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Therapy: Vagus Nerve Stimulation Therapy

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Total 158 results found since Jan 2013.

Transcutaneous auricular vagus nerve stimulators: a review of past, present, and future devices
This article reviewed the history and classification of taVNS devices.EXPERT OPINION: The correlation between the effectiveness and stimulation parameters from taVNS devices still remains unclear. There is a lack of standard or harmonization among different taVNS devices. Strategies, including further comparative research and establishment of standard, have been recommended in this article to promote the future development of taVNS devices.PMID:34937487 | DOI:10.1080/17434440.2022.2020095
Source: Expert Review of Medical Devices - December 23, 2021 Category: Medical Devices Authors: Lei Wang Yu Wang Yifei Wang Fang Wang Jinling Zhang Shaoyuan Li Mozheng Wu Liang Li Peijing Rong Source Type: research

Transcutaneous auricular vagus nerve stimulation in poststroke cognitive impairment: protocol for a randomised controlled trial
Background As one of the most common stroke sequelae, poststroke cognitive impairment significantly impacts 17.6%–83% of survivors, affecting their rehabilitation, daily living and quality of life. Improving cognitive abilities among patients in stroke recovery is therefore critical and urgent. Transcutaneous auricular vagus nerve stimulation (TAVNS) is a non-invasive, safe, cost-effective treatment with great potential for improving the cognitive function of poststroke patients. This clinical research will evaluate the effectiveness, and help elucidate the possible underlying mechanisms, of TAVNS for improving posts...
Source: BMJ Open - October 5, 2022 Category: General Medicine Authors: Li, Z.-D., Qiu, H.-J., Wang, X.-Q., Zhang, C.-C., Zhang, Y.-J. Tags: Open access, Rehabilitation medicine Source Type: research

Electrical Stimulation of the Vagus Nerve Dermatome in the External Ear is Protective in Rat Cerebral Ischemia
Although cervical vagus nerve stimulation is effective for reducing infarct volume in rats, it is not feasible for acute human stroke as it requires surgical incision of the neck. We hypothesized that stimulation of the dermatome in the external ear innervated by the vagus nerve (auricular vagus nerve stimulation; aVNS) reduces infarct volume after transient focal ischemia in rats.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 25, 2014 Category: Neurology Authors: Ilknur Ay, Vitaly Napadow, Hakan Ay Tags: Original Research Source Type: research

Transcutaneous Cervical Vagus Nerve Stimulation Ameliorates Acute Ischemic Injury in Rats
Conclusions nVNS inhibits ischemia-induced immune activation and reduces the extent of tissue injury and functional deficit in rats without causing cardiac or hemodynamic adverse effects when initiated up to 4 hours after MCAO.
Source: Brain Stimulation - December 1, 2015 Category: Neurology Source Type: research

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation
Abstract Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one ...
Source: Neurotherapeutics - December 15, 2015 Category: Neurology Source Type: research

Non-invasive vagus nerve stimulation reduces blood-brain barrier disruption in a rat model of ischemic stroke
Vagus nerve stimulation (VNS) significantly reduces infarct volume in rat models of cerebral ischemia, but the mechanism of this protective effect remains open.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2018 Category: Neurology Authors: Yirong Yang, Lisa Y. Yang, Lilla Orban, Darnell Cuylear, Jeffrey Thompson, Bruce Simon, Yi Yang Source Type: research

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury
This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV ...
Source: eLife - March 13, 2018 Category: Biomedical Science Tags: Neuroscience Source Type: research

Recent advances in devices for vagus nerve stimulation.
Authors: Mertens A, Raedt R, Gadeyne S, Carrette E, Boon P, Vonck K Abstract INTRODUCTION: Vagus nerve stimulation (VNS) has become a valuable treatment option for refractory epilepsy and depression. To improve clinical efficacy and minimize side effects, novel device technology for vagus nerve stimulation is under development and investigation. Areas covered: For epilepsy, the AspireSR® and SenTiva™ VNS therapy systems are the 2 most recently developed VNS devices. These novel devices have implemented a closed-loop approach and contain a cardiac based seizure detection algorithm. The mechanism of action of VNS ...
Source: Expert Review of Medical Devices - August 4, 2018 Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research

Non-invasive Vagus Nerve Stimulation Protects Against Cerebral Ischemia/Reperfusion Injury and Promotes Microglial M2 Polarization Via Interleukin-17A Inhibition
In conclusion, our study identifies microglial M2 polarization as an important mechanism underlying the nVNS-mediated neuroprotection against cerebral I/R. This effect of nVNS could be attributed to the inhibition of IL-17A expression.
Source: Journal of Molecular Neuroscience - November 27, 2018 Category: Neuroscience Source Type: research

Development of Closed-loop Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) as a Neurorehabilitation Tool
Background: Motor rehabilitation training is considered the optimal method in reducing motor impairments in patients with brain injury. Noninvasive brain stimulation has recently demonstrated promise as a potential adjunct to enhance the outcomes of conventional post-stroke motor rehabilitation. Specifically, transcutaneous auricular vagus nerve stimulation (taVNS) paired with oromotor therapy to learn feeding behavior (Badran Jenkins, 2018) has emerged as a novel therapeutic avenue. Synchronization of taVNS with the specific motor behavior is believed to be critical to patient outcomes.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: B. Badran, D. Jenkins, W. DeVries, M. Dancy, D. Cook, G. Mappin, M. George Source Type: research

Vagus Nerve Stimulation as a Strategy to Augment Stroke Rehabilitation
Neural plasticity supports recovery after neurological injury. Strategies that enhance adaptive neural plasticity in conjunction with rehabilitation hold promise to substantially improve recovery of motor and sensory function after neurological damage. We have developed an innovative method using brief bursts of vagus nerve stimulation (VNS) paired with rehabilitative training to enhance plasticity in motor circuits. VNS drives phasic activation of plasticity-enhancing neuromodulatory systems which augment rehabilitation-dependent plasticity.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: S. Hays Source Type: research

Abstract #128: Chronic Vagus Nerve Stimulation Enables Long-term Plasticity in Mouse Auditory Cortex
Introduction: Vagus nerve stimulation is currently used as a medical treatment for those suffering from severe epilepsy or depression, but the mechanisms underlying vagus nerve stimulation are poorly understood. The vagus nerve helps connect essentially all peripheral organs to the central nervous system, sending afferents to the nucleus tractus solitarius. Recent studies indicate that vagus nerve stimulation can produce long-lasting plasticity in the cerebral cortex, leading to improved sensory processing and recovery of motor behavior after stroke (Boreland et al, Brain Stimul (2016).
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Eleni S. Papadoyannis, Kathleen A. Martin, Jennifer K. Schiavo, Nesibe Z. Temiz, Robert C. Froemke Source Type: research

Transcutaneous auricular vagus nerve stimulation in treating post-stroke insomnia monitored by resting-state fMRI: The first case report
Publication date: May–June 2019Source: Brain Stimulation, Volume 12, Issue 3Author(s): Bin Zhao, Liang Li, Yue Jiao, Man Luo, Ke Xu, Yang Hong, Jiu-Dong Cao, Yue Zhang, Ji-Liang Fang, Pei-Jing Rong
Source: Brain Stimulation - April 24, 2019 Category: Neurology Source Type: research

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