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Therapy: Vagus Nerve Stimulation Therapy

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Total 158 results found since Jan 2013.

α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke
AbstractVagus nerve stimulation through the action of acetylcholine can modulate inflammatory responses and metabolism. α7 Nicotinic Acetylcholine Receptor (α7nAChR) is a key component in the biological functions of acetylcholine. To further explore the health benefits of vagus nerve stimulation, this study aimed to investigate whether α7nAChR agonists offer beneficial effects against poststroke inflammatory and m etabolic changes and to identify the underlying mechanisms in a rat model of stroke established by permanent cerebral ischemia. We found evidence showing that pretreatment with α7nAChR agonist, GTS-21, improv...
Source: Metabolic Brain Disease - January 20, 2023 Category: Neurology Source Type: research

Vagus Nerve Stimulation Paired with Upper-Limb Rehabilitation After Stroke: Two- and Three-Year Follow-up from the Pilot Study
CONCLUSIONS: Significant effects of Paired VNS therapy at one year were maintained at years 2 and 3, and further improvements in both impairment and function were observed in years 2 and 3. These changes were associated with improvements in measures of activity and participation.PMID:37001842 | DOI:10.1016/j.apmr.2023.02.012
Source: Health Physics - March 31, 2023 Category: Physics Authors: Gerard E Francisco Navzer Engineer Jesse Dawson Teresa J Kimberley Steven Cramer Cec ília N Prudente David Pierce Brent W Tarver Reema H Adham Hinds Ann Van de Winckel Nuray Yozbatiran Source Type: research

Vagus Nerve Stimulation Paired With Upper-Limb Rehabilitation After Stroke: 2- and 3-Year Follow-up From the Pilot Study
More than 50% of people post-stroke have significant limitations in their ability to carry out day-to-day functional activities long term and are unable to effectively incorporate their impaired hand and arm during everyday tasks.1,2 The disabling effects typically persist for many years after the initial stroke.3,4 People with stroke often compensate by using the less impaired limb for daily activities, which may precipitate learned non-use and result in further deterioration of arm and hand function.
Source: Archives of Physical Medicine and Rehabilitation - March 29, 2023 Category: Rehabilitation Authors: Gerard E. Francisco, Navzer D. Engineer, Jesse Dawson, Teresa J. Kimberley, Steven C. Cramer, Cec ília N. Prudente, David Pierce, W. Brent Tarver, Reema H. Adham Hinds, Ann Van de Winckel, Nuray Yozbatiran Tags: ORIGINAL RESEARCH Source Type: research

Combining high dose therapy, bilateral motor priming, and vagus nerve stimulation to treat the hemiparetic upper limb in chronic stroke survivors: a perspective on enhancing recovery
Stroke is a leading cause of disability worldwide and upper limb hemiparesis is the most common post-stroke disability. Recent studies suggest that clinically significant motor recovery is possible in chronic stroke survivors with severe impairment of the upper limb. Three promising strategies that have been investigated are (1) high dose rehabilitation therapy (2) bilateral motor priming and (3) vagus nerve stimulation. We propose that the future of effective and efficient upper limb rehabilitation will likely require a combination of these approaches.
Source: Frontiers in Neurology - June 28, 2023 Category: Neurology Source Type: research

Efficacy and safety of vagus nerve stimulation on upper extremity motor function in patients with stroke: A meta-analysis of randomized controlled trials
CONCLUSION: For stroke victims with upper limb disabilities, VNS paired with rehabilitation was significantly safe and effective. More high-quality multicentric RCTs are needed to validate this conclusion.PMID:37694313 | DOI:10.3233/NRE-230106
Source: NeuroRehabilitation - September 11, 2023 Category: Rehabilitation Authors: Tianqi We Xiangyang Ge Lingfeng Lu Jing Li Panpan Xu Qinfeng Wu Source Type: research

UT Dallas researchers find early success in new treatment for stroke recovery
(University of Texas at Dallas) Researchers at The University of Texas at Dallas conducted a study testing vagus nerve stimulation as a possible technique to improve recovery from stroke. The stimulation method already is approved for use in humans for treating a number of diseases. In the animal study, researchers found that pairing vagus nerve stimulation with physical rehabilitation returned all of the rats in the trial group to pre-stroke levels -- double the effectiveness of rehabilitation alone.
Source: EurekAlert! - Social and Behavioral Science - October 1, 2013 Category: Global & Universal Source Type: news