

Caregivers' effects of augmented cognitive-behavioural therapy for post-stroke depressive symptoms in patients: secondary analyses to a randomized controlled trial.
CONCLUSION:: The results suggest that augmented cognitive-behavioural therapy aimed at improving patients' emotional, behavioural and social functioning positively affects some aspects of caregivers' well-being. PMID: 30841744 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - March 6, 2019 Category: Rehabilitation Authors: Kootker JA, van Heugten CM, Kral B, Rasquin SM, Geurts AC, Fasotti L Tags: Clin Rehabil Source Type: research

Effects of virtual reality immersive training with computerized cognitive training on cognitive function and activities of daily living performance in patients with acute stage stroke: A preliminary randomized controlled trial
Conclusion: Virtual reality immersive training might be an affordable approach for cognitive function and activity of daily living performance recovery for patients with acute stroke.
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Treatment of Post-Stroke Depression
We present the reader with the most recent evidence to support pharmacological, psychosocial, and neuromodulation interventions in PSD. We also discuss the relevance of using antidepressants and psychotherapy to prevent PSD and discuss evidence that antidepressant treatment may reduce mortality after stroke.Recent findingsNeuroinflammation and decrease neurogenesis and plasticity may play an important role in the mechanism of PSD. The strongest predictors of PSD are stroke severity, early physical disability, and severity of loss of functioning. Nevertheless, populations at risk for PSD are yet to be identified. Recent met...
Source: Current Treatment Options in Neurology - June 24, 2019 Category: Neurology Source Type: research

Cognitive-and-motor therapy after stroke is not superior to motor and cognitive therapy alone to improve cognitive and motor outcomes: new insights from a meta-analysis
CONCLUSIONS: CMT was not superior to mono-therapies to improve outcomes after stroke. CMT approaches were equally effective suggesting that training that enlists a cognitive load per se, may benefit outcomes. (PROSPERO CRD42020193655).PMID:37295704 | DOI:10.1016/j.apmr.2023.05.010
Source: Health Physics - June 9, 2023 Category: Physics Authors: Elissa Embrechts Dr Thomas B McGuckian Dr Jeffrey M Rogers Prof Chris H Dijkerman Prof Bert Steenbergen Prof Peter H Wilson Associate Prof Tanja C W Nijboer Source Type: research

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