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Specialty: Neurology
Condition: Diabetes
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Total 1939 results found since Jan 2013.
A Nomogram for Predicting Patent Foramen Ovale-Related Stroke Recurrence
ConclusionsNomogram 1, based on Hcy, hsCRP, and ALB levels, provided a more clinically realistic prognostic prediction for patients with PFO-related stroke. This model could help patients with PFO-related stroke to facilitate personalized prognostic evaluations.
Source: Frontiers in Neurology - June 9, 2022 Category: Neurology Source Type: research
Neuropathology of Pediatric SARS-CoV-2 Infection in the Forensic Setting: Novel Application of Ex Vivo Imaging in Analysis of Brain Microvasculature
We report 8 such cases (4 infants aged 7–36 weeks, 4 children aged 5–15 years). Four underwent ex vivo magnetic resonance neuroimaging, to assist in identification of subtle lesions related to vascular compromise. All infants were found unresponsive (3 in unsafe sleeping conditions); all but 1 had recent rhinitis and/or influenza-like illness (ILI) in the family; 1 had history of sickle cell disease. Ex vivo neuroimaging in 1 case revealed white matter (WM) signal hyperintensity and diffuse exaggeration of perivascular spaces, corresponding microscopically to WM mineralization. Neurohistology in the remaining 3 infants...
Source: Frontiers in Neurology - May 24, 2022 Category: Neurology Source Type: research
Comparison of Stroke Risk Factors Between Symptomatic and Asymptomatic Patients in a North American Moyamoya Disease Cohort
Conclusions: No significant differences in the prevalence of stroke risk factors between MMD cohorts was found, corroborating evidence provided in a recent Japanese-based study. There were no apparent associations between s troke risk factors and interval cerebrovascular events in an asymptomatic group of MMD patients.
Source: Cerebrovascular Diseases Extra - May 19, 2022 Category: Neurology Source Type: research
Impact of Stress Hyperglycemia on Early Neurological Deterioration in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis
ConclusionA higher SHR predicted that patients with severe stress hyperglycemia had higher risks of END and poor functional outcome at discharge after IV-rtPA.
Source: Frontiers in Neurology - May 13, 2022 Category: Neurology Source Type: research
Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice
Diabetes is one of the well-established risk factors of stroke and is associated with a poor outcome in patients with stroke. Previous studies have shown that the expression of neuron restrictive silencer factor (NRSF) is elevated in diabetes as well as ischemic stroke. However, the role of NRSF in regulating an outcome of diabetic ischemic stroke has not been completely understood. Here, we hypothesized that diabetes-induced NRSF elevation can aggravate brain injury and cognition impairment in ischemic stroke. The diabetic ischemic stroke mice model was established by 8 weeks of high-fat-diet feeding and 5 days of strepto...
Source: Frontiers in Neurology - May 13, 2022 Category: Neurology Source Type: research
Can CHA2DS2-VASc and HAS –BLED Foresee the Presence of Cerebral Microbleeds, Lacunar and Non-Lacunar Infarcts in Elderly Patients With Atrial Fibrillation? Data From Strat–AF Study
Anticoagulants reduce embolic risk in atrial fibrillation (AF), despite increasing hemorrhagic risk. In this context, validity of congestive heart failure, hypertension, age ≥ 75 years, diabetes, stroke, vascular disease, age 65–74 years and sex category (CHA2DS2-VASc) and hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/alcohol concomitantly (HAS–BLED) scales, used to respectively evaluate thrombotic and hemorrhagic risks, is incomplete. In patients with AF, brain MRI has led to the increased detection of “asymptomatic”...
Source: Frontiers in Neurology - May 13, 2022 Category: Neurology Source Type: research
Cerebrovascular Disease Profiles of Culturally and Linguistically Diverse Communities in South Western Sydney and New South Wales
Conclusion: Greater rates of TIA/stroke were observed in specific CALD communities, with increased rates of cerebrovascular risk factors. Culturally specific, targeted interventions may bridge health inequalities in cerebrovascular disease.Cerebrovasc Dis
Source: Cerebrovascular Diseases - May 12, 2022 Category: Neurology Source Type: research
Predicting Role of Prestroke Glycemic Variability Estimated by Glycated Albumin for Reperfusion and Prognosis after Endovascular Treatment
Conclusion: GA, reflecting prestroke glycemic variability, could be a reliable parameter for predicting reperfusion rate and acute ischemic stroke outcome in this study.Cerebrovasc Dis
Source: Cerebrovascular Diseases - May 10, 2022 Category: Neurology Source Type: research
Prevalence and In-hospital outcomes of diabetes among acute ischemic stroke patients in china: results from the Chinese Stroke Center Alliance
ConclusionDiabetes was highly prevalent among AIS patients in China and associated with worse in-hospital outcomes. Greater efforts to increase targeted approach to secondary prevention treatments of diabetes in AIS patients are warranted.
Source: Journal of Neurology - May 5, 2022 Category: Neurology Source Type: research
Pattern and Severity of Leukoaraiosis and Microvascular Resistance- Inputs from a TCD Study from South Asia
Conclusions: Our study confirms the correlation of Pulsatility Index with leukoaraiosis in South-Asian patients. Interestingly, changes in microvascular resistance appeared to be similar for both periventricular and deep white matter leukoaraiosis in spite of potential differences in etiopathogenesis.
Source: Neurology India - May 3, 2022 Category: Neurology Authors: Dhing H Kumar Saraf U Umesh Maniangatt C Sinchu Kumar Savith Sankara P Sarma Sukumaran Sajith Source Type: research
Acute Cerebral Microinfarcts in Acute Ischemic Stroke: Imaging and Clinical Significance
Conclusions: We have shown A-CMIs occur in cortical and subcortical regions in nearly half of AIS patients, where microembolism and CSVD are, respectively, the key presumed etiological mechanism.Cerebrovasc Dis
Source: Cerebrovascular Diseases - April 29, 2022 Category: Neurology Source Type: research
Post-Stroke Administration of L-4F Promotes Neurovascular and White Matter Remodeling in Type-2 Diabetic Stroke Mice
Patients with type 2 diabetes mellitus (T2DM) exhibit a distinct and high risk of ischemic stroke with worse post-stroke neurovascular and white matter (WM) prognosis than the non-diabetic population. In the central nervous system, the ATP-binding cassette transporter member A 1 (ABCA1), a reverse cholesterol transporter that efflux cellular cholesterol, plays an important role in high-density lipoprotein (HDL) biogenesis and in maintaining neurovascular stability and WM integrity. Our previous study shows that L-4F, an economical apolipoprotein A member I (ApoA-I) mimetic peptide, has neuroprotective effects via alleviati...
Source: Frontiers in Neurology - April 28, 2022 Category: Neurology Source Type: research
Pregnancy and stroke risk in women
Neurobiol Dis. 2022 Apr 24:105735. doi: 10.1016/j.nbd.2022.105735. Online ahead of print.ABSTRACTStroke associated with pregnancy and post-partum occurs in about 30 per 100,000 deliveries, and includes subtypes of ischemic and hemorrhagic stroke as well as cerebral venous sinus thrombosis (CVST). There are a wide variety of underlying causes and risk factors, some that are common to both pregnant and non-pregnant women, and others that are unique to pregnancy. Although some of the strokes that occur may be a direct result of the pregnancy itself, such as hypertensive disorders of pregnancy, others could be anticipated or p...
Source: Neurobiology of Disease - April 27, 2022 Category: Neurology Authors: Constance Katsafanas Cheryl Bushnell Source Type: research
Current Trends in the Animal Models for Screening of Nootropic Agents
CONCLUSION: Since a variety of etiologies can affect the cognitive processes, hence a nootropic agent may be screened in a variety of disease models. The most widely used and appropriate method to assess cognition would be by combining the behavioral and biochemical assays so that a more comprehensive profile about the nootropic effects of a drug can be elicited.PMID:35469584 | DOI:10.2174/2772432817666220425121323
Source: Epilepsy Curr - April 26, 2022 Category: Neurology Authors: Shubhima Grover Seema Jain Source Type: research
