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Specialty: Neurology
Condition: Diabetes

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Total 1939 results found since Jan 2013.

Blood pressure trajectory of inpatient stroke rehabilitation patients from the Determining Optimal Post-Stroke Exercise (DOSE) trial over the first 12 months post-stroke
ConclusionBlood pressure increased after inpatient rehabilitation over the first 12 months post-stroke, especially among those with a history of hypertension. The 4-week aerobic gait training intervention did not influence this trajectory.
Source: Frontiers in Neurology - September 19, 2023 Category: Neurology Source Type: research

Predictors of failure of early neurological improvement in early time window following endovascular thrombectomy: a multi-center study
ConclusionDiabetes mellitus history, pre-stroke mRS, longer last known well-to-puncture time, lack of modified thrombolysis in cerebral infarction = 3, and the number of mechanical thrombectomy passes are the predictors of FENI. Future large-scale studies are required to validate these findings.
Source: Frontiers in Neurology - September 14, 2023 Category: Neurology Source Type: research

The emerging role of the gut microbiome in posttraumatic stress disorder
Brain Behav Immun. 2023 Sep 7:S0889-1591(23)00269-6. doi: 10.1016/j.bbi.2023.09.005. Online ahead of print.ABSTRACTPosttraumatic stress disorder (PTSD) occurs in some people following exposure to a terrifying or catastrophic event involving actual/threatened death, serious injury, or sexual violence. PTSD is a common and debilitating mental disorder that imposes a significant burden on individuals, their families, health services, and society. Moreover, PTSD is a risk factor for chronic diseases such as coronary heart disease, stroke, diabetes, as well as premature mortality. Furthermore, PTSD is associated with dysregulat...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: Shanlin Ke Jakob Hartmann Kerry J Ressler Yang-Yu Liu Karestan C Koenen Source Type: research

Strengthening stroke prevention and awareness in the Philippines: a conceptual framework
This article focuses on stroke prevention and awareness in the Philippines, a country grappling with high stroke incidence and limited healthcare resources. The two-pronged approach presented by the authors aims to address the challenges of stroke care by combining community-based prevention and targeted public awareness campaigns. The community-based stroke prevention component involves personalized risk factor assessments and tailored interventions conducted at local health centers. By identifying modifiable risk factors such as hypertension, diabetes, smoking, and elevated cholesterol levels, healthcare professionals ca...
Source: Frontiers in Neurology - August 31, 2023 Category: Neurology Source Type: research

Thrombectomy with and without computed tomography perfusion imaging for large-vessel occlusion stroke in the extended time window: a meta-analysis of randomized clinical trials
ConclusionThese findings suggest that the choice of NCCT ± CTA (without CTP) for the assessment of mechanical thrombectomy within 6–24 h after LVO in the anterior circulation is not significantly different from CTP; instead, the choice of NCCT ± CTA significantly reduces the time from onset to arterial puncture.
Source: Frontiers in Neurology - August 17, 2023 Category: Neurology Source Type: research

Skin capillary amylin deposition resembles brain amylin vasculopathy in rats
Human amylin is a 37 amino-acid pancreatic peptide that forms neuro-toxic aggregates that deposit in the endothelium of brain capillaries of patients with diabetes, potentially contributing to cerebral small vessel ischemic injury. Pathogenic amylin also deposits in the capillary endothelium in other organs, including the skin. The aim of this study was to test the hypothesis that skin capillary amylin deposition correlates with cerebral small vessel amylin deposition, potentially providing a clinically useful marker of cerebral amylin deposition.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2023 Category: Neurology Authors: Saurav Das, Nirmal Verma, Larry B. Goldstein, Florin Despa Source Type: research

Traumatic brain injury and the pathways to cerebral tau accumulation
Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on the structure of tau and its normal physiological functions, including in hibernation and changes throughout the estrus cycle. There are many pathways involved in phosphorylating tau including diabetes, stroke, Alzheimer’s disease (AD), brain injury, aging, and drug use. The common mechanisms for these processes are put into context with changes observed in mild and repetitive mild traumatic brain injury (TBI). The phosphorylation of tau is a part of the progres...
Source: Frontiers in Neurology - August 11, 2023 Category: Neurology Source Type: research

Do not biopsy the MELAS brain
We read with interest the article by Hass et al. on a 67-year-old female with mitochondrial encephalopathy, lactic acidosis, and stroke-like episode (MELAS) syndrome due to the variant m.3243A  > G with a heteroplasmy rate of 10% in blood, which was initially incorrectly identified as progressive supra-nuclear palsy (PSP) [1]. The mtDNA variant manifested itself phenotypically with cognitive impairment, headache, hypoacusis, gait disturbance falls, and diabetes [1]. Her son also suffered from “stroke”, hypoacusis, and seizures [1].
Source: Parkinsonism and Related Disorders - August 9, 2023 Category: Neurology Authors: Josef Finsterer, Sounira Mehri Tags: Correspondence Source Type: research

Left ventricular hypertrophy and left atrial size are associated with ischemic strokes among non-vitamin K antagonist oral anticoagulant users
ConclusionsPrior cerebrovascular events, diabetes, left ventricular hypertrophy, and increased left atrial size are risk factors for developing an IS among NOAC users.
Source: Journal of Neurology - August 7, 2023 Category: Neurology Source Type: research

Monitoring Risk and Preventing Ischemic Stroke in the Very Old
This article examines current guidelines and evidence regarding medical management, lifestyle changes, and psychosocial interactions that can contribute to the primary and secondary prevention of ischemic stroke in the very old.AREAS COVERED: The authors conducted a literature search for ischemic stroke prevention and risk assessment in the elderly via PubMed. Furthermore, they describe current strategies for monitoring risk and preventing ischemic stroke in the elderly population.EXPERT OPINION: Ischemic stroke poses a significant health risk to the elderly, with prevention relying on managing modifiable risk factors such...
Source: Expert Review of Neurotherapeutics - August 4, 2023 Category: Neurology Authors: Mychael Delgardo Grant Rubin Thilan Tudor Anthony J Tang Geoffrey Reeves E Sander Connolly Source Type: research