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Total 451 results found since Jan 2013.

Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia
AbstractSurgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Unfortunately, these processes are also associated with tumorigenic side-effects. An increasing amount of evidence indicates that the response to a surgery-related brain injury is hijacked by residual glioma cells and participates in the local regeneration of tumor ti...
Source: Journal of Neuro-Oncology - May 17, 2017 Category: Cancer & Oncology Source Type: research

Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India
Conclusions: IAC is an effective therapy for globe preservation in eyes with intraocular RB, in the setting of a developing country like India. Larger studies with longer follow-up are required to validate these results.
Source: Indian Journal of Ophthalmology - May 17, 2017 Category: Opthalmology Authors: Pukhraj Rishi Tarun Sharma Minal Sharma Aditya Maitray Abhinav Dhami Vishvesh Aggarwal Saravanan Munusamy R Ravikumar Satheesh Ramamurthy Source Type: research

MassDevice.com +5 | The top 5 medtech stories for May 19, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. The key components of a well-designed wearable: Sense, analyze, act One of the earliest uses of a wearable technology was recorded during Emperor Nero’s rule over the Roman Empire from 54 to 68 AD. A brutal leader, the empero...
Source: Mass Device - May 19, 2017 Category: Medical Devices Authors: MassDevice Tags: News Well Plus 5 Source Type: news

The Global End-Diastolic Volume (GEDV) Could Be More Appropiate to Fluid Management Than Central Venous Pressure (CVP) During Closed Hyperthermic Intrabdominal Chemotherapy with CO2 Circulation.
CONCLUSIONS: Closed intrabdominal chemotherapy with CO2 circulation model may be a safe model for HIPEC by means of a gas exchanger. GEDV and its changes significantly correlated to CI, and not observed for CVP. GEDV values may be more appropriate for monitoring cardiac preload, blood loss limitation and to predict changes in intravascular volume status during intraperitoneal chemotherapy. PMID: 28557569 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - June 1, 2017 Category: Surgery Tags: J Invest Surg Source Type: research

Reduced-volume radiotherapy for patients with localized intracranial nongerminoma germ cell tumors
We examined outcomes of NGGCT patients receiving reduced-volume RT at a single institution. Records of 16 patients who received reduced-volume RT as part of definitive treatment between 1996 and 2016 were reviewed. Median age at presentation was 10.8 years (range 4.6 –41.0 years). Ten patients had pineal tumors and 6 had suprasellar tumors. All received chemotherapy and 9 patients received second-look surgery thereafter. RT volume was tumor-only to a median of 54 Gy (range 50.4–54 Gy) in 3 patients and whole-ventricle irradiation to a median of 30.6 Gy (r ange 30.6–36 Gy) with a boost to 54 Gy in 13 patients. Me...
Source: Journal of Neuro-Oncology - June 28, 2017 Category: Cancer & Oncology Source Type: research

Association of cancer and Alzheimer's disease risk in a national cohort of veterans
Discussion Survivors of some cancers have a lower risk of AD but not other age-related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 13, 2017 Category: Geriatrics Source Type: research

Association of cancer and Alzheimer's disease risk in a national cohort of veterans.
DISCUSSION: Survivors of some cancers have a lower risk of AD but not other age-related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD. PMID: 28711346 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - July 19, 2017 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Juvenile melanomas: Western Australian Melanoma Advisory Service experience
ConclusionsJuvenile melanoma remains a rarity in Western Australia despite a very high incidence of adult melanoma. Unlike in adults, no definitive risk factors have been established. A significant proportion of this cohort had a pre‐existing naevus and while most melanomas occurred in sun‐exposed areas in light‐skinned individuals the association between sunburn and melanoma was not strong.
Source: Australasian Journal of Dermatology - May 1, 2017 Category: Dermatology Authors: Jie Xin Xu, Sharnice Koek, Samantha Lee, Mark Hanikeri, Mark Lee, Trevor Beer, Christobel Saunders Tags: Original Research Source Type: research

Juvenile melanomas: Western Australian Melanoma Advisory Service experience.
CONCLUSIONS: Juvenile melanoma remains a rarity in Western Australia despite a very high incidence of adult melanoma. Unlike in adults, no definitive risk factors have been established. A significant proportion of this cohort had a pre-existing naevus and while most melanomas occurred in sun-exposed areas in light-skinned individuals the association between sunburn and melanoma was not strong. PMID: 28809039 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - August 15, 2017 Category: Dermatology Authors: Xu JX, Koek S, Lee S, Hanikeri M, Lee M, Beer T, Saunders C Tags: Australas J Dermatol Source Type: research

Nivolumab-induced posterior reversible encephalopathy syndrome
A 47-year-old woman with metastatic, poorly differentiated lung cancer with neuroendocrine features was brought to the hospital after 4 days of nausea, vomiting, disorientation, and 1 generalized tonic clonic seizure. On examination, her blood pressure was 148/95 mm Hg, heart rate 95 bpm, and temperature 36.4°C. She was encephalopathic and had cortical blindness. She had no history of seizures or visual impairment. MRI brain without contrast showed changes consistent with posterior reversible encephalopathy syndrome (PRES; figure, A). She had been on nivolumab, of which she had received 2 doses; the last dose was 24 da...
Source: Neurology Clinical Practice - October 16, 2017 Category: Neurology Authors: Hussein, H. M., Dornfeld, B., Schneider, D. J. Tags: MRI, Other cerebrovascular disease/ Stroke, All Clinical Neurology, Chemotherapy-tumor Case Source Type: research

A Case of ALL Developing Posterior Reversible Encephalopathy Secondary to Hyponatremia
We describe a case of acute lymphoblastic leukemia in which PRES developed secondary to hyponatremia despite being normotensive during receipt of chemotherapy. Magnetic resonance imaging findings were suggestive of PRES. Partial diffusion restriction was observed in lesions in the bilateral occipitoparietal regions and the cerebellum. The patient was treated with appropriate medications with the resolution of his stroke-like symptoms. No neurological deficit was observed and clinical condition improved. The patient continued with chemotherapy. Early diagnosis and treatment of this syndrome is important in terms of preventi...
Source: Journal of Pediatric Hematology Oncology - October 26, 2017 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan Hospital experience.
Conclusion SOAC is a safe technique with a very low complication rate. PMID: 29119878 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - November 10, 2017 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Change in pulmonary function and cardiorespiratory fitness following chemotherapy in testicular cancer patients - a pilot study
Conclusions: There was a substantial reduction in VO2max after BEP corresponding to three decades of physiological aging. This reduction may reflect a decrease in the patients’ cardiac function and oxygen carrying capacity, and not to reduced DLco.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Edvardsen, E., Larsen, K.-O., Fossa, S. D., Ikdahl, T., Loge, J. H., Thorsen, L. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

New-Onset Cardiovascular Morbidity in Older Adults With Stage I to III Colorectal Cancer.
Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity. PMID: 29337636 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - January 16, 2018 Category: Cancer & Oncology Authors: Kenzik KM, Balentine C, Richman J, Kilgore M, Bhatia S, Williams GR Tags: J Clin Oncol Source Type: research

Assessment of Left Ventricular Function by Echocardiography: The Case for Routinely Adding Global Longitudinal Strain to Ejection Fraction
Abstract Left ventricular (LV) ejection fraction (LVEF) is a simple measure of global systolic function that pervades the risk evaluation and management of many cardiovascular diseases. However, this parameter is limited not only by technical challenges, but also by pathophysiological entities where the ratio of stroke volume to LV cavity size is preserved. The assessment of global longitudinal strain (GLS) from speckle-tracking analysis of 2-dimensional echocardiography has become a clinically feasible alternative to LVEF for the measurement of myocardial function. Evidence gathered over the last decade has shown GLS...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 5, 2018 Category: Radiology Authors: Potter, E., Marwick, T. H. Tags: MOC Source Type: research