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Specialty: Laboratory Medicine

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Total 458 results found since Jan 2013.

Plasma Translocator Protein Levels and Outcomes of Acute Ischemic Stroke: A Pilot Study.
In this study, we measured the level of TSPO in acute ischemic stroke patients and determined its association with the degree of stroke severity and its ability to predict stroke functional outcomes. In total, 38 patients with moderate to severe acute ischemic stroke were enrolled. Demographic information, cerebral risk factors, and stroke severity were examined at the baseline. The National Institutes of Health Stroke Scale, modified Rankin Scale, and Barthal Index were assessed at discharge as measures of poor functional outcomes and severe disability. The baseline fasting plasma TSPO level was assessed within 24 h aft...
Source: Disease Markers - July 25, 2018 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

The Association between Platelet Distribution Width and Stroke in Atrial Fibrillation Patients.
CONCLUSIONS: PDW was an important risk factor for stroke in AF patients, suggesting it has the potential to be a new biomarker for predicting stroke. PMID: 30814090 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - December 31, 2018 Category: Laboratory Medicine Authors: Lyu QS, Liu B, Huang C, Huang YQ Tags: Ann Clin Lab Sci Source Type: research

Clinical Utility of Serum Holotranscobalamin Measurements in Patients with First-Ever Ischemic Stroke
CONCLUSIONS: Measurements of serum holoTC levels combined with total B12 and homocysteine levels may provide valuable information for predicting ischemic stroke and its severity and short-term outcomes of ischemic stroke patients.PMID:34545295 | PMC:PMC8449731 | DOI:10.1155/2021/9914298
Source: Disease Markers - September 21, 2021 Category: Laboratory Medicine Authors: Oh Joo Kweon Yong Kwan Lim Mi-Kyung Lee Hye Ryoun Kim Source Type: research

Significant Association of Methylenetetrahydrofolate dehydrogenase 1 Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.
CONCLUSIONS: Our findings suggest a significant association between hypomethylation of the MTHFD1 promoter and stroke in Chinese hypertensive populations. PMID: 30814086 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - December 31, 2018 Category: Laboratory Medicine Authors: Wang C, Xu G, Wen Q, Peng X, Chen H, Zhang J, Xu S, Zhang C, Zhang M, Ma J, Hui Z, Du J, Wu G, Ma M Tags: Ann Clin Lab Sci Source Type: research

Parathyroid Hormone Levels in the Prediction of Ischemic Stroke Risk.
Conclusion. PTH and 25(OH)D levels together can make important contributions to determination of stroke risk, and further investigations are needed to understand this relationship more fully. PMID: 28115793 [PubMed - in process]
Source: Disease Markers - January 25, 2017 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Serum 25-hydroxyvitamin D deficiency predicts long-term poor prognosis among ischemic stroke patients without hyperglycaemia
Conclusion Serum 25(OH)D deficiency may be merely an independent risk factor of 1-year poor prognosis in ischemic stroke patients without hyperglycemia. Future studies about improving long-term prognosis of ischemic stroke by vitamin D supplementation could be first applied to these patients.
Source: Clinica Chimica Acta - May 22, 2017 Category: Laboratory Medicine Source Type: research

Elevated circulating homocysteine and high-sensitivity C-reactive protein jointly predicts post-stroke depression among Chinese patients with acute ischemic stroke
Conclusions Coexistence of both higher HCY and higher hs-CRP in the acute phase of ischemic stroke were associated with subsequent PSD, independently of established conventional risk factors.
Source: Clinica Chimica Acta - February 4, 2018 Category: Laboratory Medicine Source Type: research

Liquid biopsy markers for stroke diagnosis.
Authors: Wijerathne H, Witek MA, Baird AE, Soper SA Abstract INTRODUCTION: There is a short time window (4.5 h) for the effective treatment of acute ischemic stroke (AIS), which uses recombinant tissue plasminogen activator (rt-PA). Unfortunately, this short therapeutic timeframe is a contributing factor to the relatively small number of patients (~7%) that receive rt-PA. While neuroimaging is the major diagnostic for AIS, more timely decisions could be made using a molecular diagnostic. AREAS COVERED: In this review, we survey neuroimaging techniques used to diagnose stroke and their limitations. We also highl...
Source: Expert Review of Molecular Diagnostics - June 7, 2020 Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research

Tumor Necrosis Factor- < em > α < /em > : The Next Marker of Stroke
Dis Markers. 2022 Feb 27;2022:2395269. doi: 10.1155/2022/2395269. eCollection 2022.ABSTRACTAlthough there is no shortage of research on the markers for stroke, to our knowledge, there are no clear markers that can meet the needs of clinical prediction and treatment. The inflammatory cascade is a critical process that persists and functions throughout the stroke process, ultimately worsening stroke outcomes and increasing mortality. Numerous inflammatory factors, including tumor necrosis factor (TNF), are involved in this process. These inflammatory factors play a dual role during stroke, and their mechanisms are complex. A...
Source: Disease Markers - March 10, 2022 Category: Laboratory Medicine Authors: Yimeng Xue Xianwei Zeng Wen-Jun Tu Jizong Zhao Source Type: research