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Condition: Diabetes Type 2
Procedure: Coronary Artery Bypass Graft

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Total 51 results found since Jan 2013.

Long-Term Risk of Stroke in Patients With Type 1 and Type 2 Diabetes Following Coronary Artery Bypass Grafting Cardiovascular Surgery
Conclusions The long-term risk for stroke after coronary artery bypass grafting was increased in patients with type 1 and type 2 diabetes, compared to patients with no diabetes.
Source: JAHA:Journal of the American Heart Association - November 9, 2015 Category: Cardiology Authors: Nystrom, T., Holzmann, M. J., Sartipy, U. Tags: Cardiovascular Surgery Source Type: research

Everolimus Eluting Stents Versus Coronary Artery Bypass Graft Surgery for Patients With Diabetes Mellitus and Multivessel Disease Coronary Artery Disease
Conclusions— In patients with diabetes mellitus and multivessel disease, EES was associated with lower upfront risk of death and stroke when compared with coronary artery bypass graft surgery. However, at long-term, EES was associated with similar risk of death, a higher risk of MI (in those with incomplete revascularization), and repeat revascularization but a lower risk of stroke.
Source: Circulation: Cardiovascular Interventions - July 8, 2015 Category: Cardiology Authors: Bangalore, S., Guo, Y., Samadashvili, Z., Blecker, S., Xu, J., Hannan, E. L. Tags: Type 2 diabetes, Catheter-based coronary interventions: stents, CV surgery: coronary artery disease, Chronic ischemic heart disease Source Type: research

Effect of prompt revascularization on outcomes in diabetic patients with stable ischemic heart disease and previous myocardial infarction in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial
Conclusion: In diabetic patients with SIHD and previous MI, adding prompt revascularization to intensive medical therapy yielded no benefit compared with intensive medical therapy alone. These findings underscore the importance of intensive medical therapy in mitigating further ischemic events.
Source: Coronary Artery Disease - April 27, 2017 Category: Cardiology Tags: Original Research Source Type: research

On-pump versus off-pump coronary artery bypass graft surgery among patients with type 2 diabetes in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial ADULT CARDIAC
CONCLUSIONS Patients with diabetes had greater risk of major cardiovascular events long-term after off-pump CABG than after on-pump CABG.
Source: European Journal of Cardio-Thoracic Surgery - January 13, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Singh, A., Schaff, H. V., Mori Brooks, M., Hlatky, M. A., Wisniewski, S. R., Frye, R. L., Sako, E. Y., on behalf of the BARI 2D Study Group Tags: Electrophysiology - arrhythmias, Molecular biology ADULT CARDIAC Source Type: research

Ischemic Optic Neuropathy in Cardiac Surgery Incidence and Risk Factors in the United States from the National Inpatient Sample 1998 to 2013
Conclusions The incidence of ischemic optic neuropathy in cardiac surgery did not change during the study period. Development of ischemic optic neuropathy after cardiac surgery is associated with carotid artery stenosis, stroke, and degenerative eye conditions.
Source: Anesthesiology - April 18, 2017 Category: Anesthesiology Source Type: research

Coronary artery bypass grafting versus percutaneous coronary intervention in patients with non ‐insulin treated type 2 diabetes mellitus: a meta‐analysis of randomized controlled trials
ConclusionsIn NITDM patients, our study suggests that CABG surgery is associated with reduced risk of mortality and morbidity, though with increased incidence of stroke compared with PCI. The decision if to have PCI or CABG surgery should factor the risk for stroke of the patients when considering CABG over PCI. Adequately‐powered randomized controlled trials are needed to confirm the results of this meta‐analysis.
Source: Diabetes/Metabolism Research and Reviews - September 1, 2017 Category: Endocrinology Authors: Yushu Wang, Meiqin Wen, Junteng Zhou, Yucheng Chen, Qing Zhang Tags: RESEARCH ARTICLE Source Type: research

Coronary artery bypass grafting versus percutaneous coronary intervention in patients with noninsulin treated type 2 diabetes mellitus: A meta ‐analysis of randomized controlled trials
ConclusionsIn NITDM patients, our study suggests that CABG surgery is associated with reduced risk of mortality and morbidity, although with increased incidence of stroke compared with percutaneous coronary intervention. The decision if to have percutaneous coronary intervention or CABG surgery should factor the risk for stroke of the patients when considering CABG over percutaneous coronary intervention. Adequately powered RCTs are needed to confirm the results of this meta‐analysis.
Source: Diabetes/Metabolism Research and Reviews - October 19, 2017 Category: Endocrinology Authors: Yushu Wang, Meiqin Wen, Junteng Zhou, Yucheng Chen, Qing Zhang Tags: RESEARCH ARTICLE Source Type: research

Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial
This study is registered with ClinicalTrials.gov, number NCT00300976. Findings Between June 16, 2006, and March 31, 2009, 2542 eligible patients were randomly assigned to intensive therapy or conventional therapy (1271 in each group) and followed up for a median of 8·5 years (IQR 7·3–9·0). Two patients in the intensive therapy group were found to be ineligible after randomisation and were excluded from the analyses. During the intervention period, mean HbA1c, systolic blood pressure, diastolic blood pressure, and LDL cholesterol concentrations were significantly lower in the intensive therapy group than in the convent...
Source: The Lancet Diabetes and Endocrinology - October 25, 2017 Category: Endocrinology Source Type: research

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial
Publication date: Available online 1 September 2019Source: The LancetAuthor(s): Deepak L Bhatt, Philippe Gabriel Steg, Shamir R Mehta, Lawrence A Leiter, Tabassome Simon, Kim Fox, Claes Held, Marielle Andersson, Anders Himmelmann, Wilhelm Ridderstråle, Jersey Chen, Yang Song, Rafael Diaz, Shinya Goto, Stefan K James, Kausik K Ray, Alexander N Parkhomenko, Mikhail N Kosiborod, Darren K McGuire, Robert A HarringtonSummaryBackgroundPatients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. T...
Source: The Lancet - September 2, 2019 Category: General Medicine Source Type: research

Prognostic implications of DPP‐4 inhibitor vs. sulfonylurea use on top of metformin in a real world setting – results of the 1 year follow‐up of the prospective DiaRegis registry
ConclusionsThe present results confirm prior randomised controlled trial results in patients with type 2 diabetes from real world clinical practice demonstrating that DPP4‐I on top of prior metformin monotherapy result in similar HbA1c reductions within 12 months but a significant reduction in hypoglycaemia compared with sulfonylurea added to metformin. The reduction in vascular events observed has to be verified in larger cohorts.
Source: International Journal of Clinical Practice - August 28, 2013 Category: Internal Medicine Authors: A. K. Gitt, P. Bramlage, C. Binz, M. Krekler, E. Deeg, D. Tschöpe Tags: Original Paper Source Type: research

Surgical revascularization for patients with diabetes: Do all roads lead to Rome?
The BARI 2D trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes Trial)1 randomly allocated patients with type 2 diabetes and stable coronary artery disease (CAD) and evidence of myocardial ischemia to undergo, at the discretion of the treating physician, either early revascularization with a percutaneous intervention (PCI) or coronary artery bypass grafting (CABG) with optimal medical therapy (OMT), or OMT alone. Patients in the OMT group were also randomly assigned to insulin-sensitizing strategy (metformin and thiazolidinedione) or an insulin-providing strategy (insulin or secretagogue.) The 5-year follo...
Source: The Journal of Thoracic and Cardiovascular Surgery - August 28, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Tomas A. Salerno Tags: Editorial commentary Source Type: research

Abstract 263: Incidence of Recurrent Cardiovascular Events and Disease Burden Among High-Risk Patients with Hyperlipidemia Session Title: Poster Session II
Conclusions: CV event-related risk and long-term costs are significantly greater among high-risk patients with shorter time intervals between recurrent CV events. Underutilization of LLTs in these patients highlights the need for improving clinical management and treatment options for these patients.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Punekar, R. S., Fox, K. M., Richhariya, A., Fisher, M. D., Gandra, S. R., Cziraky, M. J., Toth, P. P. Tags: Session Title: Poster Session II Source Type: research

Comparing the Clinical Outcomes Between Insulin-treated and Non-insulin-treated Patients With Type 2 Diabetes Mellitus After Coronary Artery Bypass Surgery: A Systematic Review and Meta-analysis
Abstract: Several studies have shown coronary artery bypass surgery (CABG) to be beneficial in patients with type 2 diabetes mellitus (T2DM) and multivessel coronary artery diseases. Patients with insulin-treated T2DM (ITDM) are usually patients with poor glycemic control and are expected to suffer more complications compared with patients with non-insulin-treated T2DM (NITDM). However, the adverse clinical outcomes in patients with ITDM and NITDM after CABG are still not very clear. Hence, to solve this issue, we aim to compare the short-and long-term adverse clinical outcomes in a larger number of patients with ITDM and ...
Source: Medicine - March 1, 2016 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

PodMed: A Medical News Roundup From Johns Hopkins (with audio)
(MedPage Today) -- This week's topics include reducing suicide, CABG plus medicines for some people, stroke risk following a TIA, and metformin first for type 2 diabetes
Source: MedPage Today Primary Care - April 23, 2016 Category: Primary Care Source Type: news

Medical Treatment and Revascularization Options in Patients With Type 2 Diabetes and Coronary Disease
This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement.MethodsA patient-level pooled analysis was undertaken in 3 federally-funded trials. The primary endpoint was the composite of death, myocardial infarction (MI), or stroke, adjusted for trial and randomization strategy.ResultsAmong 5,034 subjects, 15% had LVEF  
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - August 29, 2016 Category: Radiology Source Type: research