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Bilateral large vessel occlusion causing massive ischemic stroke in a covid-19 patient
The case of a 70-year-old male presenting an ischemic stroke related to COVID-19 infection is described. He was initially admitted to the hospital with respiratory insufficiency syndrome secondary to pneumonia caused by SARS Co2. In the next days, he developed rapid neurological deterioration characterized by drowsiness which progressed to deep coma. D-dimer was elevated. Brain CT scan showed bilateral massive ischemic stroke located in the anterior circulation, CT angiogram showed occlusion in the left internal carotid artery and the right middle cerebral artery.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2021 Category: Neurology Authors: Luis A. Robles Tags: Case Report Source Type: research

Stroke Care during the COVID-19 Pandemic: International Expert Panel Review
This study, prepared by a large international panel of stroke experts, assesses the rapidly growing research and personal experience with COVID-19 stroke and offers recommendations for stroke management in this challenging new setting: modifications needed for prehospital emergency rescue and hyperacute care; inpatient intensive or stroke units; posthospitalization rehabilitation; follow-up including at-risk family and community; and multispecialty departmental developments in the allied professions.Summary: The severe acute respiratory syndrome coronavirus 2 uses spike proteins binding to tissue angiotensin-converting enz...
Source: Cerebrovascular Diseases - March 23, 2021 Category: Neurology Source Type: research

COVID-19 Infection and Recurrent Stroke in Young Patients With Protein S Deficiency: A Case Report
Conclusions: SARS-CoV-2 infection potentializes the prothrombotic effect and vascular inflammation by accentuating protein S deficit. The place of steroids seems justifiable in the presence of symptoms of vasculitis in brain imaging.
Source: The Neurologist - November 1, 2021 Category: Neurology Tags: Case Report/Case Series Source Type: research

Regional Mechanical Thrombectomy Imaging Protocol in Patients Presenting with Acute Ischemic Stroke during the COVID-19 Pandemic INTERVENTIONAL
CONCLUSIONS: Chest CT provides a pragmatic, rapid additional tool for COVID-19 risk stratification among patients referred for mechanical thrombectomy. Its inclusion in a standardized regional stroke imaging protocol has enabled efficient use of hospital resources with minimal compromise or delay to the overall patient treatment schedule.
Source: American Journal of Neuroradiology - October 5, 2020 Category: Radiology Authors: Dhillon, P. S., Pointon, K., Lenthall, R., Nair, S., Subramanian, G., McConachie, N., Izzath, W. Tags: INTERVENTIONAL Source Type: research

Carotid free-floating thrombus in COVID-19: a cerebrovascular disorder of cytokine storm-related immunothrombosis
CONCLUSIONS: COVID-19-induced immunothrombosis possibly played a significant pathogenic role in CFFT.PMID:36807242 | DOI:10.1007/s10072-023-06682-3
Source: Atherosclerosis - February 22, 2023 Category: Cardiology Authors: Umberto Pensato Stefano Forlivesi Mauro Gentile Michele Romoli Lorenzo Muccioli Francesca Ambrosi Maria Pia Foschini Carmine Gallo Maria Sandra Ballestrazzi Paolo Teutonico Gianluca Faggioli Mauro Gargiulo Simone Galluzzo Francesco Taglialatela Luigi Simo Source Type: research

Incidental Finding of Arteria Lusoria in COVID-19 Patient with Aortic Thrombus Complicated by Recurrent Limb Ischemia
We report the case of a 64-year-old woman with recent severe acute respiratory syndrome coronavirus 2 pneumonia who was admitted to the hospital due to a giant floating thrombus in the ascending aorta with multiple ischemic events. Aortic computed tomography angiogram revealed an aberrant right subclavian artery associated with bicarotid trunk that might have protected carotid arteries from embol migration. Thrombosis is a rare clinical presentation in coronavirus disease 2019 infection but with serious complications that must be kept in mind to detect and avoid morbidities like ischemic stroke. [...] Thieme Medical Publis...
Source: International Journal of Angiology - June 12, 2023 Category: Cardiology Authors: Khedija, Soumer Nadia, Azabou Houcine, Horchani Mouna, Bousnina Amine, Jemel Tags: Case Report Source Type: research

The potential role of microvascular pathology in the neurological manifestations of coronavirus infection
We present the hypothesis that pre-existing vascular damage (due to aging, cardiovascular disease, diabetes, hypertension or other conditions) facilitates infiltration of the virus into the central nervous system (CNS), increasing neuro-inflammation and the likelihood o f neurological symptoms. We also discuss the role of a neuroinflammatory cytokine profile in both blood–brain barrier dysfunction and macrovascular disease (e.g. ischemic stroke and thromboembolism). Future studies are needed to better understand the involvement of the microvasculature in coronavi rus neuropathology, and to test the diagnostic potential o...
Source: Fluids and Barriers of the CNS - September 9, 2020 Category: Neuroscience Source Type: research

Focal cerebral arteriopathy in a young adult following SARS-CoV2 reinfection
Ten days after SARS-Cov2 reinfection with mild gastrointestinal symptoms and headache that occurred 2 months after an initial infection, a previously healthy 37-year-old woman developed fluctuating facial and upper limb paresthesia and weakness. Diffusion-weighted magnetic resonance imaging revealed ischemic lesions in the right parietal region of different stages within the same vascular territory. A cerebral angiography demonstrated an isolated focal arteriopathy with no other arterial involvement.
Source: Journal of Stroke and Cerebrovascular Diseases - June 12, 2021 Category: Neurology Authors: Carla Zanferrari, Simona Fanucchi, Maria Teresa Sollazzo, Michela Ranieri, Daniel Volterra, Luca Valvassori Source Type: research

Ischaemic stroke due to basilar artery occlusion in a puerperal patient with SARS-CoV-2 infection
CONCLUSION: Severe SARS-CoV-2 disease results in a prothrombotic state that correlates with the prognosis of the disease. The last trimester of pregnancy and the puerperium are known prothrombotic risk factors. Recommendations for anticoagulation management in pregnant patients with COVID-19 are based on limited evidence. This is the first case to be published in Spain involving cerebral arterial thrombosis in a pregnant patient with SARS-CoV-2 infection.PMID:35866535 | DOI:10.33588/rn.7504.2021373
Source: Revista de Neurologia - July 22, 2022 Category: Neurology Authors: M G ómez-Martí V Bosch ín F Puchades A Cerd án A Cunquero F Sanz J J Tamarit Source Type: research

SARS-CoV-2 infection and SLE: endothelial dysfunction, atherosclerosis, and thrombosis
We present systemic lupus erythematosus (SLE) as a model rheumatic disease with endothelial dysfunction and discuss its mechanisms, factors that influence the early onset and rapid progression of atherosclerosis, and the increased risk of thromboembolic events. We focus on established methods to improve endothelium function, including statins, antiplatelet, and antithrombotic therapy. Hypercoagulable and hypofibrinolitic states and a hyperinflammatory response characterize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathogenic mechanisms are typical for an acute phase of Covid-19 post-Co...
Source: Clinical Rheumatology - January 9, 2023 Category: Rheumatology Source Type: research

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