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Specialty: Biology
Condition: Alzheimer's
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Total 24 results found since Jan 2013.
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med. 2022 Nov 14:S0891-5849(22)00983-2. doi: 10.1016/j.freeradbiomed.2022.11.020. Online ahead of print.ABSTRACTOxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and to induction of neurogenesis after stroke and in prion disease. Here, we generated a novel AD mouse mod...
Source: Free Radical Biology and Medicine - November 17, 2022 Category: Biology Authors: Milena A Egiazarian Silje Str ømstad Teri Sakshaug Ana B Nunez-Nescolarde Nicole Bethge Magnar Bj ørås Katja Scheffler Source Type: research
Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants
ConclusionWomen with CVD were 1.5 times more likely to experience AD than men, while had 15% lower risk of having VD than men.
Source: Biology of Sex Differences - May 7, 2022 Category: Biology Source Type: research
Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease
Free Radic Biol Med. 2022 Feb 21:S0891-5849(22)00073-9. doi: 10.1016/j.freeradbiomed.2022.02.020. Online ahead of print.ABSTRACTAstrocytes play key roles in CNS development as well as well as neuro-supportive roles in the mature brain including ionic, bioenergetic and redox homeostasis. Astrocytes undergo rapid changes following acute CNS insults such as stroke or traumatic brain injury, but are also profoundly altered in chronic neurodegenerative conditions such as Alzheimer's disease. While disease-altered astrocytes are often referred to as reactive, this does not represent a single cellular state or group of states, bu...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Zoeb Jiwaji Giles E Hardingham Source Type: research
A cross-sectional study of blood selenium concentration and cognitive function in elderly Americans: National Health and Nutrition Examination Survey 2011-2014.
Conclusions: Higher blood selenium is associated with higher cognitive scores in elderly Americans.
PMID: 33050724 [PubMed - as supplied by publisher]
Source: Annals of Human Biology - October 21, 2020 Category: Biology Tags: Ann Hum Biol Source Type: research
RNA chemist recognized with $11M 'proven trackrecord' award
(Scripps Research Institute) Scripps Research, Florida Chemistry Professor Matthew Disney, PhD, has been honored with a prestigious Research Program Award from the National Institute of Neurological Disorders and Stroke (NINDS), to aid Disney's development of treatments for incurable diseases such as Alzheimer's, Parkinson's, ALS and frontotemporal dementia.
Source: EurekAlert! - Biology - May 1, 2020 Category: Biology Source Type: news
The Notch pathway in CNS homeostasis and neurodegeneration
This article is categorized under:
Nervous System Development> Flies
Signaling Pathways> Cell Fate Signaling
Nervous System Development> Vertebrates: General Principles
Source: Wiley Interdisciplinary Reviews: Developmental Biology - September 9, 2019 Category: Biology Authors: Diana M. Ho,
Spyros Artavanis ‐Tsakonas,
Angeliki Louvi Tags: FOCUS ARTICLE Source Type: research
Envisioning the neuroprotective effect of Metformin in experimental epilepsy: A portrait of molecular crosstalk
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Nandini H S, Yam Nath Paudel, Krishna K LAbstractEpilepsy is a neurological disorder characterized by an enduring predisposition to generate and aggravate epileptic seizures affecting around 1% of global population making it a serious health concern. Despite the recent advances in epilepsy research, no disease-modifying treatment able to terminate epileptogenesis have been reported yet reflecting the complexity in understanding the disease pathogenesis. To overcome the current treatment gap against epilepsy, one effective approach is to explore ...
Source: Life Sciences - August 8, 2019 Category: Biology Source Type: research
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology
by Yongliang Cao, Haochen Xu, Yuanbo Zhu, Mei-Juan Shi, Lixiang Wei, Jin Zhang, Shuo Cheng, Yiqian Shi, Haiyang Tong, Lijing Kang, Lu Lu, Haiyu Luo, Xing Yang, Xiaofei Bai, Ranran Wang, Yuanyuan Ma, Yun Wang, Zhongfeng Wang, Kai Zhong, Bing-Qiao Zhao, Wenying Fan
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I mo tif, member 13 (ADAMTS13) plays a significant protective effect in...
Source: PLoS Biology: Archived Table of Contents - June 10, 2019 Category: Biology Authors: Yongliang Cao Source Type: research
Shimmer launches Verisense wearable sensor platform for clinical trials
(Rana Healthcare Solutions LLC) Shimmer, a global leader in wearable technology for research applications, today launched Verisense , its next-generation wearable sensor platform designed from the ground up to meet the needs of clinical trial sponsors, sites and participants. Verisense is a comprehensive and flexible solution for reliably capturing accurate and complete biometric data. Starting in March, Shimmer customers are planning to use Verisense in trials for Alzheimer's disease, Parkinson's disease, cancer-related fatigue, and stroke.
Source: EurekAlert! - Biology - February 19, 2019 Category: Biology Source Type: news
NRF2 and NF-қB interplay in Cerebrovascular and Neurodegenerative disorders: Molecular Mechanisms and Possible Therapeutic Approaches
Publication date: Available online 28 November 2018Source: Redox BiologyAuthor(s): Farzane Sivandzade, Shikha Prasad, Aditya Bhalerao, Luca CuculloAbstractElectrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling. However, excessive ROS generation (endogenous and exogenous) can create a state of redox imbalance leading to cellular and tissue damage 1. A growing body of research data strongly suggests that imbalanced ROS and electrophile overproduction are among the major prodromal factors in the onset and progr...
Source: Redox Biology - November 29, 2018 Category: Biology Source Type: research
New gene therapy reprograms brain glial cells into neurons
(Penn State) A new gene therapy can turn certain brain glial cells into functioning neurons, which in turn could help repair the brain after a stroke or during neurological disorders like Alzheimer's or Parkinson's diseases.
Source: EurekAlert! - Biology - November 5, 2018 Category: Biology Source Type: news
NIH scientists search for the clocks behind aging brain disorders
(NIH/National Institute of Neurological Disorders and Stroke) To understand the link between aging and neurodegenerative disorders such as Alzheimer's disease, NIH scientists compared the genetic clocks that tick during the lives of normal and mutant flies. They found that altering the activity of a gene called Cdk5 appeared to make the clocks run faster than normal, and the flies older than their chronological age. This caused the flies to have problems walking or flying later in life, to show signs of neurodegeneration, and to die earlier.
Source: EurekAlert! - Biology - March 14, 2018 Category: Biology Source Type: news
