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Specialty: Drugs & Pharmacology

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Total 5519 results found since Jan 2013.

Brain Drug Delivery Systems for the Stroke Intervention and Recovery.
CONCLUSION: Combined with new drug targets in the treatment of stroke, BDDS will provide more effective therapeutics for stroke intervention and recovery. PMID: 27784243 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - October 24, 2016 Category: Drugs & Pharmacology Authors: Luo T, Wang J, Hao S, Guo T, Ren P, Cheng Z, Gao F, Gong Y, Wang B Tags: Curr Pharm Des Source Type: research

Oral antiplatelet and anticoagulant agents in the prevention and management of ischemic stroke.
Abstract Despite numerous advances over the last 50 years, stroke continues to be a leading cause of death and disability worldwide. The treatment and prevention of stroke has undergone extensive study, and significant advances in medical management have occurred within the past decade principally with the development of new classes of orally active anticoagulant drugs. Here we review these recent breakthroughs and the varying roles of anticoagulants and antiplatelet agents in the prevention and management of different ischemic stroke subtypes, as well as describe the benefits and ongoing challenges to incorporati...
Source: Current Pharmaceutical Design - December 20, 2016 Category: Drugs & Pharmacology Authors: Shrestha S, Coy S, Bekelis K Tags: Curr Pharm Des Source Type: research

The cost savings of newer oral anticoagulants in atrial fibrillation-related stroke prevention 
.
CONCLUSION: AF stroke patients incurred higher total direct costs compared to non-AF cases. However, more cost savings were evident with NOACs, due to more strokes being prevented through the use of NOACs compared to warfarin.
. PMID: 28025962 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - December 28, 2016 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats.
In conclusion, Met improved the arterial baroreflex function, and then enhancing cholinergic anti-inflammatory pathway in an α7nAChR-dependent manner, thereby effectively prevent ischemic induced brain injury and delayed stroke onset in SHRSP. PMID: 28132912 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - January 25, 2017 Category: Drugs & Pharmacology Authors: Guo JM, Zhang L, Niu XC, Shu H, Wang L, Su DF, Zhang Y, Liu AJ, Zhu DQ, Xu JJ Tags: Eur J Pharmacol Source Type: research

Inhibition of TRPV1 confers neuroprotection, reduces TNF ‐α and increases Il‐10 in a rat stroke model
This article is protected by copyright. All rights reserved.
Source: Fundamental and Clinical Pharmacology - January 31, 2017 Category: Drugs & Pharmacology Authors: Elham Hakimizadeh, Ali Shamsizadeh, Ali Roohbakhsh, Mohammad Kazemi Arababadi, Mohammad Reza Hajizadeh, Mehdi Shariati, Mohammad Reza Rahmani, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Patient preferences regarding atrial fibrillation stroke prophylaxis in patients at potential risk of atrial fibrillation
Conclusions Reducing stroke risk and limiting ICH risk were the most important medication factors to participants. High inter-participant preference variability suggests the importance of including the patient in decision-making when selecting AF stroke prophylaxis.
Source: International Journal of Clinical Pharmacy - March 8, 2017 Category: Drugs & Pharmacology Source Type: research

Inhibition of transient receptor potential vanilloid ‐1 confers neuroprotection, reduces tumor necrosis factor‐alpha, and increases IL‐10 in a rat stroke model
In this study, the effects of TRPV1 agonist (capsaicin) and antagonist (AMG9810) on cerebral ischemia were investigated. Forty male Wistar rats were assigned to the following experimental groups: sham, vehicle) ischemic), AMG9810 (selective TRPV1 antagonist, 0.5 mg/kg; 3 h after stroke), and capsaicin (1 mg/kg; 3 h after stroke). Stroke was induced by permanent middle cerebral artery occlusion and neurological deficits were evaluated 1, 3, and 7 days after stroke. Then, infarct volume, brain edema, body temperature, mRNA expression of TRPV1, and serum concentrations of tumor necrosis factor‐alpha (TNF‐α) and IL‐10 w...
Source: Fundamental and Clinical Pharmacology - March 23, 2017 Category: Drugs & Pharmacology Authors: Elham Hakimizadeh, Ali Shamsizadeh, Ali Roohbakhsh, Mohammad Kazemi Arababadi, Mohammad R. Hajizadeh, Mehdi Shariati, Mohammad R. Rahmani, Mohammad Allahtavakoli Tags: Original Article Source Type: research

Previously undiagnosed risk factors and medication nonadherence are prevalent in young adults with first ‐ever stroke
ConclusionsPreviously undiagnosed hypertension and nonadherence to treatment of hypertension and diabetes were more prevalent in young adult patients with first‐ever stroke in Taiwan. Interventions targeting young people to promote early detection and adequate control of VRFs should be encouraged.
Source: Pharmacoepidemiology and Drug Safety - July 1, 2017 Category: Drugs & Pharmacology Authors: Sheng ‐Feng Sung, Edward Chia‐Cheng Lai, Darren Philbert Wu, Cheng‐Yang Hsieh Tags: ORIGINAL REPORT Source Type: research

The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion.
Abstract Exercise preconditioning has been shown to be effective in improving behavioral and neuropathological indices after cerebral ischemia. We evaluated the effect of exercise preconditioning, 17β-estradiol, and their combination on stroke outcome using an experimental model of stroke in ovariectomized (OVX) mice. OVX mice were randomly assigned to four groups as follows: control (stroke), exercise (exercise and stroke), estradiol (17β-estradiol and stroke), and exercise+estradiol (exercise and 17β-estradiol and stroke). Exercise preconditioning was performed on a treadmill five days per week, 40 min/day, a...
Source: Canadian Journal of Physiology and Pharmacology - September 5, 2017 Category: Drugs & Pharmacology Authors: Naderi S, Alimohammadi R, Hakimizadeh E, Roohbakhsh A, Shamsizadeh A, Allahtavakoli M Tags: Can J Physiol Pharmacol Source Type: research

Animal models of ischaemic stroke and characterisation of the ischaemic penumbra.
Abstract Over the past forty years, animal models of focal cerebral ischaemia have allowed us to identify the critical cerebral blood flow thresholds responsible for irreversible cell death, electrical failure, inhibition of protein synthesis, energy depletion and thereby the lifespan of the potentially salvageable penumbra. They have allowed us to understand the intricate biochemical and molecular mechanisms within the 'ischaemic cascade' that initiate cell death in the first minutes, hours and days following stroke. Models of permanent, transient middle cerebral artery occlusion and embolic stroke have been deve...
Source: Neuropharmacology - September 16, 2017 Category: Drugs & Pharmacology Authors: McCabe C, Arroja MM, Reid E, Macrae IM Tags: Neuropharmacology Source Type: research

Research on the nutrition and cognition of high-risk stroke groups in community and the relevant factors.
CONCLUSIONS: MNA-SF can be used for the nutritional screening of high-risk stroke groups in community. For the high-risk stroke groups in community, the rational nutritional diet should be publicized, blood sugar should be controlled in a scientific manner and physical exercise should be moderately increased. PMID: 29243783 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Dl-3-n-Butylphthalide (NBP) ：A Promising Therapeutic Agent for Ischemic Stroke.
Dl-3-n-Butylphthalide (NBP)：A Promising Therapeutic Agent for Ischemic Stroke. CNS Neurol Disord Drug Targets. 2018 Jun 12;: Authors: Wang S, Ma F, Huang LJ, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL, Peng Y Abstract Stroke is a leading cause of morbidity and mortality in both developed and developing countries all over the world. The only drug for ischemic stroke approved by FDA is recombinant tissue plasminogen activator (rtPA). However, only 2-5% stroke patients receive rtPAs treatment due to its strict therapeutic time window. As ischemic stroke is a complex disease involving in multiple mecha...
Source: CNS and Neurological Disorders Drug Targets - June 12, 2018 Category: Drugs & Pharmacology Authors: Wang S, Ma F, Huang LJ, Zhang Y, Peng YC, Xing CH, Feng YP, Wang XL, Peng Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Post-stroke losartan and captopril treatments arrest hemorrhagic expansion in SHRsp without lowering blood pressure.
Abstract We assessed the ability of poststroke losartan and captopril treatment to attenuate hematoma expansion and plasma extravasation after intracerebral hemorrhagic stroke in Kyoto-Wistar stroke-prone hypertensive rats (SHRsp). Cerebrum volume, herniation and surface areas exhibiting new and old hemorrhages and albumin extravasation were measured prior to and after stroke and following 30 and 60 days of post-stroke losartan or captopril treatment in Evans Blue dye perfused brains. Lesion morphology was studied in serial sections. Losartan or captopril treatment initiated at stroke prevented death for 60 da...
Source: Vascular Pharmacology - August 13, 2018 Category: Drugs & Pharmacology Authors: Smeda JS, Watson D, Stuckless J, Neghandi A Tags: Vascul Pharmacol Source Type: research

Title: The effect of pyruvate on the development and progression of post-stroke depression: A new therapeutic approach.
Abstract Post-stroke depression (PSD) is a common and serious complication following stroke. Both stroke and depression have independently been associated with pathologically elevated glutamate levels in the brain's extra-cerebral fluid (ECF). Here we evaluate an alternative therapeutic approach to PSD with pyruvate. Rats were randomly assigned into one of 3 groups: Middle Cerebral Artery Occlusion (MCAO) plus pyruvate treatment, MCAO plus placebo treatment, and sham operated rats. Post-MCAO depressive and anxiety-like behavior was assessed, along with neurological status, brain infarct zone, brain edema, blood br...
Source: Neuropharmacology - May 29, 2019 Category: Drugs & Pharmacology Authors: Frank D, Kuts R, Tsenter P, Gruenbaum BF, Grinshpun Y, Zvenigorodsky V, Shelef I, Natanel D, Brotfain E, Zlotnik A, Boyko M Tags: Neuropharmacology Source Type: research