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Total 496 results found since Jan 2013.

Management of Anticoagulation in Cancer Patients with Atrial Fibrillation
Isr Med Assoc J. 2022 Mar;24(3):183-185.ABSTRACTAtrial fibrillation is becoming an increasingly important problem in cardio-oncology. Specific risk factors for atrial fibrillation occurrence include type of cancer disease and anticancer drugs. Anticoagulation is often abandoned. The CHA2DS2-VASc and CHA2DS2 scores may be important not only in predicting stroke but also in mortality. The role of new direct oral anticoagulants is growing, but they need to be used in a personalized approach depending on the risk of unbeneficial interactions with cancer treatment and the risk of bleeding.PMID:35347933
Source: The Israel Medical Association Journal - March 29, 2022 Category: General Medicine Authors: Sebastian Szmit Jaros ław Kępski Michal Wilk Source Type: research

Patient suitability for free water protocols in acute stroke and general medicine: a qualitative study of clinician perceptions
CONCLUSIONS & IMPLICATIONS: Despite the benefits of FWPs in other settings, in acute stroke and general medicine, clinicians erred on the side of safety and, in most cases, would not implement an FWP. Future clinical research is needed to systematically design high-quality and feasible clinical trials to determine the benefits and safety of FWPs for patients with dysphagia in these settings. This would lay the foundations for guidelines to support the complex clinical decision-making regarding patient suitability for FWPs.WHAT THIS PAPER ADDS: What is already known on the subject FWPs are an alternate management strategy f...
Source: International Journal of Language and Communication Disorders - March 23, 2022 Category: Speech-Language Pathology Authors: Joanne Murray Shannon Maloney Kaitlyn Underdown Sebastian Doeltgen Source Type: research

The Impact of Nasogastric Feeding Tube on Physiologic Swallow in Head and Neck Cancer Patients: A Multidisciplinary Clinical Trial
Nasogastric feeding tubes (NGT) are ubiquitous within the head and neck (H&N) cancer patient population. NGT are often placed in post-surgical H&N cancer patients to allow for healing of suture lines in oral cavity and oropharyngeal free flap patients and are also used in transoral robotic surgery (TORS) patients. Despite their widespread use, the impact of NGT on the physiologic swallow of H&N cancer patients remains unknown. In the neurology literature, there is data demonstrating alterations in the functional swallow of elderly post-stroke patients with NGTs.
Source: International Journal of Radiation Oncology * Biology * Physics - March 11, 2022 Category: Radiology Authors: M.N. Stevens, E. Hosokawa, A. Hereford, M. West, R. Fleming, K. Sharif, R. Sinard, S.L. Rohde, K. Mannion, A. Langerman, J. Netterville, E.L. Rosenthal, M.C. Topf Tags: 215 Source Type: research

New ERLEADA ® (apalutamide) Analysis Demonstrates Rapid, Deep Prostate-Specific Antigen (PSA) Response in Patients with Metastatic Castration-Sensitive Prostate Cancer (mCSPC)
SAN FRANCISCO, Feb. 14, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new real-world evidence data showing the initiation of ERLEADA® (apalutamide) results in high rates of rapid and deep prostate-specific antigen (PSA) response among patients with metastatic castration-sensitive prostate cancer (mCSPC). In a separate post-hoc analysis of the registrational Phase 3 SPARTAN and TITAN studies, rapid and deep PSA responses with ERLEADA® were associated with improvement in patient-reported outcomes (PROs) related to quality of life, physical wellbeing, pain, and fatigue intensity. The...
Source: Johnson and Johnson - February 14, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials
CONCLUSION: Based on the current evidence, piperine can be the potential molecule for treatment of disease, and its significance of this molecule in the clinic is discussed.PMID:35127957 | PMC:PMC8796742 | DOI:10.1186/s43088-022-00196-1
Source: Appl Human Sci - February 7, 2022 Category: Physiology Authors: Amit Kumar Tripathi Anup Kumar Ray Sunil Kumar Mishra Source Type: research

Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Psychometric properties of the EQ-5D-3L in South Australia: a multi-method non-preference-based validation study
This study aims to psychometrically validate the EQ-5D-3L in a large population sample in Australia for the first time.METHODS: The EQ-5D-3L was included in the Dental Care and Oral Health study (DCOHS), conducted in a South Australian population sample. The participants were 23-91 years old, and 44.1% were male. The EQ-5D-3L was responded to on a three-point rating scale ("none"/"no", "some" and "extremely"/"unable"/"confined"). We employed the area under the receiver operating characteristic curve (AUROC) to evaluate whether the EQ-5D-3L total score could identify participants with diagnosed diseases and mental health di...
Source: Current Medical Research and Opinion - January 21, 2022 Category: Research Authors: Mehrsa Zakershahrak Pedro H Ribeiro Santiago Sneha Sethi Dandara Haag Lisa Jamieson David Brennan Source Type: research

Ditching cigarettes for smokeless tobacco can help cut cardiovascular risks, study finds
Regular smokers are at heightened risk of developing cardiovascular disease, but crushing the butts in favor of a “smokeless” alternative like chewing tobacco, snuff or tobacco lozenges may go a long way toward bringing the danger down to a more normal level, a new UCLA-led study shows.The findings also indicate that the primary culprit in smokers ’ increased risk is not nicotine but other chemicals found in tobacco smoke. Both cigarettes and smokeless tobacco products contain large quantities of nicotine.The study,published today in the journal Nicotine and Tobacco Research, involved a team of researchers from UCLA...
Source: UCLA Newsroom: Health Sciences - January 6, 2022 Category: Universities & Medical Training Source Type: news

Comparative Cardio-Renal Outcomes of Type 2 Diabetes Patients Administered Glucagon-Like Peptide-1 Receptor Agonists: A Network Meta-Analysis
Conclusion: Semaglutide should be considered when GLP-1 RAs are indicated for T2DM patients.
Source: Frontiers in Pharmacology - December 24, 2021 Category: Drugs & Pharmacology Source Type: research

Fatal Adverse Events of Dabigatran Combined With Aspirin in Elderly Patients: An Analysis Using Data From VigiBase
Conclusion: The fatal adverse events associated with the combined use of dabigatran and aspirin in elderly patients were mainly serious bleeding events, which often occurred within 1 month. Most of these cases had medication errors and most of the patients had multiple diseases, medications, or other conditions at the same time that increase the risk of bleeding. It is suggested that prescription of dabigatran and aspirin in elderly patients should go along with alertness for medication errors, care for correct dose or control of other bleeding risk factors, and the combined medication time should be as short as possible ...
Source: Frontiers in Pharmacology - December 22, 2021 Category: Drugs & Pharmacology Source Type: research