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Total 451 results found since Jan 2013.

The use of a Berlin Heart EXCOR LVAD in a child receiving chemotherapy for Castleman's disease
We present the unique case of a pediatric patient who received chemotherapy for a diagnosis of CD, while mechanically supported with a Berlin EXCOR LVAD secondary to restrictive cardiomyopathy. A four‐yr‐old previously healthy male with restrictive cardiomyopathy required MCS after cardiac arrest but was diagnosed with multicentric CD, a non‐malignant lymphoproliferative disorder fueled by excessive IL‐6 production. Treatment with IL‐6 blockade (tocilizumab) every two wk and methylprednisolone had no effect on his lymph nodes or cardiac function while on temporary RotaFlow. A Berlin LVAD was placed for treatment...
Source: Pediatric Transplantation - December 1, 2014 Category: Transplant Surgery Authors: Tamara O. Thomas, Shanmuganathan Chandrakasan, Maureen O'Brien, John L. Jefferies, Thomas D. Ryan, Ivan Wilmot, Michael L. Baker, Peace C. Madueme, David Morales, Angela Lorts Tags: Case Report Source Type: research

Parenteral anticoagulation in ambulatory patients with cancer.
CONCLUSIONS: Heparin may have a small effect on mortality at 12 months and 24 months. It is associated with a reduction in venous thromboembolism and a likely increase in minor bleeding. Future research should further investigate the survival benefit of different types of anticoagulants in patients with different types and stages of cancer. The decision for a patient with cancer to start heparin therapy for survival benefit should balance the benefits and downsides, and should integrate the patient's values and preferences. PMID: 25491949 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 10, 2014 Category: Journals (General) Authors: Akl EA, Kahale LA, Ballout RA, Barba M, Yosuico VE, van Doormaal FF, Middeldorp S, Bryant A, Schünemann H Tags: Cochrane Database Syst Rev Source Type: research

Totally one-sided: painless unilateral proptosis
An 88-year-old woman’s startling ophthalmologic symptoms were wrongly attributed to infection during an outpatient examination. When treatment offered no improvement, she presented to Johns Hopkins Hospital, where she reported progressive left eye swelling of 2 weeks’ duration. Seven years earlier, she had undergone mastectomy, chemotherapy, and radiation for breast cancer. Her medical history was also significant for a prior stroke, hypertension, and dementia.
Source: The American Journal of Medicine - January 5, 2015 Category: Journals (General) Authors: Bharati Kochar, Shannon J.C. Shan, Gobind Anand, S. James Zinreich, Allan C. Gelber Source Type: research

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy.
CONCLUSION: More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs. PMID: 25559803 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - January 5, 2015 Category: Cancer & Oncology Authors: Koppelmans V, Vernooij MW, Boogerd W, Seynaeve C, Ikram MA, Breteler MM, Schagen SB Tags: J Clin Oncol Source Type: research

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy Breast Cancer
Conclusion More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs.
Source: Journal of Clinical Oncology - February 18, 2015 Category: Cancer & Oncology Authors: Koppelmans, Vernooij, Boogerd, Seynaeve, Ikram, Breteler, Schagen Tags: Radiation, Chemotherapy Breast Cancer Source Type: research

Temozolomide in low-grade gliomas: living longer and better
Low-grade gliomas (LGGs) account for about a third of gliomas overall and 15% of all primary brain tumours. In adults, the majority of LGGs are WHO Grade II astrocytomas and oligodendrogliomas, which differ in molecular fingerprints and median survival, but share a propensity to malignant transformation after a number of years. Up to 90% of LGGs present with seizures and epilepsy may be the only symptom for many years, significantly impairing quality of life and impacting on social and professional functioning.1 In about 50% of cases, the epilepsy is refractory to antiepileptic drugs (AEDs) with a quarter of patients requi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2015 Category: Neurosurgery Authors: Rees, J. Tags: Immunology (including allergy), Epilepsy and seizures, Neurooncology, Stroke, CNS cancer, Radiology, Surgical oncology Editorial commentaries Source Type: research

Seizure reduction in a low-grade glioma: more than a beneficial side effect of temozolomide
Conclusions TMZ may contribute to an important reduction in seizure frequency in patients with LGG. Seizure reduction following TMZ treatment has prognostic significance and may serve as an important clinical outcome measure in patients with LGG.
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2015 Category: Neurosurgery Authors: Koekkoek, J. A. F., Dirven, L., Heimans, J. J., Postma, T. J., Vos, M. J., Reijneveld, J. C., Taphoorn, M. J. B. Tags: Epilepsy and seizures, Neurooncology, Stroke, CNS cancer Neuro-oncology Source Type: research

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases
This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - April 3, 2015 Category: Molecular Biology Source Type: research

Effects of Acupuncture on Neuropathic Pain: A Systematic Review and Meta-analysis (P3.306)
CONCLUSIONS: The majority of trials demonstrate a positive effect of acupuncture over control condition in the treatment of neuropathy. Further more rigorously designed studies are needed to better characterize this effect.Disclosure: Dr. Dimitrova has nothing to disclose. Dr. Murchison has received research support from the National Institute for Neurological Disorders and Stroke. Dr. Oken has received personal compensation for activities with Dr. Willmar Schwabe Pharmaceuticals as a speaker.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dimitrova, A., Murchison, C., Oken, B. Tags: Pain and Palliative Care Source Type: research

The effect of on body composition: A double blind randomized placebo-controlled trial among Iranian postmenopausal women
This study aimed to investigate whether Black cumin powder exerts beneficial effects on body composition among postmenopausal women. In this randomized, double blind, placebo controlled trial 61 menopausal women aged 45–65 years (at least one year after amenorrhea history) who living in Yasuj were recruited. They should not have history of induced menopause following chemotherapy, radiotherapy or surgery; diagnosed cancers; take hormones or anti hypertensive, antihyperlipidemic or diabetic drugs; history of uncontrolled hypertension, myocardial infarction, stroke or have undiagnosed malignancies.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Saadat Parhizkar, Mehdi Akbartabar Toori, Esfandiar Afshoon Tags: P10 Source Type: research

Intraabdominal pressure, cardiac index and vascular resistance during hyperthermic intraperitoneal chemotherapy - a prospective observational study.
CONCLUSIONS: Increased intraabdominal pressure during HIPEC was comparable to pneumoperitoneum. Haemodynamic changes however were opposed with a decrease in SVRI and a compensative increase in CI. Current guidelines for anaesthetic management in patients undergoing HIPEC are mainly based on findings from laparoscopic surgery and should therefore be reconsidered critically. PMID: 25971283 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - May 16, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Targeting the EWS–FLI1 transcription factor in Ewing sarcoma
Conclusions The encouraging clinical benefit observed with the combination and its good tolerability deserves further investigation in Ewing sarcoma.
Source: Cancer Chemotherapy and Pharmacology - May 23, 2015 Category: Cancer & Oncology Source Type: research

Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline-Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients.
Abstract In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up to 6 months of adjuvant Herceptin(®) therapy. Twenty-seven female breast cancer patients with Her-2/-neu overexpression were studied using conventional echocardiography and 2D speckle tracking. These methods were done before anthracycline-embedded chemotherapy, before adjuvant trastuzumab...
Source: Cardiovascular Toxicology - May 29, 2015 Category: Cardiology Authors: Lange SA, Jung J, Jaeck A, Hitschold T, Ebner B Tags: Cardiovasc Toxicol Source Type: research

Definitive chemoradiotherapy for advanced cervical cancer: should it be different in the elderly?
Conclusions Despite advanced age, more than 60% of pts underwent complete CRT treatment. Thus, age should not be the only factor to guide therapeutic decisions in CC. Carboplatin was better tolerated
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - June 20, 2015 Category: OBGYN Source Type: research

Time course of cytokines, hemodynamic and metabolic parameters during hyperthermic intraperitoneal chemotherapy.
CONCLUSION: The most significant variations are those of IL-6 and PCT. The cytokines level parallel the hemodynamic derangements. Treatment during HIPEC should mimic the established treatment during sepsis and septic shock. PMID: 26154446 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - July 13, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research