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Infectious Disease: Polio

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Total 35 results found since Jan 2013.

Viral diseases of the nervous system-Selected new and old viruses
Nervenarzt. 2023 Mar 21:1-8. doi: 10.1007/s00115-023-01452-0. Online ahead of print.ABSTRACTViral diseases of the nervous system are ancient and poliomyelitis was described in Egypt as early as 2000 BC. They can cause a wide range of neurological symptoms, such as meningitis, encephalitis, meningoencephalitis, Guillain-Barré-like syndrome and stroke, often leaving mild to severe residuals. Depending on the pathogen, the symptoms appear quickly within hours, or lead to increasing chronic symptoms within 1 week or months. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was newly identified in January...
Source: Herpes - March 21, 2023 Category: Infectious Diseases Authors: Uta Meyding-Lamad é Eva Maria Craemer Source Type: research

What is Ondine ’ s Curse?
Discussion Congenital central hypoventilation syndrome (CCHS) is an autosomal dominant with variable inheritance genetic disease caused by mutation in the Paired Like Homeobox B2 (PHOX2B) gene on chromosome 4. There are two other genes which may also cause CCHS. CCHS affects the chemoreceptor afferent ventilation pathways and is a neural crest migration problem of the autonomic nervous system. The incidence is unknown but a prevalence of 1 in 200,000 live births has been reported. Obviously it is a rarer phenomenon because of the general lethality of the syndrome. Patients usually present at birth or soon afterwards, but o...
Source: PediatricEducation.org - August 15, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Medical Comorbidities and Complications Associated with Poliomyelitis and Its Sequelae
Survivors of poliomyelitis may experience long-term sequelae that put them at increased risk for injury, pain, cardiovascular deconditioning, and functional decline. Osteoporotic fractures and entrapment neuropathies, in particular, may result in greater impairments in one ’s mobility and ability to perform activities of daily living. Dysphagia may necessitate the use of compensatory swallow strategies to minimize aspiration risk. Comorbid conditions, including hypertension, dyslipidemia, obesity, and stroke, are also very prevalent in this population. Risk factor m odification, including diet, exercise, and medication c...
Source: Physical Medicine and Rehabilitation Clinics of North America - May 19, 2021 Category: Rehabilitation Authors: Lauren T. Shapiro, Andrew L. Sherman Source Type: research

Acute Flaccid Myelitis: A Clinical Review
Semin Neurol DOI: 10.1055/s-0040-1705123Acute flaccid myelitis (AFM) is an emerging disorder primarily affecting children that is characterized by acute flaccid paralysis accompanied by abnormalities of the spinal cord gray matter on magnetic resonance imaging. In most cases, prodromal fever or respiratory symptoms occur, followed by acute-onset flaccid limb weakness. Respiratory, axial, bulbar, facial, and extraocular muscles may also be affected. The clinical manifestations have been described as “polio-like,” due to striking similarities to cases of poliomyelitis. The primary site of injury in AFM is the anterior ho...
Source: Seminars in Neurology - March 5, 2020 Category: Neurology Authors: Murphy, Olwen C. Pardo, Carlos A. Tags: Review Article Source Type: research

Assessment of exercise stroke volume and its prediction from oxygen pulse in Paralympic Athletes with locomotor impairments: cardiac long-term adaptations are possible.
The determinants of cardiac output (CO) during exercise, i.e., stroke volume (SV) and heart rate (HR), could differ in Paralympic athletes (PAthl) with spinal cord injury (SCI) with respect to PAthl with locomotor impairments caused by different health conditions (HC). The purposes of the present study were the comparisons of two groups of PAthl, one with SCI and one with either amputation (AMP) or post poliomyelitis syndrome (PM), assessing the: (1) peak cardiorespiratory responses and determinants (SV and HR) of CO during maximal and submaximal arm cranking exercise (ACE), respectively; (2) correlations between peak oxyg...
Source: Frontiers in Physiology - January 7, 2020 Category: Physiology Source Type: research

Preface
Growing up in rural South India, I witnessed the lifelong effects of polio in my great-uncle and the effects of disability in my grandfather after he suffered a stroke. There were minimal access to health care of any type and no access to medical rehabilitation.
Source: Physical Medicine and Rehabilitation Clinics of North America - September 26, 2019 Category: Rehabilitation Authors: Joseph P. Jacob Source Type: research

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Novartis ’ Spinal Drug Gets FDA Approval, $2 Million Price Tag
(CNN) — The US Food and Drug Administration approved a treatment Friday for a genetic disease called spinal muscular atrophy that causes infants’ muscles to waste away, potentially killing them before age 2. And then came the price tag: $2.125 million for a one-time treatment. The gene therapy, called Zolgensma, will be marketed by AveXis, whose parent company is Novartis. “Today’s approval marks another milestone in the transformational power of gene and cell therapies to treat a wide range of diseases,” Dr. Ned Sharpless, the FDA’s acting commissioner, said in a statement Friday. ̶...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 24, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Novartis Source Type: news

Orthopaedic surgery for patients with central nervous system lesions: concepts and techniques
Publication date: Available online 2 October 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): F Genêt, P Denormandie, MA KeenanAbstractSince ancient times, the aim of orthopedic surgery has been to correct limb and joint deformities, including those resulting from central nervous system lesions. Recent developments in the treatment of spasticity have led to changes in concepts and management strategies. The increase in life expectancy has increased the functional needs of patients. Orthopedic surgery, along with treatments for spasticity, improves the functional capacity of patients with neuro-orthopae...
Source: Annals of Physical and Rehabilitation Medicine - October 5, 2018 Category: Rehabilitation Source Type: research

Mechanoadaptation: articular cartilage through thick and thin.
This article is protected by copyright. All rights reserved. PMID: 29917242 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 19, 2018 Category: Physiology Authors: Vincent TL, Wann A Tags: J Physiol Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

CDC Director Resigns Amid Reports of Tobacco Stock Trade
The Department of Health and Human Services (HHS) announced on January 31, 2018, that Dr. Brenda Fitzgerald would resign as the Director of the Centers for Disease Control and Prevention (CDC). The statement read, “Dr. Fitzgerald owns certain complex financial interests that have imposed a broad recusal limiting her ability to complete all of her duties as the CDC Director. Due to the nature of these financial interests, Dr. Fitzgerald could not divest from them in a definitive time period.” The decision came a day after Politico reported that she bought stock in a large tobacco company within a month of start...
Source: Public Policy Reports - February 23, 2018 Category: Biology Authors: AIBS Source Type: news