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Total 207 results found since Jan 2013.

Ntox-08. safety of intra-arterial chemotherapy in the treatment of brain tumours
The treatment of brain tumors is greatly limited the delivery impediment caused by the blood-brain barrier and blood-tumor barrier. To circumvent this limitation, different approaches have been studied, including intra-arterial delivery. Because of a significant local increase in plasma-peak concentration, this strategy increases the local area under the curve, and translates into a 3 to 5.5 fold increase in intra-tumoral chemotherapy concentration. However, intra-arterial chemotherapy in the treatment of brain tumors has a notoriously bad name, thanks to prior trials led in past decades showing significant neurotoxicities...
Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Fortin, D., Caux, S., Gahide, G. Tags: NEUROTOXICITY OF THERAPY Source Type: research

Retroperitoneal haematoma in a postoperative ALIF patient taking rivaroxaban for atrial fibrillation
ConclusionThis is the first case of a rivaroxaban-induced retroperitoneal haematoma reported in the literature, secondary to elective spinal surgery. This report adds to the body of evidence on the risk of postoperative bleeding in patients taking NOACs. If patients on NOACs present with abdominal symptoms following anterior approach to the lumbar spine, treating clinicians should have a high index of suspicion for retroperitoneal haematoma.
Source: European Spine Journal - November 1, 2016 Category: Orthopaedics Source Type: research

Transfemoral TAVI procedure in women: Minimally-invasive technique.
We report here the case of a patient treated by means of a "minimalist" approach to TAVI allowing a reduction of the risks inherent in the procedure. This simplified strategy relies on an optimal use of CT scan findings prior to TAVI. The procedure is carried out under local anesthesia and the main access site is sutured percutaneously (Proglides). The radial artery is used as a secondary access site. Contrast medium is diluted and stimulation is administered via the intraventricular guidewire. Direct stenting is performed when deemed feasible on the basis of CT scan results. Simplified procedures such as these contribute ...
Source: Annales de Cardiologie et d'Angeiologie - November 1, 2016 Category: Cardiology Authors: Benamer H, Chevalier B, Roy A, Bouzid MA, Perdrix C, Garot P, Hovasse T, Unterseeh T, Champagne S, Lefèvre T Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Early introduction of direct oral anticoagulants in cardioembolic stroke patients with non-valvular atrial fibrillation
AbstractDirect oral anticoagulants (DOACs) are superior to warfarin in reduction of the intracranial bleeding risk. The aim of the present study was to assess whether early DOAC introduction (1 –3 days after onset) in stroke patients with non-valvular atrial fibrillation (nVAF) may be safe and effective, compared with DOAC introduction after 4–7 days. We conducted a prospective analysis based on data collected from 147 consecutive nVAF patients who started DOAC within 7 days after stro ke onset. In all patients, we performed pre-DOAC CT scan 24–36 h after onset and follow-up CT scan at 7 days after DOAC introduction...
Source: Journal of Thrombosis and Thrombolysis - September 3, 2016 Category: Hematology Source Type: research

Gender differences and bleeding complications after PCI on first and second generation DES.
CONCLUSION: Despite higher risk profile, women treated with DES have similar outcomes as males in 1-year follow-up. However there is, an increased risk of in-hospital bleedings in women. PMID: 27471987 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - July 31, 2016 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Post‐operative serious adverse events in a mixed surgical population – a retrospective register study
ConclusionWe found a risk of one or more events in the composite outcome within 342 days after inclusion of the last patients of 8.3% (7.8–9.0). The results are applicable in estimations of adequate sample sizes in future clinical trials investigating effects of interventions on SAEs.
Source: Acta Anaesthesiologica Scandinavica - July 15, 2016 Category: Anesthesiology Authors: M. S. Hansen, E. E. Petersen, J. B. Dahl, J. Wetterslev Tags: Original Article Source Type: research

Post ‐operative serious adverse events in a mixed surgical population – a retrospective register study
ConclusionWe found a risk of one or more events in the composite outcome within 342 days after inclusion of the last patients of 8.3% (7.8–9.0). The results are applicable in estimations of adequate sample sizes in future clinical trials investigating effects of interventions on SAEs.
Source: Acta Anaesthesiologica Scandinavica - July 13, 2016 Category: Anesthesiology Authors: M. S. Hansen, E. E. Petersen, J. B. Dahl, J. Wetterslev Tags: Original Article Source Type: research

New imaging method may predict risk of post-treatment brain bleeding after stroke
In a study of stroke patients, investigators confirmed through MRI brain scans that there was an association between the extent of disruption to the brain's protective blood-brain barrier and the severity of bleeding following invasive stroke therapy. The results of the National Institutes of Health-funded study were published in Neurology.
Source: ScienceDaily Headlines - June 18, 2016 Category: Science Source Type: news

Cardiovascular highlights from non-cardiology journals
Pre-operative aspirin does not influence CABG outcomes Aspirin is a common therapy for risk reduction among patients with coronary artery disease. However, among patients undergoing coronary artery bypass surgery, the benefits of aspirin on the risk of myocardial infarction and stroke may be outweighed by perioperative bleeding risk. To address this question, the ATACAS trial randomized 2100 patients to either receive 100 mg aspirin daily or matching placebo for 4 days immediately prior to the operation with all patients resuming aspirin within 24 hours of their bypass surgery. The primary outcome was a composite of d...
Source: Heart - June 5, 2016 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

Leukocyte Count and Intracerebral Hemorrhage Expansion Clinical Sciences
Conclusions— Higher admission white blood cell count is associated with lower risk of hematoma expansion. This highlights a potential role of the inflammatory response in modulating the coagulation cascade after acute ICH.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Morotti, A., Phuah, C.-L., Anderson, C. D., Jessel, M. J., Schwab, K., Ayres, A. M., Pezzini, A., Padovani, A., Gurol, M. E., Viswanathan, A., Greenberg, S. M., Goldstein, J. N., Rosand, J. Tags: Intracranial Hemorrhage Clinical Sciences Source Type: research

Study: 'mini strokes should be treated immediately with aspirin'
Conclusion The study supports current recommended practice that people with a TIA or ischaemic stroke caused by a blood clot are treated with aspirin as soon as possible. NHS experts are considering whether to recommend that you take aspirin yourself while waiting for medical help. The reason this isn't recommended at present is that some people will have had a haemorrhagic (bleeding) stroke, and aspirin can make the bleeding worse. For people who've had a full stroke, an urgent brain scan is usually performed to exclude bleeding as a cause and check it's safe to proceed with anti-clotting treatment. The risk of trans...
Source: NHS News Feed - May 19, 2016 Category: Consumer Health News Tags: Neurology Medication Source Type: news

Surgical factors and complications affecting hospital outcome in redo mitral surgery: insights from a multicentre experience ADULT CARDIAC
CONCLUSIONS ReMVS still carries the risk of significant early mortality and major morbidity. Major lesion to cardiovascular structures is the most dreadful iatrogenic complication, and injury of a previous LIMA graft identifies patients at higher risk of operative mortality. Prolonged cross-clamp times, extracellular crystalloid cardioplegia and massive transfusions have profound impact on early outcome, as well as the development of perioperative AMI, eventually requiring IABP and prolonged intubation. The combination of antegrade and retrograde cardioplegia seems to offer a better myocardial protection in these high-risk patients.
Source: European Journal of Cardio-Thoracic Surgery - April 28, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Onorati, F., Perrotti, A., Reichart, D., Mariscalco, G., Della Ratta, E., Santarpino, G., Salsano, A., Rubino, A., Biancari, F., Gatti, G., Beghi, C., De Feo, M., Mignosa, C., Pappalardo, A., Fischlein, T., Chocron, S., Detter, C., Santini, F., Faggian, G Tags: Basic research vascular ADULT CARDIAC Source Type: research

Modeling and design of a cone-beam CT head scanner using task-based imaging performance optimization.
Abstract Detection of acute intracranial hemorrhage (ICH) is important for diagnosis and treatment of traumatic brain injury, stroke, postoperative bleeding, and other head and neck injuries. This paper details the design and development of a cone-beam CT (CBCT) system developed specifically for the detection of low-contrast ICH in a form suitable for application at the point of care. Recognizing such a low-contrast imaging task to be a major challenge in CBCT, the system design began with a rigorous analysis of task-based detectability including critical aspects of system geometry, hardware configuration, and art...
Source: Physics in Medicine and Biology - April 1, 2016 Category: Physics Authors: Xu J, Sisniega A, Zbijewski W, Dang H, Stayman JW, Wang X, Foos DH, Aygun N, Koliatsos VE, Siewerdsen JH Tags: Phys Med Biol Source Type: research