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Ask JJ: Type 2 Diabetes
Dear JJ: My doctor just diagnosed me with pre-diabetes. Type 2 diabetes runs in my family, but I will not accept it as my fate. You've written about sugar's detrimental impact, so how can I get this under control so it doesn't blow up into full-blown diabetes?
Diabetes doesn't happen overnight or linearly, but when your metabolic machinery breaks, serious havoc ensues. The massive repercussions can become deadly.
Every time you eat, you raise blood sugar, which triggers your pancreas to release a hormone called insulin. Every food raises blood sugar, but high-sugar impact foods do it big time.
Your pancreas "secretes s...
Source: Healthy Living - The Huffington Post - June 16, 2016 Category: Consumer Health News Source Type: news
Coconut Oil: Why You Should Question the Hype
by Carra Richling
Coconut has become a popular and trendy "super food." Ever since some preliminary research started claiming that it can cure everything from heart disease to Alzheimer's, and even aid in weight loss, coconut products have flooded the market. They include coconut oils, margarines, milks, yogurts and ice cream, and many products are substituting in coconut oil in order to gain market value.
There is, however, still a dearth of validated scientific research on the benefits of coconut, so it remains unclear whether or not the trend is the result of marketing hype. For example, the Alzheimer's Association no...
Source: Healthy Living - The Huffington Post - June 22, 2016 Category: Consumer Health News Source Type: news
He Did Not Cry Wolf: The Case of a Man With Lupus and 10 Years of Dysphagia
Question: A 64-year-old man with systemic lupus erythematosus was referred for evaluation of dysphagia and regurgitation. The patient reported a 10-year history of difficulty swallowing solid foods with associated burning substernal chest discomfort. He was not symptomatic with drinking, but his symptoms progressed, and he developed occasional regurgitation. He was treated empirically for gastroesophageal reflux disease with esomeprazole 20 mg/d; however, he noted persistent symptoms. He did not report weight loss, neurologic deficits, or prior stroke.
Source: Gastroenterology - June 30, 2016 Category: Gastroenterology Authors: Shelly Gurwara, Tomas DaVee, Michael F. Vaezi Tags: Clinical Challenges and Images in GI Source Type: research
Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
Publication date: Available online 27 June 2016 Source:Japanese Dental Science Review Author(s): Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with ch...
Source: Japanese Dental Science Review - July 27, 2016 Category: Dentistry Source Type: research
Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes: Cardiovascular and Kidney Effects, Potential Mechanisms and Clinical Applications.
Abstract
Sodium glucose co-transporter-2 (SGLT2) inhibitors, including empagliflozin, dapagliflozin and canagliflozin, are now widely approved anti-hyperglycemic therapies. Due to their unique glycosuric mechanism, SGLT2 inhibitors also reduce weight. Perhaps more importantly are osmotic diuretic and natriuretic effects contributing to plasma volume contraction, and decreases in systolic and diastolic blood pressures (BP) by 4-6/1-2 mmHg, respectively, which may underlie cardiovascular and kidney benefits. SGLT2 inhibition is also associated with an acute, dose-dependent reduction in eGFR by ~5 ml/min/1.73m(2) and...
Source: Circulation - July 27, 2016 Category: Cardiology Authors: Heerspink HJ, Perkins BA, Fitchett DH, Husain M, Cherney DZ Tags: Circulation Source Type: research
Leading Health Mistakes Women Make In Their 30s
Credit
For many women, turning 30 marks the real beginning of adulthood. You're established in a career, and maybe in a relationship. You might be thinking about starting a family. You feel pretty good about yourself, and all the health indiscretions of your 20s (remember those all-night parties and how you still managed to make it into work the next day?) haven't taken much of a health toll.
But let's face it, ages 30 to 39 are prime time. All in all, the 30s are a very positive time for health, but it's also the time you have to start developing excellent habits as an investment in the future, says Dr. Debra DeJoseph,...
Source: Healthy Living - The Huffington Post - August 17, 2016 Category: Consumer Health News Source Type: news
TNP N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Conclusion We demonstrate that pharmacologic inhibition of the inositol pyrophosphate pathway has strong therapeutic potential in obesity, T2D, and other metabolic diseases.
Source: Molecular Metabolism - August 20, 2016 Category: Endocrinology Source Type: research
Want Your Teen To Have A Healthy Weight? Science Says Shut Up
Experts agree that talking about the need to diet and lose weight is one of the most unhealthy, counterproductive things a parent can do for a teen who is struggling with weight issues.
Now, new guidelines from the American Academy of Pediatrics formally endorse those findings. In order to prevent obesity and eating disorders, parents should focus less on diets and the scale and emphasize family togetherness and exercise for fitness, not weight loss. The AAP included both obesity and eating disorders in their recommendations because these often share unhealthy behaviors such as dieting, bingeing and having a diss...
Source: Science - The Huffington Post - August 23, 2016 Category: Science Source Type: news
Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial
We examined whether the incidence of cardiovascular disease in Look AHEAD varied by changes in weight or fitness. Methods Look AHEAD was a randomised clinical trial done at 16 clinical sites in the USA, recruiting patients from Aug 22, 2001, to April 30, 2004. In the trial, 5145 overweight or obese adults aged 45–76 years with type 2 diabetes were assigned (1:1) to an intensive lifestyle intervention or diabetes support and education. In this observational, post-hoc analysis, we examined the association of magnitude of weight loss and fitness change over the first year with incidence of cardiovascular disease. The primar...
Source: The Lancet Diabetes and Endocrinology - August 30, 2016 Category: Endocrinology Source Type: research
How Your Brain Is Making You Fat (And What To Do About It)
Thousands of Americans woke up this morning and declared, "Today is the day I start my diet. Er, well, maybe tomorrow."
When you start that diet is probably irrelevant anyway. "Only 3 out of every 100 people who reach their goal manage to maintain that weight loss beyond the first year." Three! Yup, "losing weight" is no longer just an idealistic New Year's resolution; it's a daily tradition.
Why is it that human beings can shoot a rocket into space, climb Everest,
but can't refuse a piece of chocolate cake?
It's not a lack of willpower. Processed foods have changed the way our brain chemistry to a point that our bod...
Source: Healthy Living - The Huffington Post - September 22, 2016 Category: Consumer Health News Source Type: news
P05.04 Morphine pretreatment improves the therapeutic efficacy of doxorubicin in an orthotopic model of human glioblastoma
Conclusions:The present findings show that molecules as morphine are able to interfere with molecules normally unable to cross the BBB. This mechanism could be used for new approaches in therapy of refractory CNS tumors as glioblastoma.
Source: Neuro-Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Da Ros, M. Tags: P05 In vitro / in vivo models Source Type: research
Borderline operability in hepatectomy patients is associated with higher rates of failure to rescue after severe complications
ConclusionsHepatectomy patients meeting BL criteria have an overall post‐hepatectomy mortality rate that is triple that of non‐BL patients. With less clinical reserve, BL patients who suffer SC are at greater risk of post‐hepatectomy death. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - November 2, 2016 Category: Cancer & Oncology Authors: Bradford J. Kim, Ching ‐Wei D. Tzeng, Amanda B. Cooper, Jean‐Nicolas Vauthey, Thomas A. Aloia Tags: Research Article Source Type: research
The use of commercial video games in rehabilitation: a systematic review
The aim of this paper was to investigate the effect of commercial video games (VGs) in physical rehabilitation of motor functions. Several databases were screened (Medline, SAGE Journals Online, and ScienceDirect) using combinations of the following free-text terms: commercial games, video games, exergames, serious gaming, rehabilitation games, PlayStation, Nintendo, Wii, Wii Fit, Xbox, and Kinect. The search was limited to peer-reviewed English journals. The beginning of the search time frame was not restricted and the end of the search time frame was 31 December 2015. Only randomized controlled trial, cohort, and observa...
Source: International Journal of Rehabilitation Research - November 3, 2016 Category: Rehabilitation Tags: Review article Source Type: research
