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Source: Journal of Neurology, Neurosurgery and Psychiatry

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Total 415 results found since Jan 2013.

Seizures after decompressive hemicraniectomy for ischaemic stroke
Conclusions In this case series, patients were at high risk of developing seizures after malignant MCA stroke with DHC, especially after cranioplasty. Assuming these findings are replicated, means should be sought to reduce the occurrence of this complication.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 10, 2014 Category: Neurosurgery Authors: Creutzfeldt, C. J., Tirschwell, D. L., Kim, L. J., Schubert, G. B., Longstreth, W. T., Becker, K. J. Tags: Epilepsy and seizures, Stroke Cerebrovascular disease Source Type: research

Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial
Conclusions The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Arima, H., Anderson, C., Omae, T., Woodward, M., MacMahon, S., Mancia, G., Bousser, M.-G., Tzourio, C., Harrap, S., Liu, L., Neal, B., Chalmers, J., for the PROGRESS Collaborative Group Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Impact of anxiety on verbal and visuospatial working memory in patients with acute stroke without severe cognitive impairment
Conclusions In a stressful context, the contribution of state anxiety to reduced working memory performance is more pronounced in patients with acute stroke than in controls. These results are of particular relevance for clinicians assessing patients in the acute phase of stroke in which anxiety is highly prevalent.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2015 Category: Neurosurgery Authors: Grosdemange, A., Monfort, V., Richard, S., Toniolo, A.-M., Ducrocq, X., Bolmont, B. Tags: Stroke, Memory disorders (psychiatry) Cerebrovascular disease Source Type: research

Old benefit as much as young patients with stroke from high-intensity neurorehabilitation: cohort analysis
Conclusions Old and even very old patients with stroke benefit from specialised inpatient neurorehabilitation and high amounts of therapy in the same degree as younger patients. Contrary to current clinical practice, old age should not be a criterion against admission to a neurorehabilitation unit following acute stroke treatment.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 13, 2016 Category: Neurosurgery Authors: Knecht, S., Rossmüller, J., Unrath, M., Stephan, K.-M., Berger, K., Studer, B. Tags: Open access, Stroke Cerebrovascular disease Source Type: research

Predictive value of transcranial evoked potentials during mechanical endovascular therapy for acute ischaemic stroke: a feasibility study
Conclusions MEPs and SSEPs are safe and feasible methods of real-time monitoring of reperfusion success with respect to functional outcome during MET for acute ischaemic stroke.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Shiban, E., Wunderlich, S., Kreiser, K., Lehmberg, J., Hemmer, B., Prothmann, S., Zimmer, C., Meyer, B., Ringel, F. Tags: Immunology (including allergy), Stroke Cerebrovascular disease Source Type: research

The contribution of lesion location to upper limb deficit after stroke
Conclusions Quantification of structural damage can add to models explaining motor outcome after stroke, but assessment of corticospinal tract damage alone is unlikely to be sufficient when considering patients with stroke with a wide range of lesion topography.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2016 Category: Neurosurgery Authors: Park, C.-h., Kou, N., Ward, N. S. Tags: Open access, Stroke Cerebrovascular disease Source Type: research

Transcranial direct current stimulation for the treatment of post-stroke depression: results from a randomised, sham-controlled, double-blinded trial
Conclusions This was the first controlled study to demonstrate that tDCS was safe and effective for post-stroke depression. Therefore, tDCS might be a favourable option for treating these patients. Trial registration number NCT01525524; Results.
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 12, 2017 Category: Neurosurgery Authors: Valiengo, L. C. L., Goulart, A. C., de Oliveira, J. F., Bensenor, I. M., Lotufo, P. A., Brunoni, A. R. Tags: Long term care, Stroke, Mood disorders (including depression) Neuropsychiatry Source Type: research

Stroke paradox with SGLT-2 inhibitors: a play of chance or a viscosity-mediated reality?
Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. Current therapeutic strategies have not provided constant beneficial cardiovascular-related results. Sodium–glucose co-transporters 2 (SGLT-2) inhibitors have emerged as a novel antidiabetic class of drugs that exert favourable results in a variety of other cardiovascular risk factors too, such as increased blood pressure and body weight. The Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME) study was the first trial that evaluated cardiovascular outcomes in patients with diabetes with the us...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 16, 2017 Category: Neurosurgery Authors: Imprialos, K. P., Boutari, C., Stavropoulos, K., Doumas, M., Karagiannis, A. I. Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study
Conclusions These findings, described for the first time in a clinical cohort using whole brain CT perfusion and concomitant vascular imaging, suggest that age has a differential effect on acute tissue compartments in the wake of a preserved collateral vascular response and haemodynamic parameters. In agreement with the preclinical literature, the results point to a distinct tissue response to acute ischaemia in the ageing brain and merit validation studies in larger cohorts, particularly in relation to clinical outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Agarwal, S., Scoffings, D. J., Jones, P. S., Marrapu, S. T., Barry, P. J., O'Brien, E. W., Baron, J.-C., Warburton, E. A. Tags: Stroke, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Cerebral microbleeds and the risk of intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: systematic review and meta-analysis
Conclusions The available evidence does not demonstrate a statistically significant increased risk of symptomatic ICH after thrombolysis for ischaemic stroke in patients with CMBs. However, in view of the methodological limitations of the studies included, the clinical relevance of any potential hazard associated with CMBs remains uncertain. Further studies are warranted to evaluate whether the risk of ICH might outweigh the benefit of thrombolysis, especially in patients with multiple lobar CMBs suggestive of cerebral amyloid angiopathy.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Charidimou, A., Kakar, P., Fox, Z., Werring, D. J. Tags: Genetics, Stroke, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Polymorphisms of the serotonin transporter gene and post-stroke depression: a meta-analysis
Conclusions The 5-HTTLPR SS genotype may be a risk factor for PSD. The 5-HTTLPR LL genotype showed a significant negative association with PSD. Further research to assess the sensitivity and specificity of predicting the risk of developing PSD by screening for the 5-HTTLPR genotype in stroke patients is required.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Mak, K. K., Kong, W. Y., Mak, A., Sharma, V. K., Ho, R. C. M. Tags: Genetics, Long term care, Drugs: CNS (not psychiatric), Stroke Cerebrovascular disease Source Type: research

Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial
Conclusions GCS use declined dramatically following the reporting of the CLOTS-1 trial. The results support the notion that a neutral trial of a device can influence clinical practice rapidly, which is important with a widely used and moderately expensive (time and finance) intervention.
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Ankolekar, S., Renton, C., Bereczki, D., Sprigg, N., Payne, T., Gommans, J., Berge, E., Wardlaw, J., Dennis, M. S., Bath, P. M. W., for the ENOS Trial Investigators, Amarenco, Bath, Lees, Muir, Pocock, Shone, Sinclair, Venables, Wardlaw, Whynes, Bladin, C Tags: Drugs: CNS (not psychiatric), Stroke Cerebrovascular disease Source Type: research

Large ct perfusion-defined mismatch predicts early improvement after iv thrombolysis in acute ischaemic stroke
Conclusions Acute CTP mismatch ratio predicted early neurological improvement after IV rtPA treatment, with large mismatch ratios yielding better prediction of favourable early response. The combination of NIHSS and CTP mismatch may improve prediction of poor outcome. Since all patients received rtPA, no conclusion can be made about the interaction between imaging variables and rtPA.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Collins, P. D., Dani, K. A., Moreton, F., Huang, X., MacDougall, N. J., McVerry, F., Macleod, M. J., Wardlaw, J. M., Muir, K. W. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Diffusion mr correlates of motor function recovery after stroke: a systematic review
Conclusions FA is the most commonly measured metric but there was considerable heterogeneity in study design and analysis. Most studies were cross–sectional, confined to sub–cortical, ischaemic strokes at late stages, and involved younger patients than typical of the stroke population. Further evaluation of the utility of DTI as a biomarker for use in stroke recovery trials is needed.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Kalladka, D., Muir, K. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

The halifax acute stroke imaging study (hasis): does ct perfusion scanning in acute ischemic stroke predict final infarct volume?
Conclusions Results from HASIS suggest information from admission CTP and SI in suspected AIS patients can predict final infarct volume, where final volume of infarcted brain will not be smaller than that predicted by CTP CBV or CTA SI.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Langlands, G., Shankar, J., Simpkin, W., Christian, C., Phillips, S. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research