Involvement of arterial baroreflex and nicotinic acetylcholine receptor α7 subunit pathway in the protection of metformin against stroke in stroke-prone spontaneously hypertensive rats.

In conclusion, Met improved the arterial baroreflex function, and then enhancing cholinergic anti-inflammatory pathway in an α7nAChR-dependent manner, thereby effectively prevent ischemic induced brain injury and delayed stroke onset in SHRSP.
PMID: 28132912 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - January 25, 2017 Category: Drugs & Pharmacology Authors: Guo JM, Zhang L, Niu XC, Shu H, Wang L, Su DF, Zhang Y, Liu AJ, Zhu DQ, Xu JJ Tags: Eur J Pharmacol Source Type: research