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Specialty: Urology & Nephrology

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Total 1393 results found since Jan 2013.

Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes
CONCLUSION: Quality of life was impaired in patients starting haemodialysis. A higher C-reactive protein level level was a consistent independent predictor of the majority of worse quality of life. Transferrin saturation ≤ 20% was associated with worse physical component score of quality of life. Baseline quality of life was predictive of all-cause mortality and the primary outcome measure.EUDRACT REGISTRATION NUMBER: 2013-002267-25.PMID:36995528 | PMC:PMC10061401 | DOI:10.1007/s40620-023-01571-6
Source: Journal of Nephrology - March 30, 2023 Category: Urology & Nephrology Authors: Sunil Bhandari Patrick Parfrey Claire White Stefan D Anker Kenneth Farrington Ian Ford Philip A Kalra John J V McMurray Michele Robertson Charles R V Tomson David C Wheeler Iain C Macdougall PIVOTAL Investigators, Committees Source Type: research

journal club
Takahashi et  al., on behalf of the American Heart Association Council on Cardiovascular Radiology and Intervention; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Stroke Council. (Circulation. 2022;146:e558–e568.)
Source: Kidney International - March 20, 2023 Category: Urology & Nephrology Tags: Journal Club Source Type: research

Outcomes with Finerenone in Participants with Stage 4 CKD and Type 2 Diabetes: A FIDELITY Subgroup Analysis
Conclusions The cardiovascular benefits and safety profile of finerenone in participants with stage 4 CKD were consistent with the overall FIDELITY population; this was also the case for albuminuria and the rate of eGFR decline. The effects on the composite kidney outcome were not consistent over time.PMID:36927680 | DOI:10.2215/CJN.0000000000000149
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 17, 2023 Category: Urology & Nephrology Authors: Pantelis Sarafidis Rajiv Agarwal Bertram Pitt Christoph Wanner Gerasimos Filippatos John Boletis Katherine R Tuttle Luis M Ruilope Peter Rossing Robert Toto Stefan D Anker Zhi-Hong Liu Amer Joseph Christiane Ahlers Meike Brinker Robert Lawatscheck George Source Type: research

Causal association of cardiovascular disease with erectile dysfunction: A two ‐sample bidirectional Mendelian randomization analysis
ConclusionsOur results, based on MR, indicated that genetic susceptibility to IS, HF, and CHD was causally associated with ED. These findings can inform prevention and intervention strategies for ED in IS, HF, and CHD patients.This article is protected by copyright. All rights reserved
Source: Andrology - March 9, 2023 Category: Urology & Nephrology Authors: Miaoyong Ye, Jiaxing Chen, Jianxiong Ma, Junwei Wang, Cunming Zhang, Baijun Chen, Zhongbiao Wu, Fan Zhao, Lan Ma Tags: ORIGINAL ARTICLE Source Type: research

Incidence of Statin-Associated Adverse Events in Kidney Transplant Recipients
CONCLUSIONS: Statins appear to be generally well-tolerated in kidney transplant recipients. However, statin use might be associated with slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.PMID:36800538 | DOI:10.2215/CJN.0000000000000124
Source: Clinical Journal of the American Society of Nephrology : CJASN - February 17, 2023 Category: Urology & Nephrology Authors: Sunjae Bae JiYoon B Ahn Kmd Corey Joseph Ryan Whisler Mark A Schnitzler Krista L Lentine Bernard S Kadosh Dorry L Segev Mara A McAdams-DeMarco Source Type: research

The role of gut-dependent molecule trimethylamine N-oxide as a novel target for the treatment of chronic kidney disease
AbstractTrimethylamine N-oxide (TMAO) is an intestinal uremic toxin molecule mainly excreted by the kidney. Therefore, the plasma TMAO concentration is significantly increased in chronic kidney disease (CKD) patients, and plasma TMAO can be cleared by dialysis. Furthermore, TMAO damage the kidney mainly through three mechanisms: oxidative stress, inflammation and endoplasmic reticulum stress. Clinical experiments have indicated that higher TMAO levels are strongly related to the elevated incidence and mortality of cardiovascular (CV) events in CKD patients. Moreover, experimental data have shown that high levels of TMAO di...
Source: International Urology and Nephrology - February 16, 2023 Category: Urology & Nephrology Source Type: research