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Specialty: Neuroscience
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Total 206 results found since Jan 2013.

Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke
mp; Cesare Patrone
Source: Journal of Cerebral Blood Flow and Metabolism - April 30, 2015 Category: Neuroscience Authors: Vladimer DarsaliaMartin LarssonDavid NathansonThomas KleinThomas NyströmCesare Patrone Tags: diabetes DPP-4 inhibitors exendin-4 GLP-1 liraglutide neuroprotection stroke Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

Prolyl Carboxypeptidase Activity Decline Correlates with Severity and Short-Term Outcome in Acute Ischemic Stroke.
Abstract Prolyl carboxypeptidase (PRCP) is an enzyme associated with cerebrovascular risk factors such as hypertension, diabetes mellitus, obesity and hyperlipidemia. We aim to evaluate the relation between serum PRCP activity and severity, evolution and outcome of acute ischemic stroke. We used a specific RP-HPLC activity assay to measure PRCP activity in serum of 50 stroke patients at admission, and at 24 h, 72 h and 7 days after stroke onset to assess correlations with stroke severity based on the National Institutes of Health Stroke scale score (NIHSS), infarct volume on brain MRI scan, stroke outcome based...
Source: Neurochemical Research - November 5, 2014 Category: Neuroscience Authors: Kehoe K, Brouns R, Verkerk R, Engelborghs S, De Deyn PP, Hendriks D, De Meester I Tags: Neurochem Res Source Type: research

Stroke-Related Disease Comorbidity and Secondary Stroke Prevention Practices Among Young Stroke Survivors
Conclusions: Many young stroke survivors exhibit comorbid disease conditions that are similar to older stroke survivors. A large percentage are engaged in general chronic disease and secondary stroke prevention practices, yet less than two-thirds had seen a general doctor in the past 12 months. Primary care doctors and other health professionals are critical to the implementation of disease management strategies that consider their age, secondary stroke risk, expected life spans, and other issues that differ from older adult stroke survivors.
Source: Journal of Neuroscience Nursing - September 8, 2017 Category: Neuroscience Tags: Article Source Type: research

Regulation of DAPK1 by Natural Products: An Important Target in Treatment of Stroke
Neurochem Res. 2022 Jun 8. doi: 10.1007/s11064-022-03628-7. Online ahead of print.ABSTRACTStroke is a sudden neurological disorder that occurs due to impaired blood flow to an area of the brain. Stroke can be caused by the blockage or rupture of a blood vessel in the brain, called ischemic stroke and hemorrhagic stroke, respectively. Stroke is more common in men than women. Atrial fibrillation, hypertension, kidney disease, high cholesterol and lipids, genetic predisposition, inactivity, poor nutrition, diabetes mellitus, family history and smoking are factors that increase the risk of stroke. Restoring blood flow by repos...
Source: Neurochemical Research - June 8, 2022 Category: Neuroscience Authors: Tayebeh Noori Samira Shirooie Antoni Sureda Eduardo Sobarzo-Sanchez Ahmad Reza Dehpour Marianela Sald ías Esra K üpeli Akkol Source Type: research

Description and Identification of the Peripheral Immune Response Trajectories Over Time in First-Time and Recurrent Stroke/Transient Ischemic Attack
ABSTRACT: A unique extant database to explain heterogeneity in peripheral immune response (PIR) over time in response to stroke/transient ischemic attack (TIA) was used to compare changes in PIR between first-time and recurrent stroke/TIA and to identify distinct and common trajectories of change in the PIR in stroke/TIA. Associations between risk factors for stroke (hypertension, smoking, diabetes, hypercholesterolemia, infection) and PIR trajectory were quantified using multivariate random effects modeling. With comparable admission values, patients with recurrent stroke/TIA had a persistent elevation in lymphocyte perce...
Source: Journal of Neuroscience Nursing - September 9, 2015 Category: Neuroscience Tags: Article Source Type: research

Treatment with an Angiopoietin-1 mimetic peptide promotes neurological recovery after stroke in diabetic rats.
CONCLUSION: Delayed VT treatment (24 h after stroke) significantly improves neurological function, promotes vascular and white matter remodeling, and decreases inflammation in the ischemic brain after stroke in T1DM rats. PMID: 33346402 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 21, 2020 Category: Neuroscience Authors: Venkat P, Ning R, Zacharek A, Culmone L, Liang L, Landschoot-Ward J, Chopp M Tags: CNS Neurosci Ther Source Type: research

Recurrent Stroke was Associated with Poor Quality of Life in Patients with Transient Ischemic Attack or Minor Stroke: Finding from the CHANCE Trial.
CONCLUSIONS: Stroke recurrence was associated with poor HRQOL in patients with TIA or minor strokes. Interventions focusing on controlling risk factors and prevention of worsening of neurological function may prevent poor HRQOL in these patients. PMID: 25307297 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - October 13, 2014 Category: Neuroscience Authors: Wang YL, Pan YS, Zhao XQ, Wang D, Johnston SC, Liu LP, Meng X, Wang AX, Wang CX, Wang YJ, The CHANCE investigators Tags: CNS Neurosci Ther Source Type: research

Role of serum ‐ and glucocorticoid‐inducible kinases in stroke
Abstract Increased expression of serum‐ and glucocorticoid‐inducible kinase 1 (SGK1) can be induced by stress and growth factors in mammals, and plays an important role in cancer, diabetes, and hypertension. A recent work suggested that SGK1 activity restores damage in a stroke model. To further investigate the role of SGKs in ischemic brain injury, we examined how SGK inhibitors influence stroke outcome in vivo and neurotoxicity in vitro. Infarct volumes were compared in adult mice with middle cerebral artery occlusion, followed by 24 h reperfusion, in the absence or presence of SGK inhibitors. Neurotoxicity assay,...
Source: Journal of Neurochemistry - May 24, 2016 Category: Neuroscience Authors: Koichi Inoue, Tiandong Leng, Tao Yang, Zhao Zeng, Takatoshi Ueki, Zhi ‐Gang Xiong Tags: Original Article Source Type: research

Impact of risk factors for recurrence after the first ischemic stroke in adults: A systematic review and meta-analysis
Publication date: Available online 16 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Shengbang Zheng, Baodong YaoAbstractRisk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the...
Source: Journal of Clinical Neuroscience - October 17, 2018 Category: Neuroscience Source Type: research

Lipid-Modifying Therapies and Stroke Prevention
AbstractPurpose of ReviewWe reviewed lipid-modifying therapies and the risk of stroke and other cerebrovascular outcomes, with a focus on newer therapies.Recent FindingsStatins and ezetimibe reduce ischemic stroke risk without increasing hemorrhagic stroke risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors similarly reduce ischemic stroke risk in statin-treated patients with atherosclerosis without increasing hemorrhagic stroke, even with very low achieved low-density lipoprotein cholesterol levels. Icosapent ethyl reduces the risk of total and first ischemic stroke in patients with established cardiova...
Source: Current Neurology and Neuroscience Reports - May 13, 2022 Category: Neuroscience Source Type: research