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Specialty: Laboratory Medicine

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Total 458 results found since Jan 2013.

LncRNA < em > PCBP1-AS1 < /em > Induces Cerebral Ischemia/Reperfusion Injury via the < em > miR-506-3p/CCL2 < /em > Axis
CONCLUSION: LncRNA PCBP1-AS1 sequesters miR-506-3p to upregulate CCL2 expression, thereby aggravating I/R injury, suggesting its potential for RNA-targeted treatment of cerebral ischemic stroke.PMID:37437927
Source: Annals of Clinical and Laboratory Science - July 12, 2023 Category: Laboratory Medicine Authors: Zhili He Ling Chen Wei Zhang Source Type: research

A place for ultrastructural analysis of platelets in cerebral ischemic research
ABSTRACT It is well known that estrogen is neuroprotective through various mechanisms which suggest that sex hormone levels, thrombotic mechanisms, and inflammatory processes are strongly interconnected in predicting the outcome and consequences of cerebral ischemia. Because platelet ultrastructure is altered in conditions like thrombosis and associated with stroke, the question arises whether ultrastructural analyses of platelet morphology may provide further insight into the role of estrogen during ischemic insult. In the current study, a hyperglycemic modification to the two‐vessel occlusion model for inducing experim...
Source: Microscopy Research and Technique - May 16, 2013 Category: Laboratory Medicine Authors: Wendy Jeannette Spuy, Etheresia Pretorius Tags: Research Article Source Type: research

Biomarkers for Cholesterol Absorption and Synthesis in Hyperlipidemic Patients: Role for Therapeutic Selection
Increased total serum cholesterol and low-density lipoprotein cholesterol concentrations are associated with atherosclerosis and risk for myocardial infarction and stroke. Those who have high cholesterol with other factors that predispose them to cardiovascular disease should be treated with cholesterol-lowering medications. The pathophysiology of hyperlipidemia is important in the proper selection of drug therapy. Patients who have increased cholesterol synthesis should be medicated with drugs that reduce in vivo cholesterol production, whereas those who have increased dietary absorption of cholesterol should be treated w...
Source: Clinics in Laboratory Medicine - February 7, 2014 Category: Laboratory Medicine Authors: Alan H.B. Wu Source Type: research

Evaluation of the Relationship Between Ischemia‐Modified Albumin Levels and Thyroid Hormone Levels
ConclusionWe suggest that albumin adjusted IMA levels are significantly lower in hypothyroid group than hyperthyroid and euthyroid groups.
Source: Journal of Clinical Laboratory Analysis - May 1, 2014 Category: Laboratory Medicine Authors: Mufide Oncel, Aysel Kıyıcı, Serife Onen Tags: Original Article Source Type: research

Stroke and inherited thrombophilia in a Tunisian girl with sickle cell anemia
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - December 21, 2014 Category: Laboratory Medicine Source Type: research