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Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study
Conclusions: Lifestyle factors, such as physical activity, sleep, and social activity appear to be associated with cognitive function among older people. Physical activity and appropriate durations of sleep and conversation are important for cognitive function. Introduction Dementia is a major public health issue worldwide, with a serious burden for patients, caregivers, and society, as well as substantial economic impacts (1). Although the prevalence of late-life cognitive impairment and dementia are expected to increase in future, effective disease-modifying treatments are currently unavailable. Therefore, unders...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

The Young Male Syndrome —An Analysis of Sex, Age, Risk Taking and Mortality in Patients With Severe Traumatic Brain Injuries
Conclusion The willingness of young males to engage in dangerous situations might be adaptive in terms of fitness maximization. Nonetheless, for some individuals this intense sexual competition can be detrimental to health. The correspondence between the age distribution of the reproductively most active population and those suffering sTBI only partially supports the evolutionary hypothesis about risk-taking behavior. The prevalence of higher external mortality rates of young males, on the other hand, was not present in our data at all, nor did we find any support for the assumption that sTBI acquired from riskier behavio...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Decompressive Craniectomy for Traumatic Brain Injury: Postoperative TCD Cerebral Hemodynamic Evaluation
Conclusion: There is a wide heterogeneity of postoperative cerebral hemodynamic findings among TBI patients who underwent DC, including hemodynamic heterogeneity between their cerebral hemispheres. DC was proved to be effective for the treatment of cerebral oligoemia. Our data support the concept of heterogeneous nature of the pathophysiology of the TBI and suggest that DC as the sole treatment modality is insufficient. Introduction Decompressive craniectomy (DC) may effectively decrease intracranial pressure (ICP) and increase cerebral perfusion pressure (CPP) in traumatic brain injury (TBI) patients with refracto...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Efficacy of a dynamic orthosis on the upper limbs in the chronic phase of strokes. A longitudinal study.
CONCLUSIONS: Rehabilitation following a stroke improves strength and body activities in the upper limb. The use of a dynamic orthosis can further improve the strength in this limb, but additional research is needed to confirm our results. PMID: 28849862 [PubMed - in process]
Source: Revista de Neurologia - August 30, 2017 Category: Neurology Authors: Gonzalez-Bernal J, de la Fuente-Anuncibay R, Gonzalez-Santos J, Cuesta-Gomez JL, Cubo E Tags: Rev Neurol Source Type: research

Early Palliative Care Consultation Decreases Length of Stay in Severe Stroke Patients (P1.211)
Conclusions:Early PCC in severe stroke patients decreased hospital LOS by 3 days. This may be due to prompt clarification of goals of care and hastened discharge to hospice. Advanced age, poor pre-stroke functional status, and severe post-stroke deficits and disability warrant early PCC. In addition to decreasing LOS, further study is needed to determine whether early PCC also limits futile tests, procedures, and iatrogenic complications. Ultimately, timely identification of PCC candidates may produce higher satisfaction and decreased hospital costs.Disclosure: Dr. Schloss has nothing to disclose. Dr. Tversky has nothing t...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Schloss, E. R., Tversky, S., Katz, J. M., Wright, P. Tags: Pain and Palliative Care Source Type: research

Sexuality and disability, a poorly studied relationship in neurology (P2.199)
Conclusions:Sexual dysfunction was more frequent in patients with chronic neurological diseases. We found a statistically significant relationship between sexual dysfunction and disability. For overall sexual function, the results indicate that women had lower rates of sexual performance for the same degree of disability than menDisclosure: Dr. Nasimbera has nothing to disclose. Dr. Rosales has nothing to disclose. Dr. Quarrachino has nothing to disclose. Dr. Rodriquez has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Nasimbera, A., Rosales, J., Silva, B., Alonso, R., Bohorquez, N., Lepera, S., Garreto, N., Tomoko, A., Garcea, O., Raul, R., Quarrachino, C., Rodriquez, G. Tags: General Neurology: Practice Improvement and Novel Approaches to Care Source Type: research

Safety and Efficacy of IV-tPA Use in Patients 80 Years and Older- A Retrospective Review (P2.305)
Conclusion—We observed no increase in sICH post IV-tPA in patients 80+ when compared to those younger. Higher mortality in those 80+ likely due to baseline disabilities. Within the 80+ group, predictors of mortality and poor outcomes included disabilities prior to hospitalization, prior stroke/TIA, higher NIHSS at admission, sICH post treatment and higher diastolic blood pressure.Disclosure: Dr. Lau has nothing to disclose. Dr. Romero has nothing to disclose. Dr. Kwan has nothing to disclose. Dr. Kase has nothing to disclose. Dr. Babikian has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Lau, H., Romero, J., Kwan, S., Kase, C., Babikian, V. Tags: Acute Therapy: IV t-PA Source Type: research

Assessment of Stroke Knowledge and Attitudes among Riyadh Medical Students: A Cross-sectional Study (P2.303)
CONCLUSIONS: This study demonstrated average medical students’ knowledge of stroke and identified knowledge gaps in different domains of basic stroke knowledge. Stroke education modules should be incorporated into the preclinical curriculum and neurology or stroke clerkships should be mandatory for all students. Emphasizing the high risk of stroke recurrence in patients with minor or transient symptoms is crucial for decreasing the burden of stroke.Disclosure: Dr. Al Zwahmah has received personal compensation in an editorial capacity for Neurosciences Journal.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Alzawahmah, M. Tags: Cerebrovascular Disease and Interventional Neurology: Education and TIA Source Type: research

Evaluation of Sexual Functions of Women with Stroke (P7.157)
CONCLUSIONS:Sexual functions are affected negatively in women with stroke and considered to be associated with increased disability, levels of independence and accompanied depression, and age. Therefore, women with stroke should also be evaluated as to sexual functions during the follow-up.Study Supported by:NoneDisclosure: Dr. Gumus has nothing to disclose. Dr. Yilmaz has nothing to disclose. Dr. Yilmaz has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gumus, H., Yilmaz, H., Yilmaz, S. Tags: Cerebrovascular Disease and Interventional Neurology: Post-Stroke Function Source Type: research

Quality of life and functional outcome in early school-aged children after neonatal stroke: A prospective cohort study.
Abstract BACKGROUND: Quality of life (QoL) is recognized internationally as an efficient tool for evaluating health interventions. To our knowledge, QoL has not been specifically assessed in children after neonatal arterial ischemic stroke (AIS). AIM: To study the QoL of early school-aged children who suffered from neonatal AIS, and QoL correlation to functional outcome. METHOD: We conducted a multicenter prospective cohort study as part of a larger study in full-term newborns with symptomatic AIS. Participating families were sent anonymous QoL questionnaires (QUALIN). Functional outcome was measured usi...
Source: European Journal of Paediatric Neurology - January 25, 2014 Category: Neurology Authors: Darteyre S, Renaud C, Vuillerot C, Presles E, Kossorotoff M, Dinomais M, Lazaro L, Gautheron V, Chabrier S, AVCnn Group Tags: Eur J Paediatr Neurol Source Type: research