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Total 20 results found since Jan 2013.

Effects of Cerebellar Transcranial Direct Current Stimulation in Patients with Stroke: a Systematic Review
CONCLUSIONS: ctDCS appears to improve poststroke language and motor dysfunction (particularly gait). However, the evidence for these results was insufficient, and the quality of the relevant studies was low. ctDCS stimulation parameters and individual factors of participants may affect the therapeutic effect of ctDCS. Researchers need to take a more regulated approach in the future to conduct studies with large sample sizes. Overall, ctDCS remains a promising stroke intervention technique that could be used in the future.PMID:36028789 | DOI:10.1007/s12311-022-01464-7
Source: Cerebellum - August 26, 2022 Category: Neuroscience Authors: Li Hong-Yu Zhang Zhi-Jie Li Juan Xiong Ting He Wei-Chun Zhu Ning Source Type: research

Feasibility of Cerebellar Transcranial Direct Current Stimulation to Facilitate Goal-Directed Weight Shifting in Chronic Post-Stroke Hemiplegics
The objectives of this work were to (1) present a refined Virtual Reality (VR)-based balance training platform (VBaT) that can measure Center of Pressure (CoP) and (2) carry out a study to understand the implication of ctDCS stimulating the dentate nuclei (PhaseD) and lobules VII-IX (PhaseL) on the postural control of chronic stroke patients when they interacted with VBaT. Also, we investigated whether hemiplegic patients (with intact cerebellum) having Basal Ganglia (BG) infarction had any differential abilities to correct postural sway from those with no BG infarction (while shifting weight to the Affected side). Results...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - November 2, 2021 Category: Neuroscience Source Type: research

Transcranial Direct-Current Stimulation and Behavioral Training, a Promising Tool for a Tailor-Made Post-stroke Aphasia Rehabilitation: A Review
Aphasia is an acquired language disorder resulting from damage to portions of the brain which are responsible for language comprehension and formulation. This disorder can involve different levels of language processing with impairments in both oral and written comprehension and production. Over the last years, different rehabilitation and therapeutic interventions have been developed, especially non-invasive brain stimulation (NIBS) techniques. One of the most used NIBS techniques in aphasia rehabilitation is the Transcranial Direct-Current Stimulation (tDCS). It has been proven to be effective in promoting a successful r...
Source: Frontiers in Human Neuroscience - December 20, 2021 Category: Neuroscience Source Type: research

Atrial Fibrillation and Injected Aripiprazole: A Case Report
Conclusion In summary, although it is not possible to exclude confounding factors, the timing and dose-dependent effect of aripiprazole administration in our patient suggests an association between an initial intramuscular injection of long-acting aripiprazole and new onset of AF. This observation calls for clinical vigilance, not only in patients with additional risk factors for stroke but also in younger patients who might have predisposing factors for arrhythmias. References CPS (Canadian Pharmacists Association). Available at: http://www.e-therapeutics.ca. Accessed January 1, 2017. Polcwiartek C, Sneider B, Graff C,...
Source: Innovations in Clinical Neuroscience - May 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Case Report Current Issue adverse effects aripiprazole atrial fibrillation schizoaffective disorder Source Type: research

Functional MRI of Letter Cancellation Task Performance in Older Adults
Conclusion The present work is the first to identify neural correlates of the LCT using fMRI and tablet technology in a healthy aging population. Across all ages, the activation was found to be bilateral, including in the cerebellum, superior temporal lobe, precentral gyrus, frontal gyrus, and various occipital and parietal areas. With increasing age, performance generally decreased and brain activity was reduced in the supplementary motor area, middle and inferior frontal gyrus, middle occipital gyrus, putamen and cerebellum. Better LCT performance was correlated with increased activity in the middle frontal gyrus, and r...
Source: Frontiers in Human Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

Editor ’ s Message: September –October 2016 Issue Highlights
Dear Colleagues: Welcome to the September-October 2016 issue of Innovations in Clinical Neuroscience (ICNS). As the official journal of the CNS Summit, the International Society for CNS Drug Development (ISCDD), and the International Society for CNS Clinical Trials and Methodology (ISCTM), an important part of our editorial mission is to accelerate and enhance of the development of cheaper, more effective treatments for our patients through technology, collaboration, and innovation—not just in neuroscience but in all disciplines of medicine and among all involved entities, including clinicians, researchers, and members o...
Source: Innovations in Clinical Neuroscience - October 9, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Drug Development Editor's Message: Issue Highlights Neurology Psychiatry Trial Methodology Amir H. Kalali CNS Summit Innovations in Clinical Neuroscience ISCDD ISCTM Source Type: research

Exploring Training Effect in 42 Human Subjects Using a Non-invasive Sensorimotor Rhythm Based Online BCI
Conclusion In this study, we analyzed a pooled dataset consisting of 42 subjects’ three BCI training sessions. The behavioral performance results showed that there was a significant increase of BCI PVC accuracy (p = 0.004) and a marginal significant improvement of ITR (p = 0.05) in the third training session compared to the first session. No other significant difference of behavioral measures such as group average abort rate or feedback duration was found across the training sessions. Further analysis on the group average R2 value indicated that there was a significant difference of the R2 value on the first traini...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders
AbstractNINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer ’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While theNINJ2 rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs38...
Source: Journal of Molecular Neuroscience - December 22, 2019 Category: Neuroscience Source Type: research

Valproic Acid: A New Candidate of Therapeutic Application for the Acute Central Nervous System Injuries.
Abstract Acute central nervous system (CNS) injuries, including stroke, traumatic brain injury (TBI), and spinal cord injury (SCI), are common causes of human disabilities and deaths, but the pathophysiology of these diseases is not fully elucidated and, thus, effective pharmacotherapies are still lacking. Valproic acid (VPA), an inhibitor of histone deacetylation, is mainly used to treat epilepsy and bipolar disorder with few complications. Recently, the neuroprotective effects of VPA have been demonstrated in several models of acute CNS injuries, such as stroke, TBI, and SCI. VPA protects the brain from injury p...
Source: Neurochemical Research - January 31, 2014 Category: Neuroscience Authors: Chen S, Wu H, Klebe D, Hong Y, Zhang J Tags: Neurochem Res Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

A Data-Driven Volitional EMG Extraction Algorithm During Functional Electrical Stimulation With Time Variant Parameters
Conclusions: All results showed that SICEEMDAN-LR is capable of extracting EMG during FES with time-variant parameters.
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - April 30, 2020 Category: Neuroscience Source Type: research

P 194. The EEG correlates of the TMS induced EMG silent period in humans
Application of magnetic or electrical stimulation to the motor cortex can result in a period of electromyography (EMG) silence in a tonically active peripheral muscle. This period of EMG silence is referred to as the silent period (SP). The duration of SP shows intersubject variability and reflects the integrity of the cortical and corticospinal pathways. A non-invasive technique for assessing the duration of SP is the combination of Transcranial Magnetic Stimulation (TMS) with EMG. Utilizing TMS-EMG, several studies have reported on the shortening or lengthening of SP in neuropsychiatric disorders such as schizophrenia, b...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: F. Farzan, M.S. Barr, S. Hoppenbrouwers, P.B. Fitzgerald, R. Chen, A. Pascual-Leone, Z.J. Daskalakis Tags: Society Proceedings Source Type: research