Review of systematic reviews on mandibular advancement oral appliance for obstructive sleep apnea: The importance of long-term follow-up
Publication date: December 2020Source: Japanese Dental Science Review, Volume 56, Issue 1Author(s): Kazumichi Sato, Tsuneya NakajimaSummaryThe purpose of this review was to present the currently available information on oral appliance (OA) therapy for dentists, especially clinic-based dentists, to aid them in performing this treatment for the management of symptoms of obstructive sleep apnea (OSA). The clinical research evidence comprised of systematic reviews concerned with the mandibular advancement oral appliance (OAm). Continuous positive airway pressure (CPAP) is superior to OA therapy in improving OSA symptoms. It is...
Source: Japanese Dental Science Review - December 3, 2019 Category: Dentistry Source Type: research

The microtensile bond strength test: Its historical background and application to bond testing
Publication date: December 2020Source: Japanese Dental Science Review, Volume 56, Issue 1Author(s): Hidehiko Sano, Abu Faem Mohammad Almas Chowdhury, Pipop Saikaew, Mariko Matsumoto, Shuhei Hoshika, Monica YamautiSummaryMicrotensile bond strength (μTBS) test was introduced in 1994. Since then, it has been utilized profoundly across many bond strength testing laboratories, making it currently one of the most standard and versatile bond strength test. Although it is a static and strength-based method, together with the morphological and spectroscopic investigations, it has been contributing immensely in the advancement of...
Source: Japanese Dental Science Review - November 26, 2019 Category: Dentistry Source Type: research

Strength and aging resistance of monolithic zirconia: an update to current knowledge
Publication date: December 2020Source: Japanese Dental Science Review, Volume 56, Issue 1Author(s): Eleana Kontonasaki, Panagiotis Giasimakopoulos, Athanasios E. RigosAbstractNew zirconia compositions with optimized esthetic properties have emerged due to the fast-growing technology in zirconia manufacturing. However, the large variety of commercial products and synthesis routes, make impossible to include all of them under the general term of “monolithic zirconia ceramics”. Ultra- or high translucent monolithic formulations contain 3–8 mol% yttria, which results in materials with completely differen...
Source: Japanese Dental Science Review - November 15, 2019 Category: Dentistry Source Type: research

Maintaining occlusal stability by selecting the most appropriate occlusal scheme in complete removable prosthesis
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Sara Sabir, Anissa Regragui, Nadia MerzoukAbstractThe search of an adequate occlusal scheme that maximizes dentures’ stability and patients’ satisfaction is an ultimate objective in every complete prosthodontic treatment. Many studies compared occlusal schemes in terms of retention, comfort and masticatory performance. The purpose of this article is to review literature about different occlusal schemes related to complete dentures’ stability and edentulous patients’ satisfaction, in order to select th...
Source: Japanese Dental Science Review - November 7, 2019 Category: Dentistry Source Type: research

Resin based restorative dental materials: characteristics and future perspectives
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Bhanu Pratap, Ravi Kant Gupta, Bhuvnesh Bhardwaj, Meetu NagAbstractThis review article compiles the characteristics of resin based dental composites and an effort is made to point out their future perspectives. Recent research studies along with few earlier articles were studied to compile the synthesis schemes of commonly used monomers, their characteristics in terms of their physical, mechanical and polymerization process with selectivity towards the input parameters of polymerization process. This review covers surface mo...
Source: Japanese Dental Science Review - October 23, 2019 Category: Dentistry Source Type: research

B cell dysregulation in primary Sjögren’s syndrome: A review
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Hazim Mahmoud IbrahemAbstractPrimary Sjögren’s syndrome is a chronic autoimmune disorder of unknown etiology and is characterized by progressive focal lymphocytic infiltration of the lacrimal and salivary glands. Comparison of B cell subsets from the peripheral blood and salivary glands of patients with primary Sjögren’s syndrome and those from healthy individuals shows dysregulation and derangement of B cell subsets in both peripheral circulation and in inflamed glandular tissues. This dysregulation is...
Source: Japanese Dental Science Review - October 23, 2019 Category: Dentistry Source Type: research

Immunomodulatory aspects in the progression and treatment of oral malignancy
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Nobuo Kondoh, Masako Mizuno-Kamiya, Naoki Umemura, Eiji Takayama, Harumi Kawaki, Kenji Mitsudo, Yasunori Muramatsu, Shinichiro SumitomoAbstractInflammation substantially affects the risk of oral malignancy. Pro-inflammatory cytokine, interferon (IFN)-γ, confers anti-tumor activity using several different mechanisms. Conversely, higher expression of interleukin (IL)-17 is associated with worse prognosis. Monocyte chemotactic protein (MCP)-1 correlates positively with poor long-term survival of head and neck squamous cel...
Source: Japanese Dental Science Review - October 9, 2019 Category: Dentistry Source Type: research

Social contribution of forensic odontology in Japan
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Toshinobu Komuro, Hirofumi Tsutsumi, Hikaru Izawa, Seiko Katsumura, Hisako Saitoh, Koichi Sakurada, Keita Sato, Akira FurukawaAbstractHalf a century has passed since the department for education and research on forensic odontology was established at dentistry-related universities in Japan in 1964. In order to meet the demands of society, the number of universities with a department of forensic odontology increased up until around 2005. In 2007, the Japanese Society of Forensic Dental Science was established, and then a serie...
Source: Japanese Dental Science Review - October 9, 2019 Category: Dentistry Source Type: research

Obesity-induced asthma: Role of free fatty acid receptors
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Kentaro Mizuta, Atsuko Matoba, Sumire Shibata, Eiji Masaki, Charles W. Emala SrAbstractObesity is a major risk factor for the development of asthma, and worsens the key features of asthma including airway hyperresponsiveness, inflammation, and airway remodeling. Although pro- and anti-inflammatory adipocytokines may contribute to the pathogenesis of asthma in obesity, the mechanistic basis for the relationship between asthma and obesity remains unclear. In obese individuals, the increased amount of adipose tissue results in ...
Source: Japanese Dental Science Review - August 30, 2019 Category: Dentistry Source Type: research

Comparison of the quality assurance system of dental professionals in Japan, the EU and the ASEAN
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Jun TsurutaAbstractIn recent years, the society requires a flexible response of the dental society to deal with changes in disease structure in the super-aging society in Japan. Regarding quality of dental care, we need to ensure quality of clinical environment, dental professionals and the system. As globalization expands, the health care professionals move to another country to work. In the European Union(EU), the quality assurance system for the graduated European dentist through the activities in undergraduate education ...
Source: Japanese Dental Science Review - August 30, 2019 Category: Dentistry Source Type: research

Novel insight into the management of bisphosphonate-related osteonecrosis of the jaw (BRONJ)
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Hiromitsu Kishimoto, Kazuma Noguchi, Kazuki TakaokaSummaryBisphosphonate-related osteonecrosis of the jaw (BRONJ), characterized by refractory bone exposure, has recently emerged as a serious side effect of bisphosphonate (BPs) treatment. We discuss novel insights that may help to improve the efficacy of BRONJ treatment and prevention. Our report highlights the following: (1) The presence of exposed bone in patients taking BPs does not necessarily reflect BRONJ, and diagnoses of oral ulceration with bone sequestration and ma...
Source: Japanese Dental Science Review - May 18, 2019 Category: Dentistry Source Type: research

Smoking and periodontal microorganisms
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Takashi Hanioka, Manabu Morita, Tatsuo Yamamoto, Koji Inagaki, Pao-Li Wang, Hiroshi Ito, Toshiya Morozumi, Toru Takeshita, Nao Suzuki, Hideo Shigeishi, Masaru Sugiyama, Kouji Ohta, Toru Nagao, Nobuhiro Hanada, Miki Ojima, Hiroshi OgawaSummaryResolution of dysbiosis following treatment for periodontal disease and tobacco dependence has been reported in longitudinal intervention studies. In the present report, we evaluated the biological findings regarding the effect of smoking on the periodontal microbiome. A standardized ele...
Source: Japanese Dental Science Review - April 26, 2019 Category: Dentistry Source Type: research

R-spondin signaling as a pivotal regulator of tissue development and homeostasis
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Kenichi NaganoAbstractR-spondins (Rspos) are cysteine-rich secreted glycoproteins which control a variety of cellular functions and are essential for embryonic development and tissue homeostasis. R-spondins (Rspo1 to 4) have high structural similarity and share 60% sequence homology. It has been shown that their cysteine-rich furin-like (FU) domain and the thrombospondin (TSP) type I repeat domain are essential for initiating downstream signaling cascades and therefore for their biological functions. Although numerous studie...
Source: Japanese Dental Science Review - April 24, 2019 Category: Dentistry Source Type: research

☆Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (5), utility of bone scintigraphy and 18F-FDG PET/CT in early detection and risk assessment of medication-related osteonecrosis of the jaw (secondary publication)
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Satoru Watanabe, Kenichi Nakajima, Seigo KinuyaSummaryMedication-related osteonecrosis of the jaw (MRONJ) is a significant side effect of antiresorptive and antiangiogenic drugs. Since MRONJ is intractable, early detection is the best way to limit progression. Bone scintigraphy and 18F- fluorodeoxyglucose positron-emission tomography can detect minimal and subclinical changes in bones earlier than conventional radiological modalities. A differential diagnosis including MRONJ is recommended when abnormally high uptakes are in...
Source: Japanese Dental Science Review - March 22, 2019 Category: Dentistry Source Type: research

Imaging modalities for drug-related osteonecrosis of the jaw (2), Overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan
This article presents an overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - March 20, 2019 Category: Dentistry Source Type: research

Imaging modalities for drug-related osteonecrosis of the jaw (3), Positron emission tomography imaging for the diagnosis of medication-related osteonecrosis of the jaw
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Yoshimasa Kitagawa, Noritaka Ohga, Takuya Asaka, Jun Sato, Hironobu Hata, Joseph Helman, Kanako Tsuboi, Norio Amizuka, Yuji Kuge, Tohru ShigaSummaryMedication-related osteonecrosis of jaws (MRONJ) is one of the most complicated inflammatory conditions in oral and maxillofacial region. It is very difficult to correctly evaluate the degree and extent of necrosis and infection. This refractory osteonecrosis often needs extended surgery, leading to impaired quality-of-life. We have performed hyperbaric oxygen therapy (HBO) combi...
Source: Japanese Dental Science Review - March 17, 2019 Category: Dentistry Source Type: research

Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (6), assessment of mandibular metabolism due to long-term administration of an anti-resorptive agent by bone scintigraphy (secondary publication)
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Yumiko Ohbayashi, Fumi Nakai, Akinori Iwasaki, Takaaki Ogawa, Yuka Yamamoto, Yoshihiro Nishiyama, Minoru MiyakeSummaryIt is not yet known why anti-resorptive agent-related osteonecrosis specifically affects the jaw. Here we assessed changes in the bone metabolism of the mandible in response to long-term bisphosphonate (BP) therapy, and we compared the bone metabolism changes of the mandible with those of other bone sites using a quantitative analysis by bone scintigraphy. The region of interest was selected by identifying wi...
Source: Japanese Dental Science Review - February 16, 2019 Category: Dentistry Source Type: research

Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (4), CT and MR imaging findings of antiresorptive agent-related osteonecrosis of the jaws/medication-related osteonecrosis of the jaw (secondary publication)
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Akira Baba, Hiroya Ojiri, Tazuko K. Goto, Koshi Ikeda, Hideomi Yamauchi, Nobuhiro Ogino, Takuji MogamiSummaryGenerally, CT and MR images of antiresorptive agent-related osteonecrosis of the jaw (ARONJ)/medication-related osteonecrosis of the jaw (MRONJ) show nonspecific findings as seen in active osteomyelitis.However, there are some characteristics as follows; unilateral maxillary sinusitis adjacent to ipsilateral maxillary ARONJ/MRONJ, DRONJ presenting larger sequestrum and periosteal reaction more frequently than BRONJ,...
Source: Japanese Dental Science Review - February 16, 2019 Category: Dentistry Source Type: research

Symposium: Imaging modalities for drug-related osteonecrosis of the jaw (1), role of imaging in drug-related osteonecrosis of the jaw: An up-to-date review (secondary publication)
Publication date: November 2019Source: Japanese Dental Science Review, Volume 55, Issue 1Author(s): Makoto Tsuchimochi, Tohru KurabayashiSummaryMRONJ/ARONJ is a serious adverse effect of medication, although the incidence of the disease is rare, and there are still controversial issues regarding the pathogenesis of MRONJ/ARONJ. Medications that can lead to MRONJ/ARONJ are commonly used to treat osteoporosis and to prevent bone fractures caused by bone metastasis of malignancies. The long-standing disease state of ONJ deteriorates the quality of life of affected patients. Early detection and prevention of the disease are ke...
Source: Japanese Dental Science Review - January 18, 2019 Category: Dentistry Source Type: research

Effectiveness of current adhesive systems when bonding to CAD/CAM indirect resin materials: A review of 32 publications
Publication date: Available online 23 November 2018Source: Japanese Dental Science ReviewAuthor(s): Atsushi Mine, Tomoshige Kabetani, Asuka Kawaguchi-Uemura, Mami Higashi, Yuko Tajiri, Ryosuke Hagino, Dai Imai, Masahiro Yumitate, Shintaro Ban, Mariko Matsumoto, Hirofumi YataniSummaryThe purpose of this review was to assess the available literature regarding bonding between current adhesive systems and computer-aided design/computer-aided manufacturing (CAD/CAM) indirect resin materials, to provide clinicians with a comparative overview of the relevant bonding procedures. An electronic search was performed through PubMed ba...
Source: Japanese Dental Science Review - November 24, 2018 Category: Dentistry Source Type: research

Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
We describe that Fas/S1P1 signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - October 27, 2018 Category: Dentistry Source Type: research

Comparison of immediate and conventional loading protocols with respect to marginal bone loss around implants supporting mandibular overdentures: A systematic review and meta-analysis
ConclusionThe MBLCs of immediately-loaded implants for mandibular IODs seems comparable to those of conventional loading. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - October 25, 2018 Category: Dentistry Source Type: research

Bone grafting materials in dentoalveolar reconstruction: A comprehensive review
Publication date: Available online 28 September 2018Source: Japanese Dental Science ReviewAuthor(s): S. Titsinides, G. Agrogiannis, T. KaratzasSummaryBone deficits of the jaws are often attributed to accidents, surgical removal of benign lesions or malignant neoplasms, congenital abnormalities, periodontal inflammation, tooth abscess or extraction and finally jaw atrophy due to advanced age or general disease.These bone defects require rehabilitation for a variety of reasons, e.g. maintaining the normal anatomic outline, eliminating empty space, aesthetic restoration and placing dental implants. Today, several techniques h...
Source: Japanese Dental Science Review - October 5, 2018 Category: Dentistry Source Type: research

Current and future options for dental pulp therapy
Publication date: Available online 29 September 2018Source: Japanese Dental Science ReviewAuthor(s): Takahiko Morotomi, Ayako Washio, Chiaki KitamuraSummaryDental pulp is a connective tissue and has functions that include initiative, formative, protective, nutritive, and reparative activities. However, it has relatively low compliance, because it is enclosed in hard tissue. Its low compliance against damage, such as dental caries, results in the frequent removal of dental pulp during endodontic therapy. Loss of dental pulp frequently leads to fragility of the tooth, and eventually, a deterioration in the patient’s qu...
Source: Japanese Dental Science Review - October 5, 2018 Category: Dentistry Source Type: research

Treatment and evaluation of dysphagia rehabilitation especially on suprahyoid muscles as jaw-opening muscles
In this study, we describe a new dysphagia evaluation method and an exercise that focuses on suprahyoid muscles with application of jaw-opening actions. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - September 10, 2018 Category: Dentistry Source Type: research

Association of feeding behavior with jaw bone metabolism and tongue pressure
Publication date: Available online 3 September 2018Source: Japanese Dental Science ReviewAuthor(s): Yuko Fujita, Kenshi MakiSummaryIn recent decades, the eating habits of children and adolescents have undergone many changes due to the diversification of lifestyles worldwide. Reduced masticatory function in growing animals results in changes in the mandible, including a decrease in bone mass. However, the influence of different eating behaviors on jaw bone metabolism (e.g., the palatal palate) during the growth period is not fully understood. In addition, recent clinical studies reported that masticatory performance is posi...
Source: Japanese Dental Science Review - September 4, 2018 Category: Dentistry Source Type: research

Mastication as a tool to prevent cognitive dysfunctions
Publication date: Available online 31 August 2018Source: Japanese Dental Science ReviewAuthor(s): Gayathri Krishnamoorthy, Aparna I. Narayana, Dhanasekar BalkrishananSummaryMastication as we all know has always been related to its primary function of digestion, but little do we know that it produces an enhancing effect on general health, especially the cognitive performance related aspects of memory. Recent studies have shown its association with activation of various brain regions, however little is known about its effects on neuronal activity in these specified regions. According to the enormous evidences collected so fa...
Source: Japanese Dental Science Review - September 1, 2018 Category: Dentistry Source Type: research

Evidence-based strategy for dental biofilms: Current evidence of mouthwashes on dental biofilm and gingivitis
Publication date: Available online 31 August 2018Source: Japanese Dental Science ReviewAuthor(s): Shoji Takenaka, Tatsuya Ohsumi, Yuichiro NoiriSummaryTherapeutic mouthwash (MW) is an adjunctive tool along with a regular oral hygiene routine of daily tooth brushing and daily flossing. Previous systematic reviews have demonstrated that it is effective against dental biofilm and gingival inflammation, for prevention of dental caries, and for managing one’s bad breath condition according to the active ingredients. MWs prevent the microorganisms from bacterial adhesion that corresponds to the initial step in biofilm form...
Source: Japanese Dental Science Review - September 1, 2018 Category: Dentistry Source Type: research

Effects of blue-light irradiation during dental treatment
Publication date: Available online 31 August 2018Source: Japanese Dental Science ReviewAuthor(s): Fumihiko Yoshino, Ayaka YoshidaSummaryIn dentistry, blue light is widely used for tooth bleaching and restoration procedures involving composite resin. In addition, many dentists use magnification loupes to enable them to provide more accurate dental treatment. Therefore, the use of light is indispensable in dental treatment. However, light can cause various toxicities, and thermal injuries caused by light irradiation are regarded as particularly important. In recent years, the eye damage and non-thermal injuries caused by blu...
Source: Japanese Dental Science Review - September 1, 2018 Category: Dentistry Source Type: research

Structural features, processing mechanism and gene splice variants of dentin sialophosphoprotein
Publication date: Available online 25 August 2018Source: Japanese Dental Science ReviewAuthor(s): Yasuo Yamakoshi, James P. SimmerSummaryDentin sialophosphoprotein (DSPP) plays an important role in the formation of dentin. Understanding its structure and function would provide important insights into the regulation of dentin mineralization. For the past 15 years, we have been studying DSPP-derived proteins isolated from pig dentin. Porcine DSPP is synthesized and secreted by odontoblasts and processed into three proteins, i.e., dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP), by bone m...
Source: Japanese Dental Science Review - August 27, 2018 Category: Dentistry Source Type: research

Introduction to Kampo medicine for dental treatment — Oral pharmacotherapy that utilizes the advantages of Western and Kampo medicines
Publication date: Available online 25 August 2018Source: Japanese Dental Science ReviewAuthor(s): Pao-Li Wang, Akihiro KanekoSummaryKampo medicine is a medical system that has been systematically organized based on the reactions of the human body. At present, in Western, herbal medicines means the whole herbal product. It is being called Kampo medicine as a medicinal drug in Japan. Since 2012, the “National Health Insurance Drug Price Standards Related to Dental Treatment” published by the Japan Dental Association have included seven Kampo formulations. In 2015, the Japan Dental Association sent a “Kampo ...
Source: Japanese Dental Science Review - August 27, 2018 Category: Dentistry Source Type: research

Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Michiyo Matsumoto-NakanoSummaryStreptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to mo...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell–cell adhesion through N-cadherin
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Naoyuki Chosa, Akira IshisakiSummaryMesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC ther...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya LestariSummaryTooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odont...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Cancer metabolism: New insights into classic characteristics
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Yasumasa Kato, Toyonobu Maeda, Atsuko Suzuki, Yuh BabaSummaryInitial studies of cancer metabolism in the early 1920s found that cancer cells were phenotypically characterized by aerobic glycolysis, in that these cells favor glucose uptake and lactate production, even in the presence of oxygen. This property, called the Warburg effect, is considered a hallmark of cancer. The mechanism by which these cells acquire aerobic glycolysis has been uncovered. Acidic extracellular fluid, secreted by cancer cells, induces a malignant p...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

The shape of progress
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masahito Sumitomo (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Regulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Masanori Kashimata, Toru HayashiSummaryBranching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial–mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs)...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

The roles of odontoblasts in dental pulp innate immunity
Publication date: Available online 27 March 2018Source: Japanese Dental Science ReviewAuthor(s): Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi MatsuoSummaryOdontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external irritations. Therefore, odontoblasts possess a specialized innate immune system to fight oral pathogens invading into dentin. Generally, the rapid initial sensing of microbi...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery
This report presents an overview of currently available resorbable implant materials and their applications, with a focus on recent innovative advances and new developments in this field. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Uncovering the neural circuitry involved in the stress-attenuation effects of chewing
Publication date: Available online 6 April 2018Source: Japanese Dental Science ReviewAuthor(s): Kenichi Sasaguri, Kentaro Yamada, Toshiharu YamamotoAbstractPrevious animal studies have indicated that coupling restraint stress load with activation of the masticatory organs (chewing) causes a reduction in the systemic and central nervous system stress response. However, the brain mechanism underlying this effect is unknown. Therefore, in this review, we summarize the literature regarding brain regions involved in the attenuating effects of chewing and the systemic stress response attenuation effects induced by those brain re...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Wear of resin composites: Current insights into underlying mechanisms, evaluation methods and influential factors
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Akimasa Tsujimoto, Wayne W. Barkmeier, Nicholas G. Fischer, Kie Nojiri, Yuko Nagura, Toshiki Takamizawa, Mark A. Latta, Masashi MiazakiSummaryThe application of resin composites in dentistry has become increasingly widespread due to the increased aesthetic demands of patients, improvements in the formulation of resin composites, and the ability of these materials to bond to tooth structures, together with concerns about dental amalgam fillings. As resistance to wear is an important factor in determining the clinical success of re...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Implant treatment in ultra-aged society
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuji Sato, Noboru Kitagawa, Akio IsobeSummaryImplant therapy is gaining presence as a prosthodontic treatment option. However, the graying of the population has led to an increase in the number of older adults requiring special consideration in implant treatment because of their systemic health problems. Additionally, with the growth of the elderly population in need of long-term care, a greater number of older adults who have received implant treatment are receiving long-term care, raising various issues that need to be addresse...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Candida is a protractive factor of chronic oral ulcers among usual outpatients
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Haruhiko Terai, Takaaki Ueno, Yoshifumi Suwa, Michi Omori, Kayoko Yamamoto, Shin KasuyaSummaryAlthough many oral ulcers have similar clinical appearances, their etiologies can range from reactive to neoplastic to oral manifestations of dermatological diseases. In patients with an HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies of oral ulcerative lesions associated with Candida in patients without an HIV infection. Nevertheless, we encountered chronic oral ulcer associat...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Histological and immunological characteristics of the junctional epithelium
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Masanori NakamuraSummaryThe continuity of epithelial tissue is collapsed by tooth eruption. The junctional epithelium (JE) is attached to the tooth surface by hemidesmosomes, which constitutes the front-line defense against periodontal bacterial infection. JE constitutively expresses intercellular adhesion molecule-1 (ICAM-1), and neutrophils and lymphocytes penetrate into JE via interaction between ICAM-1 and LFA-1 expressed on the surface of these migrating cells. JE also expresses cytokines and chemokines. These functions of J...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Regulation of defensive function on gingival epithelial cells can prevent periodontal disease
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Tsuyoshi Fujita, Tetsuya Yoshimoto, Mikihito Kajiya, Kazuhisa Ouhara, Shinji Matsuda, Tasuku Takemura, Keiichi Akutagawa, Katsuhiro Takeda, Noriyoshi Mizuno, Hidemi KuriharaSummaryPeriodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacteri...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Molecularly-targeted therapy for the oral cancer stem cells
Publication date: May 2018Source: Japanese Dental Science Review, Volume 54, Issue 2Author(s): Yuichi Ohnishi, Hiroki Yasui, Masami Nozaki, Masahiro NakajimaSummaryHuman cancer tissues are heterogeneous in nature and become differentiated during expansion of cancer stem cells (CSCs). CSCs initiate tumorigenesis, and are involved in tumor recurrence and metastasis. Furthermore, data show that CSCs are highly resistant to anticancer drugs. Cetuximab, a specific anti-epidermal growth factor receptor (EGFR) monoclonal antibody, is used in cancer treatment. Although development of resistance to cetuximab is well recognized, the...
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Application of computer-assisted navigation systems in oral and maxillofacial surgery
This report presents an overview and feasible applications of available navigation systems with a focus on the clinical feasibility of the application of navigation systems in the field of oral and maxillofacial surgery and solutions to current problems. (Source: Japanese Dental Science Review)
Source: Japanese Dental Science Review - July 10, 2018 Category: Dentistry Source Type: research

Role of Streptococcus mutans surface proteins for biofilm formation
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Michiyo Matsumoto-NakanoSummaryStreptococcus mutans has been implicated as a primary causative agent of dental caries in humans. An important virulence property of the bacterium is its ability to form biofilm known as dental plaque on tooth surfaces. In addition, this organism also produces glucosyltransferases, multiple glucan-binding proteins, protein antigen c, and collagen-binding protein, surface proteins that coordinate to produce dental plaque, thus inducing dental caries. Bacteria utilize quorum-sensing systems to mo...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

Two novel mechanisms for maintenance of stemness in mesenchymal stem cells: SCRG1/BST1 axis and cell–cell adhesion through N-cadherin
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Naoyuki Chosa, Akira IshisakiSummaryMesenchymal stem cells (MSCs) retain the ability to self-renew and differentiate into mesenchymal cells. Therefore, human MSCs are suitable candidates for use in regenerative medicine and cell therapies. Upon activation by tissue damage, MSCs contribute to tissue repair through a multitude of processes such as self-renewal, migration, and differentiation. However, loss of self-renewal and multi-lineage differentiation potential occurs at a high rate during cell doubling. Effective MSC ther...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research

A review on non-syndromic tooth agenesis associated with PAX9 mutations
Publication date: February 2018Source: Japanese Dental Science Review, Volume 54, Issue 1Author(s): Nurul Hasyiqin Fauzi, Yunita Dewi Ardini, Zarina Zainuddin, Widya LestariSummaryTooth agenesis in the reduction of tooth number which includes hypodontia, oligodontia and anodontia is caused by disturbances and gene mutations that occur during odontogenesis. To date, several genetic mutations that unlock the causes of non-syndromic tooth agenesis are being discovered; these have been associated with certain illnesses because tooth development involves the interaction of several genes for tooth epithelium and mesenchyme odont...
Source: Japanese Dental Science Review - July 5, 2018 Category: Dentistry Source Type: research