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Total 133 results found since Jan 2013.

Umbilical Cord Blood Mononuclear Cells for Ex-Vivo Gene Therapy
This study was supported by the grant of Russian Science Foundation No 16-15-00010. Kazan Federal University was supported by the Russian Government Program of Competitive Growth.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Bashirov, F. V., Salafutdinov, I. I., Sokolov, M. E., Izmailov, A. A., Markosyan, V. A., Fadeev, F. O., Rizvanov, A., Islamov, R. I. Tags: 801. Gene Therapy and Transfer Source Type: research

Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia
Conclusions: The results of the study show both the high efficacy and limitations of treatment with eculizumab for PNH in real-world practice. Prospectively confirmed significant improvement of the overall survival on eculizumab stress the need for faster and wider access to costly therapy. Nevertherless, a number of limitations, including BTH and extravascular hemolysis, lack of control of bone marrow failure and further clonal evolution, determine the relevance of next-generation complement inhibitors and risk-adjusted allogeneic HSCT as a curative option.DisclosuresKulagin: Alexion Pharmaceuticals, Inc: Consultancy, Honoraria.
Source: Blood - November 21, 2018 Category: Hematology Authors: Kulagin, A., Klimova, O., Rudakova, T., Golubovskaya, I., Ivanova, M., Smirnova, A., Lapina, A., Bykova, T., Babenko, E., Popova, M., Dobronravov, V., Afanasyev, B. Tags: 508. Bone Marrow Failure: Poster II Source Type: research

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
Publication date: 10–16 November 2018Source: The Lancet, Volume 392, Issue 10159Author(s): Gregory A Roth, Degu Abate, Kalkidan Hassen Abate, Solomon M Abay, Cristiana Abbafati, Nooshin Abbasi, Hedayat Abbastabar, Foad Abd-Allah, Jemal Abdela, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Haftom Temesgen Abebe, Molla Abebe, Zegeye Abebe, Ayenew Negesse Abejie, Semaw F Abera, Olifan Zewdie Abil, Haftom Niguse Abraha, Aklilu Roba AbrhamSummaryBackgroundGlobal development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden ...
Source: The Lancet - November 11, 2018 Category: General Medicine Source Type: research

Ditch the Machine to Improve Accuracy in Blood Pressure Measurement and Diagnostics
Conclusion For the patient in this case, the decision to forego the convenience of a machine in favor of the skills of a knowledgeable paramedic was lifesaving. Much like the comparison often drawn between the old-fashioned barbell and more sophisticated exercise machines, newer, more complex, and more expensive might make a process more comfortable, but doesn’t always equate to superior results. As we surrender more and more of our hands-on skills to the ease of automated technology, we risk more than the loss of the aptitudes that form the foundation of sound patient assessment—we place our patients in jeopardy of mi...
Source: JEMS Special Topics - October 24, 2018 Category: Emergency Medicine Authors: Mark Rock, NRP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Did post-Soviet Russians drink themselves to death?
By Vladimir Popov and Jomo Kwame SundaramMOSCOW and KUALA LUMPUR, Oct 23 2018 (IPS)Although initially obscured by The Economist, among others, the sudden and unprecedented increase in Russian adult male mortality during 1992-1994 is no longer denied. Instead, the debate is now over why?Having advocated ‘shock therapy’, a ‘big bang’, ‘sudden’ or rapid post-Soviet transition, Jeffrey Sachs and others have claimed that the sudden collapse in Russian adult male life expectancy was due to a sudden increase in alcohol consumption, playing into popular foreign images of vodka-binging Russian men. In Russia, vodka is a...
Source: IPS Inter Press Service - Health - October 23, 2018 Category: International Medicine & Public Health Authors: Vladimir Popov and Jomo Kwame Sundaram Tags: Development & Aid Economy & Trade Europe Global Governance Headlines Health TerraViva United Nations Source Type: news

The Russian version of the Oxford Cognitive Screen: Validation study on stroke survivors.
Conclusions: Rus-OCS is a promising cognitive screening instrument for Russian-speaking patients. However, further validation is needed. Constraints of socioeconomic differences between Russian speakers in the wider population should be considered. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Source: Neuropsychology - October 15, 2018 Category: Neurology Source Type: research

Prevalence and Outcomes of Percutaneous Coronary Interventions for Ostial Chronic Total Occlusions: Insights from a Multicenter CTO Registry
ConclusionsOstial CTOs can be recanalized with similar success rates as non-ostial CTOs, but are more complex and more likely to require retrograde crossing, and may be associated with numerically higher risk for major in-hospital complications.
Source: Canadian Journal of Cardiology - July 31, 2018 Category: Cardiology Source Type: research

OnabotulinumtoxinA for the Treatment of Poststroke Distal Lower Limb Spasticity: A Randomized Trial
ConclusionsOnabotulinumtoxinA significantly improved ankle MAS, CGI, and GAS scores compared with placebo; improvements were consistent and increased with repeated treatments of onabotulinumtoxinA over 1 year in patients with PSLLS.Level of EvidenceI
Source: PMandR - July 13, 2018 Category: Rehabilitation Source Type: research

Russian scientists invent an imagination booster for post-stroke patients
(Peter the Great Saint-Petersburg Polytechnic University) Scientists of Peter the Great St. Petersburg Polytechnic University in collaboration with neurophysiologists from Sechenov Institute of evolutionary physiology and biochemistry formed the innovative startup iBrain have developed a unique play structure for post-stroke patients rehabilitation as part of Project 5-100. According to the press service of the university, leading specialists in the sphere of artificial intelligence augmented physical exercise for restoring motor functions with playing with imagination which enables the patient to move.
Source: EurekAlert! - Medicine and Health - July 6, 2018 Category: International Medicine & Public Health Source Type: news

Effectiveness of Faradic and Russian currents on plantar flexor muscle spasticity, ankle motor recovery, and functional gait in stroke patients
Physiotherapy Research International, EarlyView.
Source: Physiotherapy Research International - February 8, 2018 Category: Physiotherapy Source Type: research

OnabotulinumtoxinA for the Treatment of Post-Stroke Distal Lower-Limb Spasticity: A Randomized Trial
Conclusions OnabotulinumtoxinA significantly improved ankle MAS, CGI, and GAS scores compared with placebo; improvements were consistent and increased with repeated treatments of onabotulinumtoxinA over 1 year in patients with PSLLS. Clinical Trial Registration URL: https://clinicaltrials.gov/ct2/show/NCT01575054?term=NCT01575054&rank=1
Source: PMandR - January 10, 2018 Category: Rehabilitation Source Type: research

Effectiveness of Faradic and Russian currents on plantar flexor muscle spasticity, ankle motor recovery, and functional gait in stroke patients
ConclusionAdding ES to exercises are associated with low to medium effect sizes (<0.5) in reducing spasticity and improving ankle ROM.
Source: Physiotherapy Research International - January 1, 2018 Category: Physiotherapy Authors: G. Shankar Ganesh, Ranjita Kumari, Monalisa Pattnaik, Patitapaban Mohanty, Chittaranjan Mishra, Parminder Kaur, Anandhi Dakshinamoorthy Tags: RESEARCH ARTICLE Source Type: research

InspireMD touts 2-year CGuard EPS results
InspireMD (NYSE:NSPR) this week released two-year results from the Paradigm 101 clinical study of its CGuard embolic protection system. Results from the trial were initially presented at the 2017 VEITH Symposium in New York last month. In the investigator-led study, researchers examined the use of the CGuard EPS system in 101 patients with symptomatic or high-risk asymptomatic carotid artery stenosis. Data from the study indicated that there were no deaths, major stroke or myocardial infarctions as a result of periprocedural or postprocedural interventions at at two years. InspireMD said that the results were consistent w...
Source: Mass Device - December 6, 2017 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Neurological InspireMD Source Type: news

A Leonardo da Vinci Painting Just Sold for $450 Million. Here ’s How Experts Figured Out It Was Real
For a painting worth nearly half a billion dollars, Leonardo da Vinci’s Salvator Mundi is far from perfect. The 500-year-old portrait of Jesus Christ has a shady past that includes ownership by King Charles I, a 160-year disappearing act and a sale for only thousands of dollars just 12 years ago. It is damaged and was heavily repainted, then restored. And at least one prominent da Vinci expert is on record saying he doesn’t believe da Vinci was the primary artist behind it. But the 15-by-17 portrait overcame all of that Wednesday night when it sold at auction to an anonymous buyer for a gob-smacking $450.3 mil...
Source: TIME.com: Top Science and Health Stories - November 17, 2017 Category: Consumer Health News Authors: Jennifer Calfas Tags: Uncategorized Art onetime Source Type: news

Russian study pits InspireMD ’ s CGuard device against Abbott ’ s Rx Acculink carotid stent
InspireMD (NYSE:NSPR) this week touted an independent clinical trial in Russia pitting its CGuard embolic protection device against the Rx Acculink carotid stent made by Abbott (NYSE:ABT). The 100-patient trial is designed to compare the two devices in terms of neuroprotection and clinical superiority in subjects undergoing carotid endarterectomy, the Tel Aviv-based company said. Conducted at the Scientific Research Institute of Circulation Pathology in Novosibirsk, the study is led by Dr. Andrei Karpenko. The primary endpoint is new ischemic areas in the brain 24 to 48 hours post-procedure and new lesion permanence at...
Source: Mass Device - October 12, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Clinical Trials Stents InspireMD Stroke Source Type: news