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Total 48 results found since Jan 2013.

Catabolic Signaling and Muscle Wasting After Acute Ischemic Stroke in Mice: Indication for a Stroke-Specific Sarcopenia Basic Sciences
Conclusions— Catabolic pathways of muscle tissue are activated after stroke. Impaired feeding, sympathetic overactivation, or infection cannot fully explain this catabolic activation. Wasting of the target muscle of the disrupted innervation correlated to severity of brain injury. Our data indicate the presence of a stroke-specific sarcopenia.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Springer, J., Schust, S., Peske, K., Tschirner, A., Rex, A., Engel, O., Scherbakov, N., Meisel, A., von Haehling, S., Boschmann, M., Anker, S. D., Dirnagl, U., Doehner, W. Tags: Animal models of human disease, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Body Mass Index and Stroke Subtype in a Young Adult Stroke Population (P7.126)
CONCLUSIONS: In our group of young adult stroke patients, we found the highest BMI in the group with intracranial atherosclerosis. Although this group represented a small number of patients, this young adult population is at increased risk for future strokes. It is important to educate them on lifestyle modifications such as weight loss and exercise in addition to the treatment of hypertension, diabetes mellitus and hyperlipidemia.Disclosure: Dr. Youn has nothing to disclose. Dr. Aung has nothing to disclose. Dr. Afrasiabi has nothing to disclose. Dr. Clark has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Youn, J., Aung, T., Afrasiabi, M., Clark, J. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice
AbstractDuring recovery, stroke patients are at risk of developing long-term complications that impact quality of life, including changes in body weight and composition, depression and anxiety, as well as an increased risk of subsequent vascular events. The aetiologies and time-course of these post-stroke complications have not been extensively studied and are poorly understood. Therefore, we assessed long-term changes in body composition, metabolic markers and behaviour after middle cerebral artery occlusion in mice. These outcomes were also studied in the context of obesity, a common stroke co-morbidity proposed to prote...
Source: Translational Stroke Research - December 20, 2019 Category: Neurology Source Type: research

The Obesity Paradox and Survivors of Ischemic Stroke
Although obesity is a risk factor for stroke and achieving normal weight is advocated to decrease stroke risk, the risk associated with obesity and weight loss after stroke has not been well established. The aim of this study was to assess the association of obesity at the time of stroke admission and weight loss after stroke with total mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - April 9, 2015 Category: Neurology Authors: Peter Wohlfahrt, Francisco Lopez-Jimenez, Alena Krajcoviechova, Marie Jozifova, Otto Mayer, Jiri Vanek, Jan Filipovsky, Ernesto M. Llano, Renata Cifkova Source Type: research

Prognostic importance of weight change on short‐term functional outcome in acute ischemic stroke
ConclusionsShort‐term weight loss after stroke appears to be more common than we expected, and our results suggest that it is associated with unfavorable functional outcomes. Therefore, clinical nutrition should be considered as a component of medical treatment and weight loss should be monitored as an indicator of malnutrition.
Source: International Journal of Stroke - June 29, 2015 Category: Neurology Authors: Yerim Kim, Chi Kyung Kim, Seunguk Jung, Sang‐Bae Ko, Seung‐Hoon Lee, Byung‐Woo Yoon Tags: Research Source Type: research

Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
AbstractDespite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evok...
Source: Translational Stroke Research - December 12, 2022 Category: Neurology Source Type: research

Self-Reported Body Weight Changes, Perceptions, and Weight Loss Techniques among Stroke Survivors
Background: Little is known about the body weight goals and trends of stroke survivors, despite evidence that overweight and obesity can negatively influence poststroke rehabilitation outcomes. Thus, the purpose of this study was to identify self-reported body weight trends over time in stroke survivors and nonstroke controls (>50 years old) and describe the methods used to attempt to achieve body weight goals. Methods: Self-reported body weight 1) at age 25 years, 2) 10 years prior to the current assessment, 3) 1 year prior to the current assessment, 4) current weight, and 5) age of heaviest body weight were collected fro...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Jessica L. Kelleher, Paul Weiss, Amy D. Rodriguez, Joe R. Nocera, Monica C. Serra Source Type: research

A Puzzling Case of Cryptogenic Stroke
Background: Stroke is a common neurological complication of infective endocarditis (IE) and it is associated with increased morbidity and mortality but infective endocarditis in acute stroke setting is hard to discover. Material and methods: A 75-year-old man referred to hospital for the onset of left hemiparesis and dysarthria. His past medical history included hypertension. He had 3 months history of fatigue, fever, and weight loss. Neurological examination revealed left hemiparesis and dysarthria.
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2019 Category: Neurology Authors: Marisa Distefano, Rosalinda Calandrelli, Vincenzo Arena, Alessandro Pedicelli, Giacomo Della Marca, Fabio Pilato Tags: Case Report Source Type: research

Association of Activities of Daily Living with Body Weight Change 3 Months After Stroke Onset
To investigate the relationship between body weight loss and activities of daily living (ADL) 3 months after stroke onset.
Source: Journal of Stroke and Cerebrovascular Diseases - May 23, 2022 Category: Neurology Authors: Takuma Mogamiya, Yoshitsugu Omori, Junichi Kawagoe, Takuto Kaneda, Shinya Matsushima, Hidetaka Onodera Source Type: research

Body Mass Index and Stroke Subtype in a Young Adult Stroke Population (I12-5D)
CONCLUSIONS: In our group of young adult stroke patients, we found the highest BMI in the group with intracranial atherosclerosis. Although this group represented a small number of patients, this young adult population is at increased risk for future strokes. It is important to educate them on lifestyle modifications such as weight loss and exercise in addition to the treatment of hypertension, diabetes mellitus and hyperlipidemia.Disclosure: Dr. Youn has nothing to disclose. Dr. Aung has nothing to disclose. Dr. Afrasiabi has nothing to disclose. Dr. Clark has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Youn, J., Aung, T., Afrasiabi, M., Clark, J. Tags: Obesity and Neurological Disorders Poster Presentations Source Type: research

Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats.
CONCLUSIONS: T2DM-MSC-Exo treatment for stroke in T2DM rats promotes neurorestorative effects and improves functional outcome. Down regulation of miR-9 expression and increasing its target ABCA1 pathway may contribute partially to T2DM-MSC-Exo treatment induced white matter remodeling and anti-inflammatory responses. PMID: 32889008 [PubMed - as supplied by publisher]
Source: Experimental Neurology - August 31, 2020 Category: Neurology Authors: Venkat P, Zacharek A, Landschoot-Ward J, Wang F, Culmone L, Chen Z, Chopp M, Chen J Tags: Exp Neurol Source Type: research

Epigenetic changes in the methylation patterns of KCNQ1 and WT1 after a weight loss intervention program in obese stroke patients.
The objective of this research was to investigate, in obese patients suffering a previous stroke, the effects of a nutritional program on anthropometric and biochemical variables, and on the methylation patterns of two stroke-related genes (KCNQ1: potassium channel, voltage gated KQT-like subfamily Q, member 1; and WT1: Wilms tumor 1). Twenty-two ischemic stroke patients were compared with a control group composed of eighteen obese subjects with similar age and body mass index ranges. Both groups followed a 20-week nutritional program based on an energy-restricted balanced diet with high adherence to the Mediterranean diet...
Source: Current Neurovascular Research - July 31, 2015 Category: Neurology Authors: Abete I, Gomez-Uriz AM, Mansego ML, De Arce A, Goyenechea E, Blazquez V, Martinez-Zabaleta MT, Gonzalez-Muniesa P, De Munain AL, Martinez JA, Campion J, Milagro FI Tags: Curr Neurovasc Res Source Type: research

Creating an appropriate adaptation of a healthy lifestyle intervention for people after stroke.
CONCLUSIONS: Feedback from the diverse group of stakeholders provides the basis for modifying an evidence-based healthy lifestyle intervention to meet the unique needs of people after stroke. Future research efforts should examine the efficacy and effectiveness of the adapted program to prevent weight gain after stroke and reduce the risk of chronic conditions including diabetes, metabolic syndrome, and heart disease. PMID: 32813569 [PubMed - as supplied by publisher]
Source: Brain Injury - August 21, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Weight loss: indication of brain damage and effect of combined normobaric oxygen and ethanol therapy after stroke.
DISCUSSION: Degree of weight loss after stroke is largely associated with severity of infarction as well as damage reduction after treatment administration. PMID: 25819503 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research