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Procedure: Perfusion

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Teleradiology-based stroke network in Western and Southern Transdanubia in Hungary
CONCLUSION: With the help of the dedicated teleradiology stroke network, we want to optimize the stroke care in the region: on the one hand, patients who are likely to benefit from thrombectomy should not be left unattended, on the other, the health care system should not be burdened with cases, when intervention is not recommended having the complete clinical data accessed. Orv Hetil. 2021; 162(17): 668-675.PMID:33838025 | DOI:10.1556/650.2021.32097
Source: Orvosi Hetilap - April 10, 2021 Category: General Medicine Authors: P éter Bogner Zolt án Chadaide G ábor Lenzsér Istv án Kondákor G ábor Tárkányi S ándor Szukits Eszter Juh ász Andor Sebesty én J ózsef Janszky Andr ás Büki Tam ás Dóczi L ászló Szapáry Source Type: research

Direct and Indirect Cost Burden of Stroke Mimics Post Intravenous Tissue Plasminogen Activator (IV-tPA): A Single Center Study (P3.103)
CONCLUSIONS:This study reveals that stroke mimics can have significant cost burden on health care system; mainly from the cost of IV-tPA and higher level of care. An urgent MR with selected sequences and perfusion imaging in certain patient population can be helpful to exclude patients with stroke mimics, avoid extra cost, and prevent unnecessary distress to the patient and family.Disclosure: Dr. Goyal has nothing to disclose. Dr. Male has nothing to disclose. Dr. Al Wafai has nothing to disclose. Dr. Zand has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Goyal, N., Male, S., Al Wafai, A., Zand, R. Tags: Cerebrovascular Disease and Interventional Neurology: t-PA Source Type: research

E-006 Extremes of body mass indices and thrombectomy outcomes: a new paradox in acute stroke treatment?
Conclusion Extremes of BMI were associated with better clinical outcomes with a "reverse U-shaped relationship" in patients with large vessel occlusions of the anterior circulation undergoing endovascular treatment, as the best clinical outcomes were observed in the UW and MO. This paradox differs from the previously described "obesity paradox," in which OW and mildly Ob typically have better outcomes than the NW, UW, and MO.1,2 The cause of and implications for these findings in acute stroke treatment is unclear. While these results may be secondary to patient selection bias, additional potential mechanisms include possib...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Lavie, J., Bennett, G., Arndt, S., Albar, A., Wojcik, K., Milburn, J., Vidal, G. Tags: Electronic Poster Abstracts Source Type: research

Thrombectomy in stroke of unknown onset, wake up stroke and late presentations: Australian experience from 2 comprehensive stroke centres
This study shows good ‘real world’ outcomes, comparable to published RCTs, in patients with unknown-onset, or late presentation, stroke treated with EVT more than 6 h from stroke onset.
Source: Journal of Clinical Neuroscience - November 8, 2018 Category: Neuroscience Source Type: research

Monitoring synaptic loss in a rat model of stroke: a PET imaging study with 18FSynVesT-2, radiotracer for the synaptic vesicle protein 2A (SV2A)
Conclusions: Using [18F]SynVesT-2 and PET imaging, we successfully detected synapse loss in rat MCAO model and tracked disease progression via lesion quantification. Synapse loss is mainly in hippocampus, thalamus, and neocortex, rather than cerebellum. Furthermore, most significant loss of synapses was observed to occur during the first week post reperfusion. Our results showed that the quantification of synaptic density by SV2A PET may provide an objective measure of disease progression and a primary endpoint to evaluate treatment efficacy of novel therapeutics for stroke in clinical trials. References: Bunevicius et al....
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Lyu, X., Toyonaga, T., Deng, G., Huang, Y., Carson, R., Zhou, J., Cai, Z. Tags: Basic Science - Synaptic activity and other mechanisms Source Type: research

Intraoperative hypotension and perioperative acute ischemic stroke in patients having major elective non-cardiovascular non-neurological surgery
ConclusionOur analysis suggests that when MAP is less than 60  mmHg for more than 20 min, there is increased odds of acute ischemic stroke. Further studies are needed to determine what MAP should be targeted during surgery to optimize cerebral perfusion and limit ischemic stroke risk.
Source: Journal of Anesthesia - February 9, 2021 Category: Anesthesiology Source Type: research

Current perspectives on neuroimaging techniques used to identify stroke mimics in clinical practice
Expert Rev Neurother. 2021 Mar 31. doi: 10.1080/14737175.2021.1911650. Online ahead of print.ABSTRACTINTRODUCTION: Urgent clinical assessment and brain imaging is essential for differentiating stroke mimics from stroke and to avoid unnecessary initiation of reperfusion and other therapies in stroke mimic patients.AREAS COVERED: In this article, the authors will review acute stroke imaging and then the imaging patterns of the most common stroke mimics. The authors have focused our review on brain CT scan, and more specifically CT perfusion, as this is the most commonly available and emerging tool in emergency settings. The ...
Source: Expert Review of Neurotherapeutics - March 31, 2021 Category: Neurology Authors: Shadi El-Wahsh Sophie Dunkerton Timothy Ang Hugh Stephen Winters Candice Delcourt Source Type: research