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Specialty: Biochemistry
Condition: Thrombosis
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Total 44 results found since Jan 2013.
The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular and Cellular Biochemistry - July 3, 2023 Category: Biochemistry Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research
Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23:1-12. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development o...
Source: Molecular and Cellular Biochemistry - March 23, 2023 Category: Biochemistry Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research
Role of oncostatin-M in ECM remodeling and plaque vulnerability
Mol Cell Biochem. 2023 Mar 1. doi: 10.1007/s11010-023-04673-8. Online ahead of print.ABSTRACTAtherosclerosis is a multifactorial inflammatory disease characterized by the development of plaque formation leading to occlusion of the vessel and hypoxia of the tissue supplied by the vessel. Chronic inflammation and altered collagen expression render stable plaque to unstable and increase plaque vulnerability. Thinned and weakened fibrous cap results in plaque rupture and formation of thrombosis and emboli formation leading to acute ischemic events such as stroke and myocardial infarction. Inflammatory mediators including TREM-...
Source: Molecular and Cellular Biochemistry - March 1, 2023 Category: Biochemistry Authors: Parth Patel Vikrant Rai Devendra K Agrawal Source Type: research
Exploring the role of lipoprotein(a) in cardiovascular diseases and diabetes in Chinese population
Int J Biol Macromol. 2023 Feb 7:123586. doi: 10.1016/j.ijbiomac.2023.123586. Online ahead of print.ABSTRACTA high level of lipoprotein (a) in the plasma has been associated with a variety of cardiovascular diseases and is considered to be an independent predictor of some other diseases. Based on recent studies, the concentration levels of Lp(a) in the Chinese population exhibit a distinctive variation from other populations. In the Chinese population, a high level of Lp(a) indicates a higher incidence of revascularization, platelet aggregation, and thrombogenicity following PCI. Increased risk of atherosclerotic cardiovasc...
Source: International Journal of Biological Macromolecules - February 9, 2023 Category: Biochemistry Authors: Zubair Hussain Hongcai Liu Junaid Iqbal Hou-De Zhou Source Type: research
Accurately quantified plasma free glycine concentration as a biomarker in patients with acute ischemic stroke
Amino Acids. 2023 Jan 25. doi: 10.1007/s00726-023-03236-x. Online ahead of print.ABSTRACTWe developed a hollow fiber centrifugal ultrafiltration (HFCF-UF) method to study the change of plasma levels of free glycine (Gly) in patients with acute ischemic stroke (AIS). Twenty-four patients with AIS confirmed by diffusion-weighted imaging (DWI) were enrolled. During the study period, the patients did not receive any supplemental amino acids therapy that could affect the obtained results. Our results showed that although AIS patients adopted different methods of treatment (thrombolytic and non-thrombolytic), the clinical NIHSS ...
Source: Amino Acids - January 25, 2023 Category: Biochemistry Authors: Huan Wang Xiaoyu Ni Weichong Dong Weiman Qin Lei Xu Ye Jiang Source Type: research
TMT proteomics analysis of cerebrospinal fluid from patients with cerebral venous sinus thrombosis
J Proteomics. 2023 Jan 13:104820. doi: 10.1016/j.jprot.2023.104820. Online ahead of print.ABSTRACTCVST is a type of venous stroke that mainly affects young adults with no reliable diagnostic markers and effective treatment strategies for secondary pathologies. However, the underlying pathological molecular mechanisms remain unclear. Here, we systematically analyzed the molecule profiling of the cerebrospinal fluid (CSF) in CVST patients via tandem mass tag (TMT)-based proteomics for the first time, aiming to reveal the pathogenesis and provide evidence for the diagnosis and treatment of CVST. Five CVST patients and five co...
Source: Journal of Proteomics - January 16, 2023 Category: Biochemistry Authors: Yaqi Liu Rui Ding Meng Li Weiyang Ou Xifang Zhang Weijie Yang Xiaofei Huang Huihui Chai Qiujing Wang Source Type: research
Synthesis of novel 3-n-butylphthalide derivatives containing isopentenylphenol moiety as potential anti-platelet agents for the treatment of ischemic stroke
Chem Biodivers. 2022 Nov 24. doi: 10.1002/cbdv.202201002. Online ahead of print.ABSTRACTIn order to find novel anti-platelet drugs for the treatment of ischemic stroke, a series of 3-n-butylphthalide derivatives containing isopentenylphenol moiety were designed, synthesized and characterized with spectroscopic analyses. The in vitro antiplatelet activity results indicated that compound 3 better inhibited the arachidonic acid (AA) induced platelet aggregation than aspirin (ASP) and 3-n-butylphthalide (NBP). Additionally, compared with precursor NBP, compound 3 possessed outstanding antithrombotic activity in the animal expe...
Source: Chemistry and Biodiversity - November 24, 2022 Category: Biochemistry Authors: Qinyang Yu Bilan Luo Zhongfu Luo Xu Zhong Yi Li Yi Zhang Gaofeng Zhu Bing Guo Lei Tang Yong Li Lingling Fan Source Type: research
Neuroprotective, Anti-inflammatory Effect of Furanochrome, Visnagin Against Middle Cerebral Ischemia-Induced Rat Model
In this study, the anti-ischemic effect of a furanochrome visnagin was assessed in in vivo rat model. Middle cerebral ischemic/reperfusion was induced in healthy male Sprague Dawley rats and treated with different concentrations of visnagin. The neuroprotective effect of visnagin against cerebral ischemia-induced rats was assessed by analyzing the neurological score, brain edema, infract volume, and Evans blue leakage. The anti-inflammatory property of visnagin was assessed by quantifying proinflammatory cytokines in serum and brain tissues of cerebral ischemia-induced rats. Prostaglandin E-2, COX-2, and NFκ-β were estim...
Source: Applied Biochemistry and Biotechnology - July 12, 2022 Category: Biochemistry Authors: Qiangyuan Tian Hua Yin Jisen Li Jinggong Jiang Binbin Ren Junhui Liu Source Type: research
Clinical Value of Combined Detection of UA and MMP-9 in Evaluating Bleeding Transformation and Prognosis After Thrombolysis in Acute Cerebral Infarction
Appl Biochem Biotechnol. 2022 Jun 21. doi: 10.1007/s12010-022-03990-w. Online ahead of print.ABSTRACTThis paper presents an in-depth study and analysis of the assessment of hemorrhagic transformation and prognostic outcome after thrombolysis in acute cerebral infarction using a combined test and evaluates its clinical value. The ischemic tissue hemodynamic changes were compared and analyzed by the combined application of magnetic resonance conventional examination. Single-factor and multi-factor Logistic regression analysis was applied to the model group samples to determine the independent influencing factors of hemorrhag...
Source: Applied Biochemistry and Biotechnology - June 21, 2022 Category: Biochemistry Authors: Yaming Fu Shuihong Zheng Huimei Kong Mingqiao Ying Hongfang Chen Jianwei Wang Xiaobo Yuan Source Type: research
