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Total 204 results found since Jan 2013.

Rates of Referral to Coronary Angiography After Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI)
Conclusions: About 1 in 5 patients undergoing PET MPI are referred for coronary angiography within 90 days of testing, a rate greater than that reported for SPECT MPI, likely due to higher baseline risk of patients undergoing PET MPI testing. While referral rates for coronary angiography varied based on the presence or absence of prior documented clinical CAD and presence of test abnormalities, nearly 36% of patients with moderate-severe ischemia were not referred. Further work is needed to characterize why such patients are not referred for invasive evaluation to optimize the use of PET MPI in this high-risk population.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Patel, K., Spertus, J., Kureshi, F., Al Badarin, F., McGhie, A., Kennedy, K., Courter, S., Case, J., Thompson, R., Chan, P., Bateman, T. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Evaluation of 11CTMI as a COX-2 selective PET tracer in baboon
Conclusion: Our PET imaging studies in baboon show that [11C]TMI penetrates the BBB and distributes to COX-2 enriched brain regions. Details of the in vivo evaluation of [11C]TMI in baboon brain will be presented. References 1. Majo VJ et al., Bioorg Med Chem Let., 2005, 15, 4268. 2. Cunningham VJ et al., J Cereb Blood Flow Metab., 2010; 30(1): 46-50. Grant Support: Diane Goldberg Foundation (NYSPI/CUMC) and Pfizer Inc.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Kumar, D., Zanderigo, F., Prabhakaran, J., Rubin-Falcone, H., Parsey, R., Mann, J. J. Tags: Neuroscience - Basic Science - Posters Source Type: research

Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

18 F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques
Conclusions18F-NaF PET represents a different stage in the calcification process than CT. We observed a similar PET assessed18F-NaF uptake and pattern in culprit and non-culprit plaques of high-risk patients, indicating that this method may be of more value in early atherosclerotic stenosis development.
Source: Journal of Nuclear Cardiology - June 25, 2018 Category: Nuclear Medicine Source Type: research

Nutrition, risk factors, prevention, and imaging: The 2018 Mario Verani Lecture
AbstractHeart disease has been the leading cause of death in the United States since 1918. Cardiac mortality rates have dramatically decreased in this era of advanced medical and interventional therapies. However, this has been aptly described as “mopping up the floor instead of turning off the faucet.” With this recognition, prevention in cardiology is poised to become a central focus. Within prevention, dietary intervention is recognized as the single largest opportunity for improved cardiovascular outcomes, including improvement or el imination of cardiac risk factors, prevention of myocardial infarction, stroke and...
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Brain Theranostics and Radiotheranostics: Exosomes and Graphenes In Vivo as Novel Brain Theranostics
AbstractBrain disease is one of the greatest threats to public health. Brain theranostics is recently taking shape, indicating the treatments of stroke, inflammatory brain disorders, psychiatric diseases, neurodevelopmental disease, and neurodegenerative disease. However, several factors, such as lack of endophenotype classification, blood-brain barrier (BBB), target determination, ignorance of biodistribution after administration, and complex intercellular communication between brain cells, make brain theranostics application difficult, especially when it comes to clinical application. So, a more thorough understanding of...
Source: Nuclear Medicine and Molecular Imaging - November 9, 2018 Category: Nuclear Medicine Source Type: research

Simultaneous 18F-FDG PET/MRI Assists Diagnosis of a Rare Disease, MELAS
MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) is a rare congenital mitochondrial DNA mutation disease. Here, we report a 4-year-old girl, who presented with short stature, mental retardation, and recurrent seizures, underwent simultaneous 18F-FDG PET/MRI examination. An interesting contradiction images were found on bilateral frontal, left temporal, occipital, and parietal lobes, which were with high blood flow shown on 3D-ASL perfusion images, but low uptake of 18F-FDG on PET images. The contradiction of high blood flow and low glucose metabolism gave us a clue to make the diagnosis of...
Source: Clinical Nuclear Medicine - December 23, 2018 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Comparison of 11C(R)-NR2B-SMe and 11C(R)-NR2B-Me as PET radioligands for imaging NR2B subunits in NMDA receptors
Conclusions: [11C](R)-NR2B-SMe and [11C](R)-NR2B-Me were readily synthesized and they showed high brain uptakes in rat, which could be pre-blocked by self, NR2B-selective ligands, or either of two sigma-1 receptor agonists. Sigma-1 antagonists showed no blocking effect at low dose, but some blocking effect at high dose. More studies are necessary to elucidate the selectivity of the two radioligands and the blocking effects of some sigma-1 receptor agonists. Research Support: Intramural Research Program of the National Insitutes of Health (NIMH). References: [1] Zhuo M, Neuropharmacology, 2017, 112, 228. [2] Kassenbrock A, ...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C., Davies, R., Telu, S., Frankland, M., Zoghbi, S., Innis, R., Pike, V. Tags: Basic Science II (Neurosciences) Source Type: research

Evaluation of hybrid 18F-FDG PET/MR imaging of vulnerable plaque features in patients with carotid plaques
Conclusions: Morphological and biological features of vulnerable plaques can be detected with 18F-FDG PET/MRI in patients with known increased risk of atherosclerosis. Hybrid 18F-FDG PET/MRI systems might help in the evaluation of patients with vulnerable carotid atherosclerotic plaques. Key words: Atherosclerosis, Vulnerable plaque, Carotid arteries, Positron emission tomography, Magnetic resonance imaging, PET/MR, 18F-FDG
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Zhang, Y., Lu, J., Yang, H., Ma, J., Song, H., Ma, Q. Tags: Cardiovascular Clinical Science: Vulnerable Plaque and Innervation Imaging Source Type: research

Preclinical evaluation of a new 18F-labled probe as a potent PET imaging ligand for GluN2B subunit in NMDA receptors
Conclusions: [18F]1 showed high selective and specific binding to GluN2B subunit in in vitro ARG with brain sections of both rat and NHP, which could be preciously blocked by compound 1 itself and BMT-108908. Furthermore, [18F]1 possessed good capability of BBB penetration and fast washout rate from the mice brain. These results suggested that [18F]1 had great potential utility in PET imaging of GluN2B subunit. Acknowledgments: We thank Drs. Thomas Brady (Nuclear Medicine, MGH) for his helpful discussion. References: 1. Mony L et al. Br. J. Pharmacol. 2009;157:1301-1317.2. Marcin LR et al. ACS Med. Chem. Lett. 2018;9:472-4...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Fu, H., Shao, T., Chen, Z., Shao, Y., Sun, S., Josephson, L., Wey, H.-Y., Daunais, J., Li, Z., Liang, S. Tags: Preclinical Probes for Neuroimaging Posters Source Type: research

Alzheimers Disease: A Review of Recent Developments and the Role of Imaging
1114Purpose: Alzheimer’s disease (AD), the most common form of dementia, is a devastating illness that will affect an estimated 5.7 million Americans and almost 50 million people worldwide in 2018, with numbers expected to nearly triple by 2050. While mortality related to heart disease and stroke has continued to decline, the rate of AD-related death in the United States more than doubled in the period from 2000-2015. Now the 6th leading cause of death, it is the least preventable and treatable of the major causes, and places a tremendous financial, physical, and emotional burden on the estimated 16 million unpaid ca...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Ismail, H., Wang, L. Tags: Educational Exhibit Posters Source Type: research

Current Challenges for Imaging of Hypoxia in 2019
1128Introduction: Tissues with low levels of oxygen often respond poorly to radiation therapy and chemo / immune therapies. Hypoxia in tumor bearing tissue is associated with worse clinical outcome and this has been known for over 50 years. Alterations to radiation therapy planning via providing localized boost to hypoxic tissues cannot be made without knowing exactly where hypoxia exists. However, there is no FDA approved agent to assess for hypoxia in tumor tissues, there is no accepted standard methodology for measuring hypoxia in patients, nor are there FDA approved agents for treating hypoxia. There are multiple PET i...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Rodgers, B., Kotlyarov, E. Tags: Educational Exhibit Posters Source Type: research

Carotid plaque inflammation is associated with inflammatory activity of visceral adipose tissue
Conclusions: We demonstrated that atherosclerotic plaque inflammation was associated with increased inflammation within visceral fat. Our results need to be confirmed by comparison with histologic or other imaging findings. Further evaluation to determine whether metabolic activity of visceral adipose tissue is a marker of mediator of vascular inflammation is also needed.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Pahk, K., Cho, H. Y., Kwon, H. R., Choi, S., Kwon, H. W., Eo, J. S., Seo, H. S., Kim, S., Kim, W.-K. Tags: Cardiovascular Clinical Science Posters Source Type: research

The Use of Random Forests to Classify Amyloid Brain PET
Conclusions Random forests can classify brain PET as positive or negative for amyloid deposition and suggest key clinically relevant, regional features for classification.
Source: Clinical Nuclear Medicine - September 11, 2019 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Unilateral Absence of the Basal Ganglia on 123I-Ioflupane DaTScan
This 33-year-old man presented with hemorrhagic stroke manifesting with left hemiparesis and right ptosis. Angiography revealed no patent carotids. The anterior and middle cerebral arteries were filling collaterally through the posterior vertebrobasilar pathway. The presumptive diagnosis was moyamoya disease. The etiology of the bleeding was right basilar tip aneurysm that subsequently had partial coil placement. Months later, the neck of the aneurysm perforated and second coiling was performed. Later on follow-up, patient developed left hand tremor. A radionuclide DATscan revealed total absence of right-sided basal gangli...
Source: Clinical Nuclear Medicine - September 11, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research