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Total 458 results found since Jan 2013.
Routine hematological parameters are associated with short ‐ and long‐term prognosis of patients with ischemic stroke
ConclusionRed blood cell distribution width, NLR and eosinophil are independent prognostic factors for IS.
Source: Journal of Clinical Laboratory Analysis - May 22, 2017 Category: Laboratory Medicine Authors: Luo Fan, Li Gui, Er ‐Qing Chai, Chao‐Jun Wei Tags: RESEARCH ARTICLE Source Type: research
Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population.
In this study, the analysis of a possible association between EDN1 rs5370 and EDNRA rs5335 gene polymorphisms and the risk of large artery stroke (LAS) in a Ukrainian population was conducted. 200 LAS patients and 200 unrelated controls were enrolled in a case-control study. The polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP) was used for SNP genotyping. Our results revealed that EDN1 rs5370 polymorphism was associated with LAS development both before and after adjustment for atherosclerosis risk factors (sex, age, body mass index, arterial hypertension, type 2 diabetes mellitus, and sm...
Source: Disease Markers - June 4, 2018 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Severity of Vitamin D Deficiency Predicts Mortality in Ischemic Stroke Patients.
Conclusions: Severe VD deficiency is an emerging, strong negative predictor for survival after IS, independent of age and functional status. VD supplementation in IS survivals may be considered due to high prevalence of its deficiency. However, it is uncertain whether it will improve their survival.
PMID: 31191749 [PubMed - in process]
Source: Disease Markers - June 15, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Association between MicroRNA-4669 Polymorphism and Ischemic Stroke in a Korean Population.
In this study, we investigated the associations between SNPs in miRNAs and IS including rs2910164, rs11614913, and rs3746444 in a Korean population. For a pilot study, we selected 19 SNPs in pre-miRNA region (including mature miRNA region) and genotyped in 140 IS patients and 240 control subjects using the Fluidigm Dynamic Array. Our pilot study showed a weak association of rs79402775 in miRNA-933 (p = 0.044) and a relatively strong association of rs35196866 in miRNA-4669 (p = 0.016) with IS. From the pilot study, we selected rs79402775, rs35196866, and rs7202008 (miRNA-2117; p = 0.055) as candidate miRNA SNPs on IS and fu...
Source: Disease Markers - November 30, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Genetic Polymorphisms Associated with Thrombotic Disease Comparison of Two Territories: Myocardial Infarction and Ischemic Stroke.
Conclusions: The Thr325Ile polymorphism, but no Ala147Thr polymorphism, represents an independent risk factor for STEMI in the young Mexican population.
PMID: 31781299 [PubMed - in process]
Source: Disease Markers - November 30, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Recanalization Treatment of Acute Ischemic Stroke Caused by Large-Artery Occlusion in the Elderly: A Comparative Analysis of "the Elderly" and "the Very Elderly"
CONCLUSION: Recanalization treatment of LAO is more effective in elderly patients compared with very elderly patients, while the safety of recanalization treatment is comparable between these two groups.PMID:34659589 | PMC:PMC8514933 | DOI:10.1155/2021/3579074
Source: Disease Markers - October 18, 2021 Category: Laboratory Medicine Authors: Qi Wang Yi-Qun Zhang Han-Cheng Qiu Yin-Dan Yao Ao-Fei Liu Chen Li Wei-Jian Jiang Source Type: research
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke
Expert Rev Mol Diagn. 2022 Mar 2. doi: 10.1080/14737159.2022.2049246. Online ahead of print.ABSTRACTINTRODUCTION: N6-Methyladenosine (m6A), the most common and reversible mRNA modification, has attracted considerable attention recently, and accumulating evidence indicates it has an important role in the progression of ischemic stroke (IS).AREAS COVERED: We first reviewed m6A methylation modification enzymes, including m6A methyltransferases (METTL3, METTL14, and WTAP), demethylases (FTO and ALKBH5), m6A-binding proteins (YTH domain containing 1/2 [YTHDC1/2], YTHDF1/2/3, and insulin like growth factor 2 mRNA binding protein...
Source: Expert Review of Molecular Diagnostics - March 3, 2022 Category: Laboratory Medicine Authors: Hongtao Chang Jun Yang Qianwen Wang Jingjing Zhao Ruixia Zhu Source Type: research
Construction of a Joint Prediction Model for the Occurrence of Ischemic Stroke and Acute Myocardial Infarction Based on Bioinformatic Analysis
Dis Markers. 2022 Apr 4;2022:5967131. doi: 10.1155/2022/5967131. eCollection 2022.ABSTRACTIschemic stroke (IS) has imposed significant threat to both middle-aged and elderly people worldwide. Acute myocardial infarction (AMI) is a rare but serious complication following IS, which can further increase patient disability and mortality rates. With the development of intravenous thrombolysis and endovascular treatment, the prognosis of IS has been greatly improved. However, the pathogenesis of IS complicated with AMI is still unclear. To fill this gap, this work uses bioinformatic analysis, where IS and AMI datasets were combi...
Source: Disease Markers - April 14, 2022 Category: Laboratory Medicine Authors: Zhaolei Ma Lan Chu Chun-Feng Liu Wupeng Liu Jing Wei Source Type: research
miR-9a-5p Protects Ischemic Stroke by Regulating Oxidative Stress and Mitochondrial Autophagy
CONCLUSION: miR-9a-5p protects against ischemic stroke by inhibiting OGD/R-induced mitochondrial autophagy and alleviating cellular oxidative stress injury.PMID:36845011 | PMC:PMC9957637 | DOI:10.1155/2023/5146305
Source: Disease Markers - February 27, 2023 Category: Laboratory Medicine Authors: Chunli Ma Qing Gao Li Zhang Geng Wu Chao Li Jun Chen Yuxuan Fu Lei Yang Source Type: research
Novel POLG mutation in a patient with sensory ataxia, neuropathy, ophthalmoparesis and stroke
Conclusions The novel mutation contributes to the expanding spectrum of disease-causing mutations. A definitive diagnosis can benefit our patient and also the relatives by avoiding sodium valproate induced liver toxicity in POLG patients and also the heterozygotes.
Source: Clinica Chimica Acta - July 28, 2015 Category: Laboratory Medicine Source Type: research
The ACE2 G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke
ConclusionThe ACE2 G8790A polymorphism in T2DM patients was correlated with CS, and the A allele might be a risk factor of T2DM combined with CS.
Source: Journal of Clinical Laboratory Analysis - June 30, 2016 Category: Laboratory Medicine Authors: Yan ‐Hui Wu, Jia‐Ying Li, Chi Wang, Li‐Mei Zhang, Hong Qiao Tags: Research Article Source Type: research
