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Specialty: Cardiology
Nutrition: Sodium Chloride

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Total 85 results found since Jan 2013.

Impact of angiotensin-converting enzyme inhibition on platelet tissue factor expression in stroke-prone rats
Conclusion: The current study shows for the first time that in hypertension the number of TF-positive megakaryocytes increases thus releasing in the circulation more platelets carrying a functionally active TF. AngII stimulates platelets to express TF.
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Cost-effectiveness of a Household Salt Substitution Intervention: Findings From 20,995 Participants of the Salt Substitute and Stroke Study (SSaSS)
Conclusions: Replacing regular salt with salt substitute was a cost-saving intervention for the prevention of stroke and improvement of quality of life amongst the SSaSS participants.PMID:35311346 | DOI:10.1161/CIRCULATIONAHA.122.059573
Source: Circulation - March 21, 2022 Category: Cardiology Authors: Ka-Chun Li Liping Huang Maoyi Tian Gian Luca Di Tanna Jie Yu Xinyi Zhang Xuejun Yin Yishu Liu Zhixin Hao Bo Zhou Xiangxian Feng Zhifang Li Jianxin Zhang Jixin Sun Yuhong Zhang Yi Zhao Ruijuan Zhang Yan Yu Nicole Li Lijing L Yan Darwin R Labarthe Paul Elli Source Type: research

A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines
Conclusion: A differential UCP2 expression associates with different degree of renal damage upon Japanese diet in two SHRSR/SHRSP-derived stroke congenic lines through modulation of mitochondrial function, inflammation, and oxidative stress.
Source: Journal of Hypertension - August 3, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research

Effects of dual angiotensin type 1 receptor/neprilysin inhibition vs. angiotensin type 1 receptor inhibition on target organ injury in the stroke-prone spontaneously hypertensive rat
Conclusion: The dual angiotensin II type 1 receptor/neutroendopeptidase inhibition significantly increased atrial natriuretic peptide level and reduced BP. Complete prevention of stroke was achieved in this model. The ability of sacubitril/valsartan to reduce organ damage progression was superior to that of valsartan alone. ARNi may represent a highly effective therapeutic agent to protect from target organ damage development in hypertension.
Source: Journal of Hypertension - September 1, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Treatment Source Type: research

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)
Publication date: Available online 7 January 2020Source: American Heart JournalAuthor(s): Liping Huang, Maoyi Tian, Jie Yu, Qiang Li, Yishu Liu, Xuejun Yin, Jason HY Wu, Matti Marklund, Yangfeng Wu, Nicole Li, Paul Elliot, Lijing L. Yan, Darwin R. Labarthe, Zhixin Hao, Jingpu Shi, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Bo ZhouAbstractThe Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural Chin...
Source: American Heart Journal - January 7, 2020 Category: Cardiology Source Type: research

Salt Substitute Reduces Stroke, CV Events, and Death Salt Substitute Reduces Stroke, CV Events, and Death
Switching from regular salt to a low-sodium salt substitute has major public health benefits, including a reduction in stroke, cardiovascular events, and death, the new landmark SSaSS shows.Medscape Medical News
Source: Medscape Cardiology Headlines - August 29, 2021 Category: Cardiology Tags: Cardiology News Source Type: news

Fenofibrate attenuates cardiac and renal alterations in young salt-loaded spontaneously hypertensive stroke-prone rats through mitochondrial protection
Conclusion: The results suggest that the cardiorenal protective effects of fenofibrate in young male salt-loaded SHRSPs are explained by its capacity to preserve mitochondrial function.
Source: Journal of Hypertension - March 27, 2018 Category: Cardiology Tags: ORIGINAL PAPERS: Pathophysiological aspects Source Type: research

Effectiveness of butylphthalide on cerebral autoregulation in ischemic stroke patients with large artery atherosclerosis (EBCAS study): A randomized, controlled, multicenter trial
J Cereb Blood Flow Metab. 2023 Apr 6:271678X231168507. doi: 10.1177/0271678X231168507. Online ahead of print.ABSTRACTFinding appropriate drugs to improve cerebral autoregulation (CA) in patients with acute ischemic stroke (AIS) is necessary to improve prognosis. We aimed to investigate the effect of butylphthalide on CA in patients with AIS. In this randomized controlled trial, 99 patients were 2:1 randomized to butylphthalide or placebo group. The butylphthalide group received intravenous infusion with a preconfigured butylphthalide-sodium chloride solution for 14 days and an oral butylphthalide capsule for additional 76 ...
Source: Atherosclerosis - April 6, 2023 Category: Cardiology Authors: Zhen-Ni Guo Bing-Hong Yue Lei Fan Jie Liu Yuanyuan Zhu Yuanqi Zhao Jingxin Zhong Zhan Lou Xing-Liang Liu Reziya Abuduxukuer Peng Zhang Yang Qu Ziduo Shen Baoyang Shi Ke-Jia Zhang Jia Liu Junlei Chang Hang Jin Xin Sun Yi Yang Source Type: research

Dietary potassium: A key mediator of the cardiovascular response to dietary sodium chloride
Abstract: Potassium and sodium share a yin/yang relationship in the regulation of blood pressure (BP). BP is directly associated with the total body sodium and negatively correlated with the total body potassium. Epidemiologic, experimental, and clinical studies have shown that potassium is a significant regulator of BP and further improves cardiovascular outcomes. Hypertensive cardiovascular damage, stroke, and stroke-related death are accelerated by salt intake but might be curbed by increasing dietary potassium intake. The antihypertensive effect of potassium supplementation appears to occur through several mechanisms t...
Source: Journal of the American Society of Hypertension - June 3, 2013 Category: Cardiology Authors: Mehmet Kanbay, Yeter Bayram, Yalcin Solak, Paul W. Sanders Tags: Review Articles Source Type: research

Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
CONCLUSION: Our findings suggest that chronic H2 gas inhalation may help prevent LV hypertrophy in hypertensive DS rats. PMID: 29902079 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - June 14, 2018 Category: Cardiology Authors: Matsuoka H, Miyata S, Okumura N, Watanabe T, Hashimoto K, Nagahara M, Kato K, Sobue S, Takeda K, Ichihara M, Iwamoto T, Noda A Tags: Clin Exp Hypertens Source Type: research

Hypertension and brachydactyly syndrome associated with vertebral artery malformation caused by a PDE3A missense mutation.
CONCLUSIONS: Genetic screening can significantly improve the diagnosis of HTNB patients at an early age. Our study not only adds to the spectrum of PDE3A mutations in the Chinese population and extends the phenotype of HTNB patients to include vertebral malformation but also improves the awareness of pathogenesis in HTNB patients. We emphasize the importance of antihypertensive treatment and long term follow-up to prevent stroke and adverse cardiovascular events. PMID: 31549136 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - September 23, 2019 Category: Cardiology Authors: Fan P, Zhang D, Yang KQ, Zhang QY, Luo F, Lou Y, Liu YX, Zhang HM, Song L, Cai J, Wu HY, Zhou XL Tags: Am J Hypertens Source Type: research

Metabolomic Identification of a Novel Pathway of Blood Pressure Regulation Involving Hexadecanedioate Metabolomics
High blood pressure is a major contributor to the global burden of disease and discovering novel causal pathways of blood pressure regulation has been challenging. We tested blood pressure associations with 280 fasting blood metabolites in 3980 TwinsUK females. Survival analysis for all-cause mortality was performed on significant independent metabolites (P<8.9x10–5). Replication was conducted in 2 independent cohorts KORA (n=1494) and Hertfordshire (n=1515). Three independent animal experiments were performed to establish causality: (1) blood pressure change after increasing circulating metabolite levels in Wista...
Source: Hypertension - July 8, 2015 Category: Cardiology Authors: Menni, C., Graham, D., Kastenmuller, G., Alharbi, N. H. J., Alsanosi, S. M., McBride, M., Mangino, M., Titcombe, P., Shin, S.-Y., Psatha, M., Geisendorfer, T., Huber, A., Peters, A., Wang-Sattler, R., Xu, T., Brosnan, M. J., Trimmer, J., Reichel, C., Mohn Tags: Clinical Studies Metabolomics Source Type: research

High Salt Intake: Independent Risk Factor for Obesity? Salt Intake
High salt intake is the major cause of raised blood pressure and accordingly leads to cardiovascular diseases. Recently, it has been shown that high salt intake is associated with an increased risk of obesity through sugar-sweetened beverage consumption. Increasing evidence also suggests a direct link. Our study aimed to determine whether there was a direct association between salt intake and obesity independent of energy intake. We analyzed the data from the rolling cross-sectional study–the UK National Diet and Nutrition Survey 2008/2009 to 2011/2012. We included 458 children (52% boys; age, 10±4 years) and ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Ma, Y., He, F. J., MacGregor, G. A. Tags: Cerebrovascular disease/stroke, Other hypertension Salt Intake Source Type: research

Controlling hypertension and reducing its associated morbidity and mortality in the Caribbean: implications of race and ethnicity
This article focuses on potential racial and ethnic differences in influences on the pathophysiology of hypertension in the Caribbean region of the world. The identification of such differences may be used in the development of population hypertension control strategies and treatment approach that address the excess disease burden in these populations. The consideration of strategies, such as salt reduction and hypertension awareness and treatment, are particularly relevant to the high‐risk Caribbean region.
Source: The Journal of Clinical Hypertension - July 1, 2017 Category: Cardiology Authors: Paige Colgrove, Kenneth L. Connell, Daniel T. Lackland, Pedro Ordunez, Donald J. DiPette Tags: ORIGINAL PAPER Source Type: research