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Response to “Measuring the Optic Nerve Sheath Diameter with Ultrasound in Acute Middle Cerebral Artery Stroke Patients”: For Application to Long-Duration Spaceflight (LDSF)
We thank the authors of the study for their contribution to literature and their insights into the utilisation of optic nerve sheath diameter (ONSD) measurements with regards to therapeutic efficacy of thrombolytic therapy (TT) and identification of complications in populations post-MCA stroke. We would like to introduce the discussion of potential translational benefits of this methodology to the field of long-duration spaceflight (LDSF).
Source: Journal of Stroke and Cerebrovascular Diseases - January 20, 2021 Category: Neurology Authors: Chloe A. Mohanadass, Lauren E. Church Tags: Letter to the Editor Source Type: research

Reply to: Response to “measuring the optic nerve sheath diameter with ultrasound in acute middle cerebral artery stroke patients”: For application to Long-Duration Spaceflight (LDSF)
We thank Mohanadass and Church for their interest in using Optic Nerve Sheath Diameter (ONSD) measurements in Acute Middle Cerebral Artery (MCA) stroke patients to evaluate the effect of thrombolytic therapy and identify high-risk patients.1
Source: Journal of Stroke and Cerebrovascular Diseases - January 23, 2021 Category: Neurology Authors: Seda G üzeldağ, Gökhan Yılmaz Tags: Letter to the Editor Source Type: research

Combining transcranial ultrasound with intelligent communication methods to enhance the remote assessment and management of stroke patients: Framework for a technology demonstrator
With over 150,000 strokes in the United Kingdom every year, and more than 1 million living survivors, stroke is the third most common cause of death and the leading cause of severe physical disability among adults. A major challenge in administering timely treatment is determining whether the stroke is due to vascular blockage (ischaemic) or haemorrhage. For patients with ischaemic stroke, thrombolysis (i.e. pharmacological ‘clot-busting’) can improve outcomes when delivered swiftly after onset, and current National Health Service Quality Improvement Scotland guidelines are for thrombolytic therapy to be provid...
Source: Health Informatics Journal - August 8, 2016 Category: Information Technology Authors: Mort, A., Eadie, L., Regan, L., Macaden, A., Heaney, D., Bouamrane, M.-M., Rushworth, G., Wilson, P. Tags: Articles Source Type: research

Successful Systemic Thrombolysis in an Adolescent With Acute Ischemic Stroke
Conclusions: Despite the lack of evidence regarding the safety and the efficacy of recombinant tissue plasminogen activator in pediatric stroke, this treatment option should be considered, especially in adolescents presenting within 3 hours from symptom onset in centers with consolidated experience in adult thrombolysis.
Source: The Neurologist - September 1, 2015 Category: Neurology Tags: Case Report/Case Series Source Type: research

Cryptogenic Stroke Caused by Pulmonary Arterial Venous Malformation with Massive Right-to-Left Shunt: A Case Report
ConclusionsPAVM is an important risk factor for PE and CS and should not be ignored as a possible etiology in stroke patients without any other risk factors. CTA of the pulmonary artery is the recommended gold standard for diagnosing and locating a PAVM. Thrombolytic therapy within the time window combined with transcatheter device occlusion of arteriovenous malformation and rehabilitation training may benefit the recovery of patients with CS caused by PE resulting from PAVM.
Source: Neurology and Therapy - September 3, 2021 Category: Neurology Source Type: research

In Vitro Evaluation of Focused Ultrasound-Enhanced TNK-Tissue Plasminogen Activator-Mediated Thrombolysis
The low and incomplete recanalization performance of thrombolytic therapy in patients with acute ischemic stroke has created the need to use focused ultrasound (FUS) energy as a way to enhance thrombolysis efficiency (sonothrombolysis). Using an in vitro flow model, the role of various parameters involved in FUS-enhanced tenecteplase (TNK-tPA [tissue plasminogen activator])-mediated thrombolysis was evaluated.
Source: Journal of Stroke and Cerebrovascular Diseases - May 1, 2016 Category: Neurology Authors: Nikolaos Papadopoulos, Christakis Damianou Source Type: research

The Enhancing Effect of Focused Ultrasound on TNK-Tissue Plasminogen Activator-Induced Thrombolysis Using an In Vitro Circulating Flow Model
The limited efficacy of thrombolytic therapy in patients with ischemic stroke has created the need to use focused ultrasound (FUS) energy as a way to enhance thrombolysis efficacy (sonothrombolysis). Using an in vitro circulating flow model, we evaluated the role of physical parameters on tenecteplase (TNK-tPA)-mediated thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2016 Category: Neurology Authors: Nicos Papadopoulos, Christos Yiallouras, Christakis Damianou Source Type: research

Sonothrombolysis.
Authors: Meairs S Abstract Ultrasound (US) applied as an adjunct to thrombolytic therapy improves the recanalization of occluded vessels, and microbubbles can amplify this effect. New data suggests that the combination of US and microbubbles without tissue plasminogen activator may achieve recanalization with a lower risk of hemorrhage. Further possibilities include specific targeting of thrombus with immunobubbles as well as local drug delivery with US-sensitive liposomes. Clinical studies support the use of US for ischemic stroke therapy, and the first trials of enhancing sonothrombolysis with microbubbles have b...
Source: Frontiers of Neurology and Neuroscience - December 2, 2015 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Thrombus-Targeted Theranostic Microbubbles: A New Technology towards Concurrent Rapid Ultrasound Diagnosis and Bleeding-free Fibrinolytic Treatment of Thrombosis
Conclusions: We describe a novel theranostic technology enabling simultaneous diagnosis and treatment of thrombosis, as well as monitoring of success or failure of thrombolysis. This technology holds promise for major progress in rapid diagnosis and bleeding-free thrombolysis thereby potentially preventing the often devastating consequences of thrombotic disease in many patients.
Source: Theranostics - June 5, 2016 Category: Molecular Biology Authors: Xiaowei Wang, Yannik Gkanatsas, Jathushan Palasubramaniam, Jan David Hohmann, Yung Chih Chen, Bock Lim, Christoph E Hagemeyer, Karlheinz Peter Tags: Research Paper Source Type: research

In vitro examination of the thrombolytic efficacy of tenecteplase and therapeutic ultrasound compared to rt-PA
Optimizing thrombolytic therapy is vital for improving stroke outcomes. We aimed to develop standardized thrombolysis conditions to evaluate the efficacy of tenecteplase (TNK) compared to the current gold stan...
Source: BMC Neurology - August 2, 2019 Category: Neurology Authors: Tobias Fr ühwald, Ulrich Gärtner, Nils Stöckmann, Jan-Henning Marxsen, Carolin Gramsch and Florian C. Roessler Tags: Research article Source Type: research

Ultrasound- Guided Sono- Photomechanic Combination Therapy Of Abdominal Aorta Atherothrombosis Accompanied By Simultaneously Plga- Based Encapsulated Tpa Nanoparticles And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. The aim of this study was to generate a hamster model of abdominal aorta atherothrombotic stenosis and the subsequent investigating the feasibility of sono- photomechanic combination thrombolytic therapy accompanied by simultaneously PLGA- based encapsulated tPA nanoparticles and microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research

B- Mode Ultrasound- Guided Catheter- Based Q-Switched Nd: Yag Laser- Mediated Inertial Cavitation Therapy Of Embolic Artery Accompanied By Simultaneously Streptokinase And Pesda Microbubbles Administration
Background and Aims: A plaque may rupture with high risk of subsequent thrombus mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. The aim of this study was to generate a rabbit model of femoral artery thromboembolism occlusion and the subsequent investigating the feasibility of Q-switched Nd: YAG laser thrombolytic therapy accompanied by simultaneously intravenous streptokinase and PESDA microbubbles administration in this model.
Source: Atherosclerosis - August 4, 2019 Category: Cardiology Authors: H. mehrad Tags: Posters 26 - 29 May, 2019 Source Type: research