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Specialty: Neurology
Condition: Epilepsy
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Total 1226 results found since Jan 2013.
Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research
Reframing Lesional Epilepsy as a Network Disease
The question why some brain lesions cause epilepsy whereas other do not has remained unanswered for the past century. Lesions are the leading identifiable cause of epilepsy in adults, especially in individuals older than 55 years. But, only 6% of those with stroke, 9% of those with intracerebral hemorrhage, and approximately 40% of those with brain tumors have lesional epilepsy. Why do some develop epilepsy whereas others do not?
Source: JAMA Neurology - July 3, 2023 Category: Neurology Source Type: research
Genetics and SUDEP: Challenges and Future Directions
Sudden unexpected death in epilepsy (SUDEP) is an important cause of premature mortality in persons living with epilepsy (PWE) [1 –2]. The incidence of SUDEP in children and adults is equal, approximately 1.2 per 1000-person years [3–5]. SUDEP is the leading cause of epilepsy-related deaths in children and adults with epilepsy [1–2]. Furthermore, next to stroke, SUDEP is the second leading cause of total years of potenti al life lost [6–7]. Although inroads have been made in our understanding of SUDEP, its pathophysiology remains unknown.
Source: Seizure: European Journal of Epilepsy - July 2, 2023 Category: Neurology Authors: Robyn Whitney, Suvasini Sharma, Kevin C. Jones, Rajesh RamachandranNair Tags: Review Source Type: research
The natural history of epilepsy and nonepileptic seizures in Sturge-Weber syndrome: A retrospective case-note review
This study explored the natural history of epileptic and nonepileptic seizures into adulthood in patients with SWS, and their treatment, and investigated whether any clinical factors predict which symptoms a patient will experience during adulthood.METHODS: A retrospective case-note review of a cohort of 26 adults with SWS at the National Hospital for Neurology and Neurosurgery (NHNN). Childhood data were also recorded, where available, to enable review of change/development of symptoms over time.RESULTS: The course of epilepsy showed some improvement in adulthood - seventeen adults continued to have seizures, while six pa...
Source: Epilepsy and Behaviour - June 22, 2023 Category: Neurology Authors: Rhian Male Sofia H Eriksson Source Type: research
Effectiveness and Safety of Lacosamide, A Third-generation Anti-seizure Medication, for Poststroke Seizure and Epilepsy: A Literature Review
Curr Neuropharmacol. 2023 Jun 20. doi: 10.2174/1570159X21666230616114255. Online ahead of print.ABSTRACTAdvances in stroke treatment have resulted in a dramatic reduction in stroke mortality. Nevertheless, poststroke seizures and epilepsy are issues of clinical importance affecting survivors. Additionally, stroke is the most common cause of epilepsy in older adults. Although numerous antiseizure medications exist, studies are needed to provide robust evidence of the efficacy and tolerability of these medicines for treating poststroke seizures and epilepsy. Crucially, the newer generations of antiseizure medications require...
Source: Epilepsy Curr - June 21, 2023 Category: Neurology Authors: Yu-Shiue Chen Ming-Chi Lai Tsang-Shan Chen Yung-Hsin Tseng Ya Jhen Li Chin-Wei Huang Source Type: research
Associations of small vessel disease and acute symptomatic seizures in ischemic stroke patients
CONCLUSION: In this cohort of hospitalized patients with anterior circulation ischemic stroke, CMBs were more likely to be found in patients with ASS than those without ASS, an association that was attenuated when accounting for stroke severity, cortical infarct location, and hemorrhagic transformation. Evaluation of the long-term risk of seizures associated with CMBs and other markers of small vessel disease is warranted.PMID:37329856 | DOI:10.1016/j.yebeh.2023.109233
Source: Epilepsy and Behaviour - June 17, 2023 Category: Neurology Authors: Alain Lekoubou Paddy Ssentongo Jonathon Maffie Kunal Debroy Michelle Kwon Clever Nguyen Matthew Pelton Benjamin Watt Justin Ceasar Nadia Dinunno Vivek Satyasi Andre Pascal Kengne Leonardo Bonilha Vernon M Chinchilli Source Type: research
Analysis of Risk Factors for Epilepsy after Combined Re-Vascularization in Adult Patients with Moyamoya Disease
Conclusions: Pre-operative epilepsy, the location of the bypass recipient artery, new cerebral infarction, hyper-perfusion syndrome, and intra-cranial hemorrhage may have a causal relationship with epilepsy in adult MMD patients. It is suggested that some risk factors could be intervened to reduce the incidence of post-operative epilepsy in MMD patients.
Source: Neurology India - June 15, 2023 Category: Neurology Authors: Erheng Liu Lide Jin Weihua Tao Xueyi Tan Chengyuan Liu Shuai Zhou Shengquan Huang Xiying Qian Jianhua Zhao Xuehua Li Shuaifeng Yang Source Type: research
Epilepsy-Heart Syndrome: Incidence and Clinical Outcomes of Cardiac Complications in patients with Epilepsy
CONCLUSIONS: The large proportions of PWE with active disease that experience CVEs and the poor long-term outcome associated suggest the existence of an 'epilepsy-heart syndrome'.PMID:37295636 | DOI:10.1016/j.cpcardiol.2023.101868
Source: Epilepsy Curr - June 9, 2023 Category: Neurology Authors: Tommaso Bucci Gashirai K Mbizvo Jos é Miguel Rivera-Caravaca Josephine Mayer Anthony G Marson Azmil H Abdul-Rahim Gregory Y H Lip Source Type: research
