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Nutrition: Antidoxidants
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Total 1078 results found since Jan 2013.
Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research
Pathogenesis of (smoking-related) non-communicable diseases —Evidence for a common underlying pathophysiological pattern
Non-communicable diseases, like diabetes, cardiovascular diseases, cancer, stroke, chronic obstructive pulmonary disease, osteoporosis, arthritis, Alzheimer’s disease and other more are a leading cause of death in almost all countries. Lifestyle factors, especially poor diet and tobacco consumption, are considered to be the most important influencing factors in the development of these diseases. The Western diet has been shown to cause a significant distortion of normal physiology, characterized by dysregulation of the sympathetic nervous system, renin-angiotensin aldosterone system, and immune system, as well as disrupt...
Source: Frontiers in Physiology - December 15, 2022 Category: Physiology Source Type: research
The role of Nrf2 in relieving cerebral ischemia-reperfusion injury
Curr Neuropharmacol. 2022 Nov 29. doi: 10.2174/1570159X21666221129100308. Online ahead of print.ABSTRACTIschemic stroke includes two related pathological damage processes: brain injury caused by primary ischemia and secondary ischemia reperfusion (I/R) injury. I/R injury has become a worldwide health problem. Unfortunately, there is still a lack of satisfactory drugs for ameliorating cerebral I/R damage. Nrf2 is a vital endogenous antioxidant protein, which combines with Keap1 to maintain a dormant state under physiological conditions. When pathological changes such as I/R occurs, Nrf2 dissociates from Keap1 and activates ...
Source: Current Neuropharmacology - December 1, 2022 Category: Drugs & Pharmacology Authors: Yu Sun Xu Yang Lijun Xu Mengxiao Jia Limeng Zhang Peng Li Pengfei Yang Source Type: research
Discovery of novel danshensu derivatives bearing pyrazolone moiety as potential anti-ischemic stroke agents with antioxidant activity
In this study, a series of novel danshensu derivatives bearing pyrazolone moieties with dual antioxidant effects were synthesized for the treatment of ischemic stroke. Most compounds exhibited considerable DPPH free radical scavenging ability and neuroprotective activity against H2O2-induced oxidative injury in PC12 neuronal cells, without cytotoxicity. Among these target compounds, Del03 displayed the strongest dose-dependent neuroprotective activity in vitro, directly downregulated intracellular ROS levels, and improved the oxidative stress parameters MDA, SOD, and LDH. Del03 also promoted Nrf2 translocation to the nucle...
Source: Bioorganic Chemistry - November 27, 2022 Category: Chemistry Authors: Yi Li Yunchun Luo Jing Wang Hao Shi Jun Liao Yan Wang Zhesheng Chen Liyan Xiong Chuan Zhang Tingfang Wang Source Type: research
Vitality ‐Enhanced Dual‐Modal Tracking System Reveals the Dynamic Fate of Mesenchymal Stem Cells for Stroke Therapy (Small 47/2022)
Stroke TherapyIn article number2203431, Xiaoling Gao, He Wang, Jun Chen, and co-workers engineer mesenchymal stem cells (MSCs) with near-infrared (NIR) and magnetic resonance (MR) dual-modal tracking nanoparticles via a bioorthogonal method. An antioxidant layer covered on the MSCs' surface enhances their vitality in a harsh stroke microenvironment. The vitality-enhanced MSCs remigrate from penumbra to the infarct core act just like firemen struggling with a fire to save lives.
Source: Small - November 25, 2022 Category: Nanotechnology Authors: Jianpei Xu,
Yuwen Zhang,
Yipu Liu,
Yang You,
Fengan Li,
Yu Chen,
Laozhi Xie,
Shiqiang Tong,
Songlei Zhou,
Kaifan Liang,
Yukun Huang,
Gan Jiang,
Qingxiang Song,
Ni Mei,
Fenfen Ma,
Xiaoling Gao,
He Wang,
Jun Chen Tags: Inside Back Cover Source Type: research
Dipyridamole ameliorates doxorubicin-induced cardiotoxicity
J Med Life. 2022 Sep;15(9):1184-1190. doi: 10.25122/jml-2021-0199.ABSTRACTDipyridamole is a platelet inhibitor with antithrombotic properties that can help prevent stroke recurrence. Twenty-eight male rats were divided randomly into four groups (7 rats in each group). Control group: rats received a natural diet and water. Normal saline group: rats received 0.9% normal saline for two weeks. Doxorubicin group (induced group): rats received 2.5 mg/kg three times a week for two weeks. Dipyridamole group (dipyridamole treated group): received dipyridamole (6 mg/kg/daily) orally for two weeks. Doxorubicin caused cardiotoxicity a...
Source: Journal of Medicine and Life - November 23, 2022 Category: General Medicine Authors: Esraa Alyasiry Ali Janabi Najah Hadi Source Type: research
Prevalence and influence of hypouricemia on cardiovascular diseases in patients with rheumatoid arthritis
ConclusionsHypouricemia may be a potential risk factor of CVDs in RA patients
Source: European Journal of Medical Research - November 21, 2022 Category: Research Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury
Neurochem Res. 2022 Nov 19. doi: 10.1007/s11064-022-03822-7. Online ahead of print.ABSTRACTFerroptosis is characterized by excessive accumulation of iron and lipid peroxides, which are involved in ischemia, reperfusion-induced organ injury, and stroke. Propofol, an anesthetic agent, has neuroprotective effects due to its potent antioxidant, anti-ischemic, and anti-inflammatory properties. However, the relationship between propofol and ferroptosis is still unclear. In the current study, we elucidated the role of ferroptosis in the neuroprotective effect of propofol in mouse brains subjected to cerebral ischemia reperfusion ...
Source: Neurochemical Research - November 19, 2022 Category: Neuroscience Authors: Gui-Bo Fan Yan Li Gao-Shuo Xu A-Yang Zhao Hong-Jiang Jin Si-Qi Sun Si-Hua Qi Source Type: research
