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Specialty: Nuclear Medicine
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Total 204 results found since Jan 2013.
Molecular imaging of inflammation in the brain-heart axis after ischemic stroke: comparison of two murine stroke models.
Conclusions: In contrast to topical ET-1 application after craniotomy, the intravascular MCAo model enables imaging studies of brain-heart networking after stroke, which evokes elevated TSPO PET signal in both brain and heart. The severity of cerebral ischemic damage may contribute to cardiac dysfunction via systemic inflammatory networking.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Hermanns, N., Bascunana, P., Langer, B. L. N., Wolf, B., Bankstahl, J., Ross, T., Bengel, F., Thackeray, J. Tags: Cardiovascular Council YIA Symposium Source Type: research
Causal role of non-stenotic hypodense plaques with high FDG uptake detected with PET-CT angiography in patients with unknown cause of stroke?
Conclusions In this exploratory study, we found a high prevalence of non-stenotic hypodense plaques with high FDG uptake (TBR max. > 1.80) in carotid arteries ipsilateral to cerebral ischemia suggesting a causal role for these plaque in patients with unknown cause of stroke. In comparison to high-resolution MRI, the imaging criteria used in this study for the identification of complicated plaques were very simple and easy to implement. In addition, FDG-PET-CTA allows for the evaluation of non-stenotic plaques along the whole length of supra-aortic trunks. Further studies with a larger number of patients are requested to...
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Mikail, N., Mazighi, M., Meseguer, E., Guidoux, C., Leseche, G., Rouzet, F., Le Guludec, D., Amarenco, P., Hyafil, F. Tags: MTA II: Cardiovascular Clinical Science Posters Source Type: research
Monitoring synaptic loss in a rat model of stroke: a PET imaging study with 18FSynVesT-2, radiotracer for the synaptic vesicle protein 2A (SV2A)
Conclusions: Using [18F]SynVesT-2 and PET imaging, we successfully detected synapse loss in rat MCAO model and tracked disease progression via lesion quantification. Synapse loss is mainly in hippocampus, thalamus, and neocortex, rather than cerebellum. Furthermore, most significant loss of synapses was observed to occur during the first week post reperfusion. Our results showed that the quantification of synaptic density by SV2A PET may provide an objective measure of disease progression and a primary endpoint to evaluate treatment efficacy of novel therapeutics for stroke in clinical trials. References: Bunevicius et al....
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Lyu, X., Toyonaga, T., Deng, G., Huang, Y., Carson, R., Zhou, J., Cai, Z. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research
FDG PET Imaging as A Non-invasive Method to Demonstrate Peri-infarct Depression after Stroke
Conclusion: FDG PET imaging is reliable to reflect metabolic stress imposed by peri-infarct depression. Peri-infarct depression leads to the metabolic change in neurons, including suppression of mitochondria function and overactivation of glycolysis, thus deteriorate functional and tissue consequence. The insults from PID could be alleviated by improving mitochondria function.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Yao, J., Zhou, R., Shi, J., Zhang, H. Tags: Basic Science III Source Type: research
18 F-FDG PET/CT imaging factors that predict ischaemic stroke in cancer patients
ConclusionOur findings suggest that arterial FDG uptake and hypermetabolic malignancy on PET and the VAT proportion on CT could be independent predictors of future ischaemic stroke in patients with cancer and could identify those patients who would benefit from medical treatment.
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 4, 2016 Category: Nuclear Medicine Source Type: research
Evaluation of non-stenotic carotid atherosclerotic plaques with combined FDG-PET imaging and CT angiography in patients with ischemic stroke of unknown origin
ConclusionsIn patients with ischemic stroke of unknown origin and non-stenotic plaques, we found an increased prevalence of high-risk plaques features ipsilateral vs. contralateral to stroke on FDG-PET-CTA imaging suggesting a causal role for these plaques.
Source: Journal of Nuclear Cardiology - January 18, 2021 Category: Nuclear Medicine Source Type: research
PET imaging of ischemic brain stroke necrosis with novel agent 18F-Fluoroglucaric Acid
Conclusions: Results show that FGA has a potential to enable extremely sensitive and high resolution neuroimaging of brain infarcts. F-18-labeled FGA can be rapidly synthesized from ubiquitously available F-18-FDG in a simple reaction.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Houson, H., Mdzinarishvili, A., Awasthi, V. Tags: Basic Science III Source Type: research
18FDBT10 as alpha7-nAChR ligand to image stroke-associated neuroinflammation by PET
616Objectives: t is known that, after ischemic stroke, neuroinflammatory processes occur which represent interesting treatment targets. However, sufficient in vivo imaging of these processes, particularly in acute and subacute stages, was not possible upon till now. During neuroinflammation, alpha7-nicotinic acetylcholine receptors (nAChRs) are overexpressed. We, thus, tested the novel alpha7-nAChR ligand [18F]DBT10 for its potential to image post-stroke neuroinflammation. In 10 adult Merino sheep, the left middle cerebral artery was permanently occluded (pMCAO, day 1). On day 0 (baseline) as well as 4hrs after pMCAO, and ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Barthel, H., Deuther-Conrad, W., Patt, M., Nitzsche, B., Teodoro, R., Hartig, W., Wenzel, B., Aleithe, S., Mages, B., Luthardt, J., Rullmann, M., Becker, G., Grunwald, T., Michalski, D., Boltze, J., Brust, P., Sabri, O. Tags: Probes for Neuroimaging II Source Type: research
FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation
ConclusionsThis study shows a significant correlation between FDG atrial uptake and AF. While inconsistent, this pattern seems to be associated with an increased prevalence of cardioembolic stroke.
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 27, 2019 Category: Nuclear Medicine Source Type: research
Antioxidative neuroprotective role of iron-gallic acid coordination nanoparticles and PET/MR usage in an ischemia stroke model
Conclusions: Fe-GA CPNs exhibit an impressive antioxidative neuroprotective role in ischemia stroke, which might have the potential to be translated into clinical applications for improved treatment of patients with stroke. PET/MRI is effective and accurate method for ischemic evaluation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: KANG, L., Jiang, D., NI, D., Ehlerding, E., Wang, R., Cai, W. Tags: Basic Science I (Neurosciences) Source Type: research
Framework DNA nanocages alleviate ischemic stroke via intrathecal injection
Conclusions: Zr-89 and 800CW labeled DNA nanocage framework could be safely delivered to rat brains via intrathecal injection and imaged using PET imaging and fluorescence imaging. The delivered DNA nanocages may protected rats from ischemic stroke by neutralizing ROS. This DNA framework holds great promise for stroke prevention and potential clinical translation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Jiang, D., NI, D., Li, S., Ehlerding, E., Sun, T., Cao, T., Chen, W., Engle, J., Cai, W. Tags: Novel Multimodality and Nonradioactive Probes Source Type: research
Association of atrial 18F-fluorodeoxyglucose uptake and prior ischemic stroke in non-atrial fibrillation patients
ConclusionsThis study identified an association between atrial FDG activity and a history of ischemic stroke and atrial cardiomyopathy in non-AF individuals. Further longitudinal study is warranted to demonstrate their causal relationship.
Source: Journal of Nuclear Cardiology - January 26, 2022 Category: Nuclear Medicine Source Type: research
Added value of CT perfusion and CT angiography in detection of early ischemic stroke: Comparison with noncontrast CT
Conclusion CT perfusion and CTA provide effective diagnostic tools in acute stroke with increased sensitivity to detect acute cerebral ischemia compared with noncontrast CT alone.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - August 19, 2015 Category: Nuclear Medicine Source Type: research
Efficacy and safety of carotid artery stenting for stroke prevention
Conclusion Careful patient selection and technique optimization are crucial to improve clinical outcome which make it a safe alternative for surgical revascularization in stroke prevention.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - December 11, 2015 Category: Nuclear Medicine Source Type: research
