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Condition: Depression

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Total 18 results found since Jan 2013.

Multiscale effects of excitatory-inhibitory homeostasis in lesioned cortical networks: A computational study
We present a large-scale model of the neocortex, with synaptic scaling of local inhibition, showing how E-I homeostasis can drive the post-lesion restoration of FC and linking it to changes in excitability. We show that functional networks could reorganize to recover disrupted modularity and small-worldness, but not network dynamics, suggesting the need to consider forms of plasticity beyond synaptic scaling of inhibition. On average, we observed widespread increases in excitability, with the emergence of complex lesion-dependent patterns related to biomarkers of relevant side effects of stroke, such as epilepsy, depressio...
Source: PLoS Computational Biology - July 7, 2023 Category: Biology Authors: Francisco P áscoa dos Santos Source Type: research

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs
by Niklas Hübel, Markus A. Dahlem The classical Hodgkin-Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied by the resistance of the ion channels, and by the gating time constants. We study slow dynamics in an extended HH framework that includes time-dependent ion concentrations, pumps, and buffers. Fluxes across the neuronal membrane change intra- and extracellular ion concentrations, whereby the latter can also change through contact to reservoirs in the sur...
Source: PLoS Computational Biology - December 4, 2014 Category: Biology Authors: Niklas Hübel et al. Source Type: research

Winter metabolic depression does not change arterial baroreflex control of heart rate in the tegu lizard (Salvator merianae) RESEARCH ARTICLE
Lucas A. Zena, Valter Dantonio, Luciane H. Gargaglioni, Denis V. Andrade, Augusto S. Abe, and Kenia C. BicegoBaroreflex regulation of blood pressure (BP) is important for maintaining appropriate tissue perfusion. Although temperature affects heart rate (fH) reflex regulation in some reptiles and toads, no data are available on the influence of temperature-independent metabolic states on baroreflex. The South American tegu lizard Salvator merianae exhibits a clear seasonal cycle of activity decreasing fH along with winter metabolic downregulation, independent of body temperature. Through pharmacological interventions (pheny...
Source: Journal of Experimental Biology - January 8, 2016 Category: Biology Authors: Zena, L. A., Dantonio, V., Gargaglioni, L. H., Andrade, D. V., Abe, A. S., Bicego, K. C. Tags: RESEARCH ARTICLE Source Type: research

Cerebroprotection of flavanol (-)-epicatechin after traumatic brain injury via Nrf2-dependent and -independent pathways.
Abstract Traumatic brain injury (TBI), which leads to disability, dysfunction, and even death, is a prominent health problem worldwide with no effective treatment. A brain-permeable flavonoid named (-)-epicatechin (EC) modulates redox/oxidative stress and has been shown to be beneficial for vascular and cognitive function in humans and for ischemic and hemorrhagic stroke in rodents. Here we examined whether EC is able to protect the brain against TBI-induced brain injury in mice and if so, whether it exerts neuroprotection by modulating the NF-E2-related factor (Nrf2) pathway. We used the controlled cortical impac...
Source: Free Radical Biology and Medicine - December 25, 2015 Category: Biology Authors: Cheng T, Wang W, Li Q, Han X, Xing J, Qi C, Lan X, Wan J, Potts A, Guan F, Wang J Tags: Free Radic Biol Med Source Type: research

Winter metabolic depression does not change arterial baroreflex control of heart rate in the tegu lizard Salvator merianae RESEARCH ARTICLE
Lucas A. Zena, Valter Dantonio, Luciane H. Gargaglioni, Denis V. Andrade, Augusto S. Abe, and Kenia C. Bicego Baroreflex regulation of blood pressure is important for maintaining appropriate tissue perfusion. Although temperature affects heart rate (fH) reflex regulation in some reptiles and toads, no data are available on the influence of temperature-independent metabolic states on baroreflex. The South American tegu lizard Salvator merianae exhibits a clear seasonal cycle of activity decreasing fH along with winter metabolic downregulation, independent of body temperature. Through pharmacological interventions (phenyleph...
Source: Journal of Experimental Biology - March 2, 2016 Category: Biology Authors: Zena, L. A., Dantonio, V., Gargaglioni, L. H., Andrade, D. V., Abe, A. S., Bicego, K. C. Tags: RESEARCH ARTICLE Source Type: research

The beneficial hemodynamic effects of afterload reduction by sodium nitroprusside during rewarming from experimental hypothermia.
CONCLUSION: When rewarming the present model of HCD a significant increase in SVR takes place. In this context, pharmacologic intervention aimed at reducing SVR show clear positive results on CO and SV. However, a reduction in SVR alone is not sufficient to fully alleviate CO during HCD, and indicate the need of additional inotropic support. PMID: 28479295 [PubMed - as supplied by publisher]
Source: Cryobiology - May 4, 2017 Category: Biology Authors: Håheim B, Kondratiev T, Dietrichs ES, Tveita T Tags: Cryobiology Source Type: research

A Kirchhoff-Nernst-Planck framework for modeling large scale extracellular electrodiffusion surrounding morphologically detailed neurons
by Andreas Solbr å, Aslak Wigdahl Bergersen, Jonas van den Brink, Anders Malthe-Sørenssen, Gaute T. Einevoll, Geir Halnes Many pathological conditions, such as seizures, stroke, and spreading depression, are associated with substantial changes in ion concentrations in the extracellular space (ECS) of the brain. An understanding of the mechanisms that govern ECS concentration dynamics may be a prerequisite for underst anding such pathologies. To estimate the transport of ions due to electrodiffusive effects, one must keep track of both the ion concentrations and the electric potential simultaneously in the relevant regio...
Source: PLoS Computational Biology - October 4, 2018 Category: Biology Authors: Andreas Solbr å Source Type: research

Association Between Trace Element Status and Depression in HTLV-1-Infected Patients: a Retrospective Cohort Study.
Abstract Depression and Anxiety are two important public health problems that are known to be associated with viral infections. The association between the intake of nutrients such as zinc and copper with symptoms of depression has been studied previously. The aim of the current study was to investigate the association between depression with human T cell lymphotropic virus type 1 (HTLV-1) infection and serum content of zinc and copper in a large Iranian population cohort. The study population consisted of 279 HTLV-1-positive patients who were identified after recruitment as part of a large cohort study: the Mashh...
Source: Biological Trace Element Research - February 4, 2019 Category: Biology Authors: Darroudi S, Abolbashari S, Ahangari N, Tayefi M, Khashyarmanesh Z, Zamani P, Haghighi HM, Mohammadpour AH, Tavalaei S, Esmaily H, Ferns GA, Meshkat Z, Tayefi B, Ghayour-Mobarhan M Tags: Biol Trace Elem Res Source Type: research

The effects of cerebral curvature on cortical spreading depression
In this study a large scale numerical NVC model of multiple NVUs is coupled to a vascular tree simulating a two-dimensional cerebral tissue slice. This model is extended with a spatial Gaussian curvature mapping that can simulate the highly folded nature of the human cortex. For a flat surface comparable to a lissencephalic cortex the model can simulate propagating waves of high extracellular K+ travelling radially outwards from a stimulated area at approximately 6.7 mm/min, corresponding well with multiple experimental results. The high K+ concentration induces a corresponding wave of vasoconstriction (with decreased bloo...
Source: Journal of Theoretical Biology - April 9, 2019 Category: Biology Source Type: research

A mathematical model for persistent post-CSD vasoconstriction
by Shixin Xu, Joshua C. Chang, Carson C. Chow, Kevin C. Brennan, Huaxiong Huang Cortical spreading depression (CSD) is the propagation of a relatively slow wave in cortical brain tissue that is linked to a number of pathological conditions such as stroke and migraine. Most of the existing literature investigates the dynamics of short term phenomena such as the depolarization and repolarization of membrane potentials or large ion shifts. Here, we focus on the clinically-relevant hour-long state of neurovascular malfunction in the wake of CSDs. This dysfunctional state involves widespread vasoconstriction and a general disr...
Source: PLoS Computational Biology - July 14, 2020 Category: Biology Authors: Shixin Xu Source Type: research

A community-based study of demographics, medical and psychiatric conditions, and gender dysphoria/incongruence treatment in transgender/gender diverse individuals
ConclusionTransgender and gender diverse individuals represent a population who express various gender identities and are seeking gender-specific healthcare at increasing rates. Psychiatric illness is highly prevalent compared to the US population but there is no difference in the prevalence of CV risk factors including obesity, type 2 diabetes, hypertension, and dyslipidemia.
Source: Biology of Sex Differences - October 5, 2020 Category: Biology Source Type: research

Effects of Combined Sertraline and Magnesium in Rat Atrium
The objective of this study is to determine the synergistic effects of an antioxidant ion Mg+2, combined with selective serotonin reuptake inhibitor sertraline, in treatment or prevention of major depression and regulation of inotropic effect in the early postoperative period. Adult male 40 Wistar albino rats were randomly divided into 6 groups. Three to 4-mm long atrium strips were placed in organ bath, tension was adjusted to 2 g. Isometric contractions were induced with 10-3 M adrenaline. Group 1 was the control group, cumulative sertraline was given to group 2, cumulative MgSO4 to group 3, combined cumulative sertralin...
Source: Biological Trace Element Research - March 28, 2021 Category: Biology Authors: Esra Fidan Z Isik Solak Gormus İbrahim Kilinc Mehmet Sinan İyisoy Niyazi Gormus Source Type: research

Hypothermia Promotes Mitochondrial Elongation In Cardiac Cells Via Inhibition Of Drp1
In conclusion hypothermia promoted elongation of cardiac mitochondria via reduced pDrp1S616 abundance which was also associated with suppression of cellular oxygen consumption. Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates a novel mechanism of cold-induced inhibition of mitochondrial fission.PMID:34331901 | DOI:10.1016/j.cryobiol.2021.07.013
Source: Cryobiology - July 31, 2021 Category: Biology Authors: David Taylor Juliana Germano Yang Song Hanane Hadj-Moussa Stefanie Marek-Iannucci Raeesa Dhanji Jon Sin Lawrence S C Czer Kenneth B Storey Roberta A Gottlieb Source Type: research

BMI Modifies the Association Between Depression Symptoms and Serum Copper Levels
Biol Trace Elem Res. 2022 Nov 27. doi: 10.1007/s12011-022-03505-y. Online ahead of print.ABSTRACTDepression is one of the most common mental disorders which dramatically threatens public health and wellness. Copper has been known to be involved in many biological processes that could help explaining the occurrence of depression. However, studies focusing on its effect have yielded mixed results. The present study aims to evaluate the association between serum copper levels and depression symptoms. It also investigates the effect of modification of BMI (body mass index) on depression symptoms. A total of 5419 US adults aged...
Source: Biological Trace Element Research - November 27, 2022 Category: Biology Authors: Wu Hongrong Li Qingqi Gao Rong Tang Shuangyang Zhang Kaifang Zhao Jianfeng Source Type: research