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Cancer: Sarcomas

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Total 120 results found since Jan 2013.

LM02 trial Perioperative treatment with panitumumab and FOLFIRI in patients with wild-type RAS, potentially resectable colorectal cancer liver metastases —a phase II study
ConclusionsPanitumumab and FOLFIRI as perioperative therapy for resectable CLM result in a radiological objective response rate in 65.7% of patients with a manageable grade 3 diarrhea rate of 14.3%. Median PFS was 13.2 months, and the 24-month OS rate was 73.3%. These data are insufficient to widen the indication of panitumumab from the unresectable setting to the setting of resectable CLM.
Source: Frontiers in Oncology - August 9, 2023 Category: Cancer & Oncology Source Type: research

A case of acute ischemic stroke caused by doxorubicin-induced cardiomyopathy in a patient with synovial sarcoma
Source: Acta Neurologica Belgica - March 30, 2023 Category: Neurology Source Type: research

A case report of an ischaemic stroke, caused by a primary cardiac intimal sarcoma
We present a case of intimal sarcoma identified without any cardiac s...
Source: BMC Cardiovascular Disorders - February 1, 2023 Category: Cardiology Authors: Joshua Lloyd, Navinee Gilliat, Graeme Porter and Francesco Pirone Tags: Case Report Source Type: research

Carotid Intimal Sarcoma Presenting as Large Vessel Occlusion and Diagnosed by Embolus Histopathology: Case Report
We report the case of a patient who presented with acute embolic ischemic stroke and was found to have IS based on a histopathologic evaluation of his embolectomy specimen. Subsequent comprehensive imaging studies failed to detect a primary tumor site. Multidisciplinary interventions including a course of radiotherapy were performed. The patient died of recurrent multifocal strokes 92 days after diagnosis. Discussion Meticulous histopathologic analysis should be conducted on cerebral embolectomy specimens. Histopathology may be useful in diagnosing IS.
Source: Neurology Clinical Practice - January 19, 2023 Category: Neurology Authors: Johnson, M. D., Rogers, E. J., Khan, M. W., McMullen, P. D., Akkipeddi, S. M. K., Mattingly, T., Benesch, C. G., Bender, M. T. Tags: Clinical/Scientific Note Source Type: research

Investigation into the potential mechanism and molecular targets of Fufang Xueshuantong capsule for the treatment of ischemic stroke based on network pharmacology and molecular docking
Fufang Xueshuantong (FFXST) capsule is a traditional Chinese medicine (TCM) preparation used to activate blood circulation, resolve stasis, benefit qi, and nourish yin in clinical practice. However, its potential mechanism and molecular targets after ischemic stroke (IS) have not been investigated. The aim of this research was to investigate the molecular mechanisms of FFXST in the treatment of IS based on network pharmacology and molecular docking. We used the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) to collect candidate compounds of four herbs in FFXST; disease-related diff...
Source: Frontiers in Pharmacology - September 15, 2022 Category: Drugs & Pharmacology Source Type: research

FUS aggregation following ischemic stroke favors brain astrocyte activation through inducing excessive autophagy
In conclusion, our results reveal the important contribution of FUS aggregates in promoting astrocyte activation in stroke pathology independent of its transcriptional regulation activity. We thus propose that aggregation of FUS is an important pathological process in ischemic stroke and targeting FUS aggregates might be of unique therapeutic value in the development of future treatment strategies for ischemic stroke.PMID:35718207 | DOI:10.1016/j.expneurol.2022.114144
Source: Experimental Neurology - June 19, 2022 Category: Neurology Authors: Shusheng Wu Yuye Yin Longfei Du Source Type: research

Acroangiodermatitis presenting as unilateral hypertrophic verrucous plaques
Dermatol Online J. 2022 Mar 15;28(2). doi: 10.5070/D328257400.ABSTRACTAcroangiodermatitis (AAD)[KL1] is a rare vasoproliferative disorder often involving the extremities that has been classified into two variants. Mali-type AAD is more common and associated with chronic venous stasis. Stewart-Bluefarb syndrome[KL2], the other variant, is associated with underlying arteriovenous abnormalities. Mali-type AAD is a relatively benign diagnosis but it may mimic more harmful etiologies such as Kaposi sarcoma both clinically and histologically. A 67-year-old woman with a history of varicose veins, deep vein thrombosis, stroke, and...
Source: Dermatol Online J - June 7, 2022 Category: Dermatology Authors: Kyle Lauck Quoc-Bao Nguyen Natasha Klimas Megan Rogge Source Type: research