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Total 153 results found since Jan 2013.

Cancer in Young Adults With Ischemic Stroke Clinical Sciences
Conclusions— Cancer, and especially active cancer and no other apparent cause for stroke, is associated with unfavorable survival among young stroke patients.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Aarnio, K., Joensuu, H., Haapaniemi, E., Melkas, S., Kaste, M., Tatlisumak, T., Putaala, J. Tags: Acute Cerebral Infarction, Risk Factors for Stroke, Stroke in Children and the Young Clinical Sciences Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Risk of Ischemic and Hemorrhagic Strokes in Occult and Manifest Cancers Clinical Sciences
Conclusions—Cancer, occult and manifest, is associated with increased risks for stroke. The increased risk is linked mainly to cancers related to smoking.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Klaus Kaae Andersen, Tom Skyhoȷ Olsen Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Cytosolic Receptor Melanoma Differentiation-Associated Protein 5 Mediates Preconditioning-Induced Neuroprotection Against Cerebral Ischemic Injury Brief Reports
Conclusions— Poly-ICLC preconditioning is mediated by melanoma differentiation–associated protein 5 and its adaptor molecule IFN-promoter stimulator 1. This is the first evidence that a cytosolic receptor can mediate neuroprotection, providing a new target for the development of therapeutic agents to protect the brain from ischemic injury.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Gesuete, R., Christensen, S. N., Bahjat, F. R., Packard, A. E. B., Stevens, S. L., Liu, M., Salazar, A. M., Stenzel-Poore, M. P. Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Brief Reports Source Type: research

Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity
We present an autopsy case of repetitive stroke due to tumor emboli, indistinguishable from thromboembolism with a hypercoagulable state in its clinical course. A 72-year-old man diagnosed with stage IVA oropharyngeal squamous cell carcinoma received chemoradiotherapy. Follow-up imaging revealed mediastinal lymph nodes and pulmonary metastasis. One year later, the patient experienced right arm weakness, and brain magnetic resonance imaging showed acute ischemic lesions in multiple vascular territories.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2017 Category: Neurology Authors: Junji Takasugi, Manabu Sakaguchi, Naoki Oyama, Yasufumi Gon, Yasukazu Terasaki, Tsutomu Sasaki, Susumu Nakahara, Kenji Ohshima, Yumiko Hori, Eiichi Morii, Hideki Mochizuki Tags: Case Studies Source Type: research

The relationship between malignant tumors and ischemic stroke: II. Chronology of diagnoses and treatment of strokes
Orv Hetil. 2022 Jan 9;163(2):43-51. doi: 10.1556/650.2022.32329. Print 2022 Jan 9.ABSTRACTÖsszefoglaló. A malignus daganatok és a stroke együttesen gyakran fordulnak elő a stroke tradicionális rizikófaktoraival (magas vérnyomás, hyperlipidaemia, cukorbetegség, elhízás, dohányzás) rendelkező betegekben. Az elmúlt évtized kutatási eredményei alátámasztották, hogy a rosszindulatú daganatban szenvedő betegekben szignifikánsan nagyobb a stroke kockázata. A malignus daganatokhoz társuló stroke a leggyakrabban a malignus daganat diagnózisát követő fél-egy év során jelentkezik. A kapcsolat a más...
Source: Orvosi Hetilap - January 9, 2022 Category: General Medicine Authors: N óra Hajnóczky D ániel Bereczki Source Type: research

Stroke death in patients receiving radiation for head and neck cancer in the modern era
ConclusionsWhile radiotherapy for head and neck cancer increases the hazard of stroke death, this is reduced in the modern era and remains a very small absolute risk.
Source: Frontiers in Oncology - June 15, 2023 Category: Cancer & Oncology Source Type: research

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Abstract Although over one-third of stroke patients may develop post-stroke cognitive impairment (PSCI), the mechanisms underlying PSCI remain unclear. We explored here, the involvement of post-stroke inflammasomes in long-term PSCI development, using a 45 min-middle cerebral artery occlusion (MCAO)/reperfusion-induced PSCI model. Immunohistological assessment on day 1, 3, and 7 was followed by cognitive function test 28 days post-stroke. Evaluation of inflammasome sensor gene expression in aged mouse brains showed dominant expression of absent in melanoma 2 (Aim2) in 6-, 12-, and 18-month-old mouse brains. AIM2 m...
Source: Brain, Behavior, and Immunity - March 18, 2020 Category: Neurology Authors: Kim H, Seo JS, Lee SY, Ha KT, Choi BT, Shin YI, Ju Yun Y, Shin HK Tags: Brain Behav Immun Source Type: research

Systematic analysis of brain and skull ischemic injury expression profiles reveals associations of the tumor immune microenvironment and cell death with ischemic stroke
ConclusionThis systematic analysis not only helps in the understanding of the changes in the gene expression profiles of both the brain and skull with ischemic injury but also reveals the association of the tumor immune microenvironment and cell death with ischemic stroke.
Source: Frontiers in Immunology - December 20, 2022 Category: Allergy & Immunology Source Type: research

AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke
CONCLUSION: Our findings indicated that inhibiting AIM2 preserved the BBB integrity after ischemic stroke, at least partially by modulating STAT3 activation and that AIM2 may be a promising therapeutic target for cerebral ischemic stroke.PMID:34156153 | DOI:10.1111/cns.13699
Source: CNS Neuroscience and Therapeutics - June 22, 2021 Category: Neuroscience Authors: Si-Yi Xu Hui-Jie Bian Shu Shu Sheng-Nan Xia Yue Gu Mei-Juan Zhang Yun Xu Xiang Cao Source Type: research

Squamous Cell Carcinoma of the Neck: An Unlikely Stroke Mimic
Stroke mimics are noncerebrovascular conditions that present with classical stroke symptoms. They account for up to 30% of stroke presentations in the emergency department (ED). Emergency physicians are faced with a diagnostic dilemma —rapid treatment of stroke, a leading cause or mortality and morbidity in the United States, or ruling out the ever-growing list of conditions that mimic strokes.
Source: The Journal of Emergency Medicine - October 14, 2021 Category: Emergency Medicine Authors: Vera Obinwanne, Laura Bauler, Dylan Bergeon, Timothy Trichler Source Type: research