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Drug: Acetazolamide
Procedure: SPECT

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Total 16 results found since Jan 2013.

Obstructive carotid and/or intracranial artery disease rarely affects the incidence of haemodynamic ischaemic stroke during cardiac surgery: a study on brain perfusion single-photon emission computed tomography with acetazolamide ADULT CARDIAC
CONCLUSIONS It is unusual for CIAD to affect the incidence of haemodynamic ischaemic stroke during cardiac surgery. Brain perfusion SPECT with acetazolamide is effective for narrowing down patients at high risk of ischaemic stroke during cardiac surgery. Meanwhile, the application of brain perfusion single-photon emission tomography should be confined only to patients with obstructive CIAD because it is an expensive examination tool.
Source: European Journal of Cardio-Thoracic Surgery - October 16, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Imasaka, K.-i., Yasaka, M., Tayama, E., Tomita, Y. Tags: Cardiac - other ADULT CARDIAC Source Type: research

Correlation of Transcranial Doppler Breath Holding Test and Acetazolamide SPECT Scan for Anterior Circulation Steno-Occlusive Disease (P6.019)
Conclusions: There was a modest correlation between TCD-R and acetazolamide SPECT scan for anterior circulation steno-occlusive disease in our patient cohort. TCD-R demonstrated higher sensitivity for the detection of poor cerebrovascular reserve than acetazolamide SPECT. Further studies are needed to determine which study is more useful in the management of this high-risk population. Disclosure: Dr. Parikh has nothing to disclose. Dr. Cerejo has nothing to disclose. Dr. Raber has nothing to disclose. Dr. Thompson has nothing to disclose. Dr. Uchino has nothing to disclose. Dr. Katzan has received personal compensation f...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Parikh, P., Cerejo, R., Raber, L., Thompson, N., Uchino, K., Katzan, I. Tags: Ischemic Stroke Diagnosis Source Type: research

Coronary artery bypass surgery in patients with chronic brain hypoperfusion.
CONCLUSIONS: CABG can be performed at an acceptable risk in patients with brain hypoperfusion. However, these patients suffered high stroke incidence during the follow-up. It is therefore, important to identify those patients preoperatively to plan and implement an appropriate treatment regime. PMID: 29616518 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - April 3, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Imura H, Maruyama Y, Takahashi K, Nishina D, Nitta T Tags: J Cardiovasc Surg (Torino) Source Type: research

Assessment of cerebral blood perfusion changes after neurorehabilitation therapy in patients with middle cerebral artery infarction: An acetazolamide ‐challenged SPECT study
Abstract Stroke is a leading cause of death and disability worldwide. Although neuroimaging has been used to examine brain changes related to recovery from stroke, cerebral perfusion changes after rehabilitation have yet to be elucidated. The aim of this study was to evaluate the regional cerebral blood flow (rCBF) changes and their associations with gross motor functions after neurorehabilitation therapy in stroke patients. A total of 7 patients with middle cerebral artery (MCA) infarction received conventional neurorehabilitation therapy twice per day for 4‐6 weeks on admission. Brain perfusion images were acquired bef...
Source: International Journal of Imaging Systems and Technology - November 11, 2017 Category: Radiology Authors: Kyung ‐Sool Jang, Jooyeon J. Im, Yong‐An Chung, Sung‐Woo Chung, Hyeonseok S. Jeong, Min‐Wook Kim Tags: RESEARCH ARTICLE Source Type: research

Improvement in cerebral hemodynamic parameters and outcomes after superficial temporal artery-middle cerebral artery bypass in patients with severe stenoocclusive disease of the intracranial internal carotid or middle cerebral arteries.
CONCLUSIONS STA-MCA bypass surgery in carefully selected patients with symptomatic severe intracranial stenoocclusive disease of the intracranial ICA or MCA results in significant improvement in hemodynamic parameters and reduction in stroke recurrence. PMID: 26023999 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 29, 2015 Category: Neurosurgery Authors: Low SW, Teo K, Lwin S, Yeo LL, Paliwal PR, Ahmad A, Sinha AK, Teoh HL, Wong LY, Chong VF, Seet RC, Chan BP, Yeo TT, Chou N, Sharma VK Tags: J Neurosurg Source Type: research

Cerebral hemodynamic benefits after carotid artery stenting in patients with near occlusion
Conclusions: Before CAS, patients with NO were more hemodynamically compromised than those with severe stenosis without NO. After CAS, significant cerebral hemodynamic improvement and normalization occurred long-term. Thus, from a hemodynamic perspective, CAS was effective in patients with NO.
Source: Journal of Vascular Surgery - July 26, 2013 Category: Surgery Authors: Fumiaki Oka, Hideyuki Ishihara, Shoichi Kato, Takayuki Oku, Akiko Yamane, Ichiro Kunitugu, Michiyasu Suzuki Tags: Clinical research studies Source Type: research

123I-IMP-SPECT in a Patient with Cerebral Proliferative Angiopathy: A Case Report
We describe cerebral perfusion abnormalities in a patient with CPA by using N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123I-IMP-SPECT) and perfusion-weighted magnetic resonance imaging. The patient, a 13-year-old boy, had reversible focal neurological deficits unrelated to cerebral hemorrhage. 123I-IMP-SPECT at resting state showed preserved uptake within the vascular lesion, yet lower uptake in the area adjacent to the lesion. In addition, acetazolamide-stressed 123I-IMP-SPECT exhibited severely impaired cerebrovascular reactivity over the affected hemisphere, suggesting that his foca...
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Tomomi Kimiwada, Toshiaki Hayashi, Reizo Shirane, Teiji Tominaga Tags: Case Reports Source Type: research

Arterial Spin Labeling Perfusion Magnetic Resonance Image with Dual Postlabeling Delay: A Correlative Study with Acetazolamide Loading I-Iodoamphetamine Single-Photon Emission Computed Tomography
Perfusion magnetic resonance image with arterial spin labeling (ASL) provides a completely noninvasive measurement of cerebral blood flow (CBF). However, arterial transient times can have a marked effect on the ASL signal. For example, a single postlabeling delay (PLD) of 1.5 seconds underestimates the slowly streaming collateral pathways that maintain the cerebrovascular reserve (CVR). To overcome this limitation, we developed a dual PLD method.
Source: Journal of Stroke and Cerebrovascular Diseases - September 16, 2015 Category: Neurology Authors: Sei Haga, Takato Morioka, Takafumi Shimogawa, Tomoaki Akiyama, Kei Murao, Yuka Kanazawa, Tetsuro Sayama, Shuji Arakawa Source Type: research

Hemodynamic Significance of Internal Carotid or Middle Cerebral Artery Stenosis Detected on Magnetic Resonance Angiography.
CONCLUSION: A considerable proportion of ICA-MCA stenosis detected on MRA does not cause CVR impairment despite a fair correlation between them. Thus, hemodynamic state needs to be assessed for evaluating significance of stenosis, particularly in asymptomatic patients. PMID: 26446655 [PubMed - in process]
Source: Yonsei Medical Journal - October 9, 2015 Category: Universities & Medical Training Authors: Seo HJ, Pagsisihan JR, Paeng JC, Choi SH, Cheon GJ, Chung JK, Lee DS, Kang KW Tags: Yonsei Med J Source Type: research

Near infrared spectroscopy - investigations in neurovascular diseases.
This study showed increased LFOs amplitude only in FHM patients with co-existing common type of migraine, but not in patients with pure FHM phenotype. This suggests that the sensitivity to NO resides within the common migraine phenotypes rather than the FHM phenotype. Stimulation of the sphenopalatine ganglion (SPG) may lead to parasympathetic outflow and cause pain in cluster headache (CH). The fifth study therefore investigated pain and autonomic symptoms in relation to high or low SPG frequency stimulation in chronic CH patients. Cortical changes in oxygenated hemoglobin (HbO) were also recorded with NIRS and showed a m...
Source: Danish Medical Journal - December 12, 2015 Category: Journals (General) Tags: Dan Med J Source Type: research

Assessment of Hemodynamic Compromise Using Computed Tomography Perfusion in Combination with 123I-IMP Single-Photon Emission Computed Tomography without Acetazolamide Challenge Test
In this study, we investigated whether CT perfusion in combination with resting state 123I-IMP SPECT could be used instead of the acetazolamide challenge test to evaluate hemodynamic compromise in patients with atherosclerotic occlusive disease.
Source: Journal of Stroke and Cerebrovascular Diseases - December 5, 2016 Category: Neurology Authors: Atsumu Hashimoto, Takeshi Mikami, Katsuya Komatsu, Shouhei Noshiro, Tohru Hirano, Masahiko Wanibuchi, Nobuhiro Mikuni Source Type: research

Progressive Cerebral Ischemia and Intracerebral Hemorrhage after Indirect Revascularization for a Patient with Cerebral Proliferative Angiopathy
We previously reported a patient with cerebral proliferative angiopathy (CPA) who showed cerebral ischemia in resting and acetazolamide-stressed N-isopropyl-p-[123I] iodoamphetamine single-photon emission computed tomography (123I-IMP-SPECT). At onset, the patient was treated conservatively. However, during the 2 years following initial onset, his hemiparesis and aphasia had gradually aggravated and his IQ scores were markedly decreased. MRI revealed progressive vascular proliferation and brain atrophy.
Source: Journal of Stroke and Cerebrovascular Diseases - February 6, 2019 Category: Neurology Authors: Tomomi Kimiwada, Toshiaki Hayashi, Misaki Takahashi, Reizo Shirane, Teiji Tominaga Source Type: research

Superficial temporal artery-middle cerebral artery anastomosis patency correlates with cerebrovascular reserve in adult moyamoya syndrome patients.
CONCLUSION: Our data suggest that improvement in cerebral perfusion and CVR depends on flow in the STA-MCA anastomosis in patients with Moyamoya syndrome. Systematic long-term follow-up of anastomosis flow, brain perfusion and CVR improves quantification of the benefit of STA-MCA anastomosis in terms of disease progression. PMID: 31185229 [PubMed - as supplied by publisher]
Source: Neuro-Chirurgie - June 7, 2019 Category: Neurosurgery Authors: Aboukais R, Verbraeken B, Leclerc X, Gautier C, Henon H, Vermandel M, Menovsky T, Lejeune JP Tags: Neurochirurgie Source Type: research

Quantitative evaluation using single-photon emission computed tomography with acetazolamide is reliable for preoperative evaluation before cardiac surgery in severe carotid intracranial artery stenotic and/or occlusive disease: a case report
Severe carotid and intracranial artery stenosis disease (CIAD) is major risk for perioperative stroke in coronary artery bypass grafting. Then, preoperative risk assessment is quite important.
Source: Journal of Cardiothoracic Surgery - July 23, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Eiki Tayama, Ryusuke Mori, Tomohiro Ueda, Ken-ichi Imasaka, Yukihiro Tomita and Shigeki Morita Tags: Case report Source Type: research

Detection of impaired cerebrovascular reactivity in patients with chronic cerebral ischemia using whole-brain 7T MRA
We examined whether whole-brain magnetic resonance angiography (MRA) at 7T could non-invasively detect impaired CVR in patients with chronic cerebral ischemia by demonstrating the leptomeningeal collaterals (LMCs).
Source: Journal of Stroke and Cerebrovascular Diseases - August 15, 2020 Category: Neurology Authors: Ikuko Uwano, Hiroyuki Kameda, Taisuke Harada, Masakazu Kobayashi, Wataru Yanagihara, Kengo Setta, Kuniaki Ogasawara, Kunihiro Yoshioka, Fumio Yamashita, Futoshi Mori, Tsuyoshi Matsuda, Makoto Sasaki Source Type: research