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Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Endovascular treatment for isolated posterior cerebral artery occlusion stroke in the MR CLEAN registry
Conclusions EVT should be considered in selected patients with AIS with an isolated PCA occlusion, presenting with moderate–severe neurological deficits, as EVT was technically feasible in most of our patients and about half had good clinical outcome. In case of lower NIHSS score, a more conservative approach seems warranted, since periprocedural complications are not uncommon. Nonetheless, EVT seems reasonably safe considering the absence of sICH in our study.
Source: Journal of NeuroInterventional Surgery - March 14, 2023 Category: Neurosurgery Authors: Brouwer, J., Ergezen, S., Mulder, M. J. H. L., Lycklama a Nijeholt, G. J., van Es, A. C. G. M., van der Lugt, A., Dippel, D. W. J., Majoie, C. B. L. M., Roos, Y. B. W. E. M., Coutinho, J. M., Emmer, B. J., on behalf of the MR CLEAN Registry investigators, Tags: Ischemic stroke Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Etiology of Large Vessel Occlusion Posterior Circulation Stroke: Results of the MR CLEAN Registry
CONCLUSIONS: Unlike the anterior circulation, most frequent cause in our posterior large vessel occlusion stroke cohort is LAA followed by cardioembolism, dissection, and ESUS. Patients with cardioembolism and ESUS have a better prognosis for functional outcome after endovascular thrombectomy than patients with LAA.PMID:35543130 | DOI:10.1161/STROKEAHA.121.038054
Source: Atherosclerosis - May 11, 2022 Category: Cardiology Authors: F A V Anne Pirson Nikki Boodt Josje Brouwer Agnetha A E Bruggeman Wouter H Hinsenveld Julie Staals Wim H van Zwam Christiaan van der Leij Rutger J B Brans Charles B L M Majoie Diederik W J Dippel Aad van der Lugt Wouter J Schonewille Robert J van Oostenbr Source Type: research

Influence of Onset to Imaging Time on Radiological Thrombus Characteristics in Acute Ischemic Stroke
Conclusion: In our population of acute ischemic stroke patients, we found no clear association between onset-to-imaging time and radiological thrombus characteristics. This suggests that elapsed time from stroke onset plays a limited role in the interpretation of radiological thrombus characteristics and their effect on treatment results, at least in the early time window.
Source: Frontiers in Neurology - June 18, 2021 Category: Neurology Source Type: research

Wake-Up Stroke versus Stroke with Known Onset Time: Clinical and Multimodality CT Imaging Characteristics
Conclusions: There are only minor differences between clinical and imaging characteristics of WUS patients and patients who arrive in the hospital within the time criteria for intravenous or endovascular treatment. Therefore, CT imaging may help to identify WUS patients who would benefit from treatment and rule out those patients with severe ischemia and poor collaterals.Cerebrovasc Dis 2018;45:236 –244
Source: Cerebrovascular Diseases - May 17, 2018 Category: Neurology Source Type: research

Circle of Willis variations in migraine patients with ischemic stroke
ConclusionWe found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.
Source: Brain and Behavior - February 16, 2019 Category: Neurology Authors: Arend M. Hamming, Marianne A. A. van Walderveen, Inge A. Mulder, Irene C. van der Schaaf, L. Jaap Kappelle, Birgitta K. Velthuis, Michel D. Ferrari, Gisela M. Terwindt, Marieke C. Visser, Wouter Schonewille, Ale Algra, Marieke J. H. Wermer, On Tags: ORIGINAL RESEARCH Source Type: research

Value of Quantitative Collateral Scoring on CT Angiography in Patients with Acute Ischemic Stroke ADULT BRAIN
CONCLUSIONS: Automated quantitative collateral scoring in patients with acute ischemic stroke is a reliable and user-independent measure of the collateral capacity on baseline CTA and has the potential to augment the triage of patients with acute stroke for endovascular therapy.
Source: American Journal of Neuroradiology - June 13, 2018 Category: Radiology Authors: Boers, A. M. M., Sales Barros, R., Jansen, I. G. H., Berkhemer, O. A., Beenen, L. F. M., Menon, B. K., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Slump, C. H., Majoie, C. B. L. M., Marquering, H. A. Tags: ADULT BRAIN Source Type: research

Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography
ConclusionData from CT imaging significantly improved the discriminatory performance and reclassification in predicting ischemic stroke recurrence beyond a model incorporating clinical risk factors only.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Peripheral Artery Disease in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy; Results From the MR CLEAN Registry
Conclusion: In the absence of an association between the presence of PAD and collateral scores or outcomes after EVT, it may be questioned whether PAD leads to RIPC in patients with acute ischemic stroke due to large vessel occlusion.
Source: Frontiers in Neurology - October 6, 2020 Category: Neurology Source Type: research

Expediting workflow in the acute stroke pathway for endovascular thrombectomy in the northern Netherlands: a simulation model
Conclusions In our region, the proposed workflow improvements might reduce time to treatment by about 1 hour and increase the number of patients regaining functional independence by 6%. Simulation modelling is useful for assessing the potential effects of interventions aimed at reducing time from onset to EVT.
Source: BMJ Open - April 6, 2022 Category: General Medicine Authors: Maas, W. J., Lahr, M. M. H., Uyttenboogaart, M., Buskens, E., van der Zee, D.-J., On behalf of CONTRAST investigators Tags: Open access, Neurology Source Type: research

Accuracy of CT Angiography for Differentiating Pseudo-Occlusion from True Occlusion or High-Grade Stenosis of the Extracranial ICA in Acute Ischemic Stroke: A Retrospective MR CLEAN Substudy INTERVENTIONAL
CONCLUSIONS: On CTA, extracranial ICA pseudo-occlusions can be differentiated from true carotid occlusions.
Source: American Journal of Neuroradiology - May 15, 2018 Category: Radiology Authors: Kappelhof, M., Marquering, H. A., Berkhemer, O. A., Borst, J., van der Lugt, A., van Zwam, W. H., Vos, J. A., Lycklama a Nijeholt, G., Majoie, C. B. L. M., Emmer, B. J., on behalf of the MR CLEAN Investigators Tags: INTERVENTIONAL Source Type: research

Radiology workload in clinical implementation of thrombectomy for acute ischemic stroke: experience from The Netherlands
ConclusionOur study estimated the number of stroke patients undergoing CTA for suspected LVO and those eligible for thrombectomy in relation to the population. Numbers were essentially the same throughout the week, and during office and on-call hours. Our data can be used to make adequate staffing plans.
Source: Neuroradiology - April 4, 2020 Category: Radiology Source Type: research

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