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Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study
Conclusions Our study extends the observations of previously published smaller studies in children with CSVT that this is a morbid disease with diverse underlying causes and risk factors. Divergent treatment practices among highly specialised centres as well as limited data on treatment efficacy and safety suggest that further study of this condition is warranted.
Source: Archives of Disease in Childhood - January 20, 2015 Category: Pediatrics Authors: Ichord, R. N., Benedict, S. L., Chan, A. K., Kirkham, F. J., Nowak-Gottl, U., Ashwal, deVeber, Ferriero, Fullerton, Ichord, Kirkham, Lynch, O'Callaghan, Pavlakis, Sebire, Willan, Kirton, Moharir, Sofronas, Nowak-Gottl, During, Krumpel, Dowling, Plumb, Jou Tags: Epidemiologic studies, Drugs: cardiovascular system, Epilepsy and seizures, Headache (including migraine), Pain (neurology), Stroke, Child health, Memory disorders (psychiatry) Original article Source Type: research

What Are the Classifications of Perinatal Stroke?
Discussion Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Stroke in pediatric ECMO patients: analysis of the National Inpatient Sample (NIS) database
CONCLUSIONS: Over the years, there is an apparent increase in the diagnosis of stroke. All types of stroke in ECMO patients are associated with increased LOS, although mortality is increased in hemorrhagic and combined stroke only.IMPACT: Stroke is a commonly seen complication in pediatric patients supported by ECMO. Understanding the trends will help in identifying modifiable risk factors that predict poor outcomes in this patient population.PMID:35505077 | DOI:10.1038/s41390-022-02088-7
Source: Pediatric Research - May 3, 2022 Category: Pediatrics Authors: Chidiebere Ezetendu Orkun Baloglu Hasan F Othman Vanishree Nandakumar Samir Latifi Hany Aly Source Type: research

Management and 2-year follow-up of children aged 29days to 17years hospitalized for a first stroke in France (2009-2010).
CONCLUSION: This is the first study to report the epidemiology of childhood stroke in France. The validity of this study is supported by the fact that it demonstrated homogeneous descriptive indicators to those obtained by means of various methodologies in other populations. The high mortality, recurrence, and disability rates observed during the year following the initial stroke encourage continuation of the ongoing process of standardizing the management of childhood stroke in France. PMID: 25287139 [PubMed - as supplied by publisher]
Source: Archives de Pediatrie - October 3, 2014 Category: Pediatrics Authors: Tuppin P, Samson S, Woimant F, Chabrier S Tags: Arch Pediatr Source Type: research

West Virginia University Pediatric Stroke Registry: Clinical Description and Risk Factors Identification in Patients From a Rural Area
Conclusion. Patients with the most common risk factors for stroke (cardiac disease) were overrepresented. This suggests that in children receiving medical attention in rural areas less common risk factors for stroke might not be identified, increasing the risk recurrence. Increased index of suspicion is needed about pediatric stroke in rural areas, and early transfer to a tertiary care center for identification of risk factors is mandatory.
Source: Clinical Pediatrics - December 2, 2014 Category: Pediatrics Authors: Pergami, P., Thayapararajah, S. W., Seemaladinne, N. Tags: Articles Source Type: research

Short ‐term neurological outcomes in ischemic and hemorrhagic pediatric stroke
ConclusionsPediatric stroke is associated with poor prognosis in a substantial number of patients in short term, with CSVT having the worst prognosis. Not only ischemic but also hemorrhagic stroke were presented with detailed patient characteristics, with a full thrombosis panel achieved for most ischemic stroke patients.This article is protected by copyright. All rights reserved.
Source: Pediatrics International - November 18, 2018 Category: Pediatrics Authors: Tu ğçe Aksu Uzunhan, Nur Aydinli, Mine Çalişkan, Burak Tatli, Meral Özmen Tags: Original Articles Source Type: research

Antithrombotic Therapy for Secondary Stroke Prevention in Bacterial Meningitis in Children
Conclusion: In this small sample, heparin and ASA appeared to be safe in childhood bacterial meningitis complicated by stroke and may be effective in improving outcome. Heparin may be more effective than aspirin in preventing recurrent infarction.
Source: The Journal of Pediatrics - July 24, 2014 Category: Pediatrics Authors: Cyrus Boelman, Manohar Shroff, Ivanna Yau, Bruce Bjornson, Susan Richrdson, Gabrielle deVeber, Daune MacGregor, Mahendranathn Moharir, Rand Askalan Tags: Original Articles Source Type: research

Malignant Paraganglioma Presenting With Hemorrhagic Stroke in a Child
We report here the case of a 12-year-old boy with malignant sympathetic paraganglioma presenting with hemorrhagic stroke. Severe hypertension was found and the patient evolved into a coma. Brain computed tomography scan showed right thalamus hemorrhage with intraventricular extension. After clinical improvement, further investigation revealed elevated catecholamine and metanephrine levels, and 2 abdominal tumors were identified by computed tomography. Resection of both lesions was performed, and histologic findings were consistent with paraganglioma. Multiple metastatic involvement of bones and soft tissues appeared severa...
Source: PEDIATRICS - December 2, 2013 Category: Pediatrics Authors: Luiz, H. V., da Silva, T. N., Pereira, B. D., Santos, J. G., Goncalves, D., Manita, I., Portugal, J. Tags: Case Report Source Type: research

Current Concepts in Pediatric Stroke
Abstract Stroke is a relatively rare but rather significant cause of short- and long-term morbidity and mortality in children. It can be divided into three categories: arterial ischemic stroke (AIS), hemorrhagic stroke (HS) and cerebral sinovenous thrombosis (CSVT). This review focuses on AIS. The etiologies of pediatric AIS are diverse and different from those in adult stroke, chief among these being congenital heart disease, vasculopathies, hematological disorders and prothrombotic states. Additional factors might be related to the age group, ethnicity and geographic factors. Early recognition enables initiation...
Source: Indian Journal of Pediatrics - November 22, 2014 Category: Pediatrics Source Type: research

Brain attacks and stroke in children
Abstract Emergency physicians are often the first point of contact in children presenting with acute neurological disorders. Differentiating serious disorders, such as stroke, from benign disorders, such as migraine, can be challenging. Clinical assessment influences decision‐making, in particular the need for emergent neuroimaging to confirm diagnosis. This review describes the spectrum of disorders causing ‘brain attack’ symptoms, or acute onset focal neurological dysfunction, with particular emphasis on childhood stroke, because early recognition is essential to improve access to thrombolytic treatments, which hav...
Source: Journal of Paediatrics and Child Health - April 5, 2016 Category: Pediatrics Authors: Mark T Mackay, Paul Monagle, Franz E Babl Tags: Review Article Source Type: research

Tuberous sclerosis presenting with hemorrhagic stroke.
Abstract BACKGROUND: Incidence of intracerebral hemorrhage in patients with tuberous sclerosis is rare, and in most of the cases it is associated with either underlying cerebrovascular malformation or hemorrhage into the subependymal giant cell astrocytoma. CASE CHARACTERISTICS: A 2-year-old boy presented with a hemorrhagic stroke, and subsequently diagnosed as a case of tuberous sclerosis. OBSERVATION: Detailed work-up for stroke did not reveal any definite etiology. OUTCOME: Weakness gradually improved. Follow-up neuroimaging showed resolution of hemorrhage. MESSAGE: Clinician must be aware r...
Source: Indian Pediatrics - April 8, 2014 Category: Pediatrics Authors: Purkait R, Bhattacharya S, Roy B, Bhadra R Tags: Indian Pediatr Source Type: research

Stroke in Acquired and Congenital Heart Disease Patients and Its Relationship to Hospital Mortality and Lasting Neurologic Deficits
Objective: To describe strokes in patients with acquired or congenital heart disease and investigate risk factors for in-hospital mortality and ongoing neurologic deficits. Design: Single-center, retrospective review of cardiac, neurologic, and radiologic patient databases. Setting: Tertiary care children’s hospital. Patients: All patients with acquired or congenital heart disease admitted from January 2010 to October 2014 identified with stroke. Interventions: None. Measurements and Main Results: Eighty-four stroke events were identified in 83 patients (median age, 5.9 mo; interquartile range, 0.8–33.4). Thirty-t...
Source: Pediatric Critical Care Medicine - October 1, 2016 Category: Pediatrics Tags: Neurocritical Care Source Type: research

Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke
Conclusion: Arteriopathy and coagulation activation are highly prevalent in the acute period of childhood AIS. Although recurrent AIS and intracranial hemorrhage were infrequent in our cohort, one-half of children experienced a poor neurologic outcome at 1 year, the risk of which was increased by acute arteriopathy. Substantiation of these findings in multi-institutional cohort studies is warranted, toward risk stratification in childhood-onset AIS.
Source: The Journal of Pediatrics - December 20, 2012 Category: Pediatrics Authors: Neil A. Goldenberg, Sarah Jenkins, Jessica Jack, Jennifer Armstrong-Wells, Laura Z. Fenton, Nicholas V. Stence, Joyce Oleszek, Richard Boada, Greta N. Wilkening, Charles Wilkinson, Jennifer B. Soep, Shelley D. Miyamoto, Lalit Bajaj, Peter M. Mourani, Mari Tags: Original Articles Source Type: research

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