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Specialty: Laboratory Medicine

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Total 458 results found since Jan 2013.

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Poststroke Depression: A Systematic Review and Meta-Analysis
CONCLUSION: These findings indicated that NLR and PLR could be considered inexpensive biomarkers for the prediction of PSD.PMID:35978885 | PMC:PMC9377924 | DOI:10.1155/2022/5911408
Source: Disease Markers - August 18, 2022 Category: Laboratory Medicine Authors: Shirin Sarejloo Erfan Abadifard Zhian Jamal Othman Fatemeh Zafarani Monireh Khanzadeh Saeed Sadigh-Eteghad Fereshteh Farajdokht Asghar Mohammadpoorasl Shokoufeh Khanzadeh Source Type: research

Influence of Evidence-Based Nursing on Psychological Status, Neurological Function, and Life Quality of Patients with Acute Poststroke Depression
CONCLUSIONS: EBN can better improve the PSY of patients with acute PSD, restore their neurological function, and effectively improve their QoL.PMID:36157215 | PMC:PMC9507762 | DOI:10.1155/2022/7099908
Source: Disease Markers - September 26, 2022 Category: Laboratory Medicine Authors: Yan Song Fei Wang Yakun Yang Xing Liu Chenghong Zhu Source Type: research

Anticoagulation Strategies for the Management of Postoperative Atrial Fibrillation
Patients undergoing thoracic and cardiac procedures are at the highest risk for postoperative atrial fibrillation (POAF). POAF is associated with poor short-term and long-term outcomes, including high rates of early and late stroke, and late mortality. Patients with POAF that persists for longer than 48 hours should be anticoagulated on warfarin. Three new oral anticoagulants are available for the treatment of nonvalvular atrial fibrillation and have been found to be as efficacious or superior to warfarin in the prevention of stroke in high-risk patients, with similar to lower rates of major bleeding, and lower rates of i...
Source: Clinics in Laboratory Medicine - July 21, 2014 Category: Laboratory Medicine Authors: Eric Anderson, Cornelius Dyke, Jerrold H. Levy Source Type: research

Interferon-γ in foam cell formation and progression of atherosclerosis
Publication date: 24 February 2015 Source:Clinica Chimica Acta, Volume 441 Author(s): Xiao-Hua Yu , Jian Zhang , Xi-Long Zheng , Yun-Hua Yang , Chao-Ke Tang Interferon-γ (IFN-γ), the sole member in type II IFN predominantly secreted by macrophages and T cells, is a critical regulator of immune function and provides a robust first line of defense against invading pathogens. Binding of IFN-γ to its receptor complex can activate a variety of downstream signaling pathways, particularly the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), to induce gene transcription within the target cells. This...
Source: Clinica Chimica Acta - January 11, 2015 Category: Laboratory Medicine Source Type: research

Therapeutics targeting the inflammasome after central nervous system injury.
Abstract Innate immunity is part of the early response of the body to deal with tissue damage and infections. Because of the early nature of the innate immune inflammatory response, this inflammatory reaction represents an attractive option as a therapeutic target. The inflammasome is a component of the innate immune response involved in the activation of caspase 1 and the processing of pro-interleukin 1β. In this article, we discuss the therapeutic potential of the inflammasome after central nervous system (CNS) injury and stroke, as well as the basic knowledge we have gained so far regarding inflammasome activa...
Source: Translational Research : the journal of laboratory and clinical medicine - May 12, 2015 Category: Laboratory Medicine Authors: de Rivero Vaccari JP, Dietrich WD, Keane RW Tags: Transl Res Source Type: research

Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping
ConclusionWe have successfully developed and validated a pyrosequencing assay that is fast and can yield high‐quality pyrograms for DNA methylation analysis and is therefore applicable to high throughput study. Using this newly developed pyrosequencing assay, the MTHFR DNA methylation profiles of 110 Kelantanese Malays were successfully determined. It also validated our computational epigenetic research on MTHFR.
Source: Journal of Clinical Laboratory Analysis - May 1, 2015 Category: Laboratory Medicine Authors: Loo Keat Wei, Heidi Sutherland, Anthony Au, Emily Camilleri, Larisa M Haupt, Siew Hua Gan, Lyn R Griffiths Tags: Research Article Source Type: research

Effect of PPAR- β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury. Transl Res. 2016 Oct 18;: Authors: Chehaibi K, le Maire L, Bradoni S, Escola JC, Blanco-Vaca F, Slimane MN Abstract The systemic response to ischemic stroke is associated with the hepatic acute phase response (APR) that modulates leukocytes recruitment to the injured brain. The inappropriate recruitment of leukocytes to the brain parenchyma can result in blood-brain barrier (BBB) breakdown. Emerging data suggest that peroxisome proliferator-activated receptor beta/delt...
Source: Translational Research : the journal of laboratory and clinical medicine - October 17, 2016 Category: Laboratory Medicine Authors: Chehaibi K, le Maire L, Bradoni S, Escola JC, Blanco-Vaca F, Slimane MN Tags: Transl Res Source Type: research

Significant elevation of serum caspase-3 levels in patients with intracerebral hemorrhage
Conclusion Serum caspase-3 concentrations are increased in ICH patients as well as correlate with clinical severity and prognosis.
Source: Clinica Chimica Acta - May 19, 2017 Category: Laboratory Medicine Source Type: research

Macrophage migration inhibitory factor levels in serum from patients with acute intracerebral hemorrhage: Potential contribution to prognosis
Conclusions MIF in serum might be a potential biomarker for reflecting inflammation, severity and prognosis of ICH patients.
Source: Clinica Chimica Acta - July 20, 2017 Category: Laboratory Medicine Source Type: research

Association of GPIa and COX ‐2 gene polymorphism with aspirin resistance
ConclusionGPIa gene polymorphism at 807C>T locus was associated with AR in Chinese Han females, and the expression of allele T increased the incidence of AR. The gene polymorphism of COX‐2 gene at ‐765G>C locus was not significantly correlated with AR.
Source: Journal of Clinical Laboratory Analysis - July 1, 2017 Category: Laboratory Medicine Authors: Hui Wang, Xiaoxin Sun, Wanli Dong, Xiuying Cai, Yun Zhou, Youtao Zhang, Weijian Jiang, Qi Fang Tags: RESEARCH ARTICLE Source Type: research

Homocysteine in non-valvular atrial fibrillation: Role and clinical implications
Publication date: December 2017 Source:Clinica Chimica Acta, Volume 475 Author(s): Yan Yao, Mei-sheng Shang, Jian-zeng Dong, Chang-sheng Ma Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a series of adverse complications that cause so-called AF socioeconomic burden. Apart from the classical risk factors, it seems to be novel factors that increase the risk of AF and AF-related stroke. Recently, more and more evidence has well documented the close relationships between homocysteine (Hcy) and AF. As a well-known marker for pro-oxidation and pro-inflammation, Hcy plays an important role in ...
Source: Clinica Chimica Acta - November 9, 2017 Category: Laboratory Medicine Source Type: research

Biomarkers of cerebral microembolic signals
This study aims to review recent biomarker candidates for MES or microembolism. Current research indicates that the following are independent markers for positive MES: high level of serum soluble P-selectin, chemokine (C-X-C motif) ligand 16 (CXCL16) and fibrinogen, high neutrophil count, reduced ratio of CD4+CD25high regulatory T cells (Tregs) and the C allele of tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) rs3102735. However, a more integrated profile of biomarkers for MES is needed to improve the stratification of patients with carotid stenosis and enhance the effectiveness of therapeutic interventi...
Source: Clinica Chimica Acta - November 9, 2017 Category: Laboratory Medicine Source Type: research

Aspirin Resistance: Risk Factors and Prognostic Significance in Patients with Cerebral Small Vessel Disease.
CONCLUSIONS: The prevalence of AR was high and similar among the patients with LS, VaD, and VaP due to CSVD. Higher 24-h MAP and TG were independently related to the risk of AR. AR was associated with risk of radiological progression and lacunar strokes over 24 months of observation. PMID: 29530996 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - January 1, 2018 Category: Laboratory Medicine Authors: Staszewski J, Piusińska-Macoch R, Skrobowska E, Brodacki B, Macek K, Stępień A Tags: Ann Clin Lab Sci Source Type: research