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Source: Journal of Neurology, Neurosurgery and Psychiatry

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Total 415 results found since Jan 2013.

Association of age with 1-year outcome in patients with acute ischaemic stroke treated with thrombectomy: real-world analysis in 18 506 patients
Conclusions In this large ‘real-world’ cohort, outcomes after mechanical thrombectomy were strongly associated with age. Of patients aged ≥80 years more than half were dead and less than one-fifth were functionally independent at 1 year. Certain comorbidities and ventilation >48 hours were associated with even worse outcomes.
Source: Journal of Neurology, Neurosurgery and Psychiatry - July 13, 2023 Category: Neurosurgery Authors: Beuker, C., Köppe, J., Feld, J., Meyer, C. L., Dröge, P., Ruhnke, T., Günster, C., Wiendl, H., Reinecke, H., Minnerup, J. Tags: Open access Cerebrovascular disease Source Type: research

Selecting stroke patients for thrombectomy: is CTA+ASPECTS enough?
Since 2014, a series of randomised controlled trails (RCTs) have demonstrated the benefit of endovascular thrombectomy (EVT) on functional outcome for the participants who had acute ischaemic stroke (AIS) with occlusion of a proximal intracranial artery in the anterior circulation. The characteristics of the people enrolled in these RCTs have been used to define recommended criteria to select patients for thrombectomy in clinical practice. The initial group of RCTs largely enrolled participants early after AIS (mostly under 6 hours) who had National Institutes of Health stroke scale scores ≥6 (range 0–42 with lowe...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Powers, W. Tags: Editorial commentaries Source Type: research

Endovascular treatment for large-core ischaemic stroke: a meta-analysis of randomised controlled clinical trials
Conclusion EVT appears to be effective and safe and may be considered for the treatment of large-core AIS, as assessed by ASPECTS of 2–5 or volumetric methods. PROSPERO registration number CRD42022334417.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 14, 2023 Category: Neurosurgery Authors: Palaiodimou, L., Sarraj, A., Safouris, A., Magoufis, G., Lemmens, R., Sandset, E. C., Turc, G., Psychogios, M., Tsivgoulis, G. Tags: Editor's choice Cerebrovascular disease Source Type: research

Clinical risk predictors for cerebral hyperperfusion syndrome after carotid endarterectomy
Conclusions Independent, prospective monitoring of a large cohort of CEA cases identified a brief time interval between ischaemic symptoms and endarterectomy as the clearest risk factor for CHS.
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 8, 2013 Category: Neurosurgery Authors: Maas, M. B., Kwolek, C. J., Hirsch, J. A., Jaff, M. R., Rordorf, G. A. Tags: Epilepsy and seizures, Headache (including migraine), Pain (neurology), Stroke, Hypertension, Ophthalmology, Ischaemic heart disease, Disability Neurosurgery Source Type: research

Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study
Conclusions EPVS are common in ICH. Different mechanisms may account for EPVS according to their anatomical distribution. Severe centrum semiovale EPVS may be secondary to, and indicative of, CAA with value as a new neuroimaging marker. By contrast, basal ganglia EPVS severity is associated with markers of hypertensive arteriopathy.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 7, 2013 Category: Neurosurgery Authors: Charidimou, A., Meegahage, R., Fox, Z., Peeters, A., Vandermeeren, Y., Laloux, P., Baron, J.-C., Jager, H. R., Werring, D. J. Tags: Genetics, Stroke, Hypertension Cerebrovascular disease Source Type: research

MRI in amyotrophic lateral sclerosis: more than a promise
In amyotrophic lateral sclerosis, the deadliest form of motor neuron diseases, physicians observe the spread of non-painful paralysis with intact sensory function often presenting as asymmetric muscle atrophy and brisk or maintained reflexes. Using Awaji criteria to estimate upper and lower motor neuron signs in bulbar, cervical, thoracic and lumbar regions, and the highly sensitive electromyography (EMG), they diagnose amyotrophic lateral sclerosis (ALS) in a majority of the cases. The spread of symptoms is attributed to spinal motor neuron pathology, but experienced ALS neurologists will agree that a slowing of movement,...
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 9, 2013 Category: Neurosurgery Authors: Grosskreutz, J. Tags: Dementia, Drugs: CNS (not psychiatric), Motor neurone disease, Neuromuscular disease, Spinal cord, Stroke, Memory disorders (psychiatry), Psychiatry of old age Editorial commentaries Source Type: research

Circulating endothelial cells as potential diagnostic biomarkers in primary central nervous system vasculitis
Conclusions For the first time it is shown that CEC are significantly elevated in patients with active PCNSV in contrast to other pathologies associated with brain infarction and correlate with disease activity. Sensitivity and specificity of the method for diagnosing PCNSV and the use of the method for treatment monitoring should be addressed in future prospective studies with a larger patient group.
Source: Journal of Neurology, Neurosurgery and Psychiatry - June 9, 2013 Category: Neurosurgery Authors: Deb, M., Gerdes, S., Heeren, M., Lambrecht, J., Worthmann, H., Goldbecker, A., Tryc, A. B., Lovric, S., Schulz-Schaeffer, W., Brandis, A., Dengler, R., Weissenborn, K., Haubitz, M. Tags: Immunology (including allergy), Stroke, Radiology, Vascularitis, Surgical diagnostic tests Cerebrovascular disease Source Type: research

Decompressive craniectomy in cerebral venous thrombosis: a single centre experience
Conclusions This is the largest series on decompressive craniectomy for CVT in literature to date. Decompressive craniotomy should be considered as a treatment option in large venous infarcts. Very good outcomes can be expected especially if done early and in those below 40 years.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 6, 2013 Category: Neurosurgery Authors: Aaron, S., Alexander, M., Moorthy, R. K., Mani, S., Mathew, V., Patil, A. K. B., Sivadasan, A., Nair, S., Joseph, M., Thomas, M., Prabhu, K., Joseph, B. V., Rajshekhar, V., Chacko, A. G. Tags: Stroke, Radiology, Radiology (diagnostics) Cerebrovascular disease Source Type: research

Cognitive domain deficits in patients with aneurysmal subarachnoid haemorrhage at 1 year
Background Cognitive domain deficits can occur after aneurysmal subarachnoid haemorrhage (aSAH) though few studies systemically evaluate its impact on 1-year outcomes. Objective We aimed to evaluate the pattern and functional outcome impact of cognitive domain deficits in aSAH patients at 1 year. Methods We carried out a prospective observational study in Hong Kong, during which, 168 aSAH patients (aged 21–75 years and had been admitted within 96 h of ictus) were recruited over a 26-month period. The cognitive function was assessed by a domain-specific neuropsychological assessment battery at 1 ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 6, 2013 Category: Neurosurgery Authors: Wong, G. K. C., Lam, S. W., Ngai, K., Wong, A., Siu, D., Poon, W. S., Mok, V., Cognitive Dysfunction after Aneurysmal Subarachnoid Hemorrhage Investigators, Kwok, Chan, Woo, Mak, Pang, Po, Chan, Wong, Lee, Wong, Lee, Ng, Wong, Pang Tags: Open access, Long term care, Stroke Cognitive neurology Source Type: research

Association between the rs1333040 polymorphism on the chromosomal 9p21 locus and sporadic brain arteriovenous malformations
Conclusions This is the first study demonstrating an association between an SNP of the 9p21 region and sporadic BAVMs. Our results emphasise the relevance of this chromosomal locus as a common risk factor for various forms of cerebrovascular diseases.
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 6, 2013 Category: Neurosurgery Authors: Sturiale, C. L., Gatto, I., Puca, A., D'Arrigo, S., Giarretta, I., Albanese, A., Di Rocco, C., Maira, G., Pola, R. Tags: Genetics, Epilepsy and seizures, Stroke Neurogenetics Source Type: research

Long term (13 years) prognosis after primary intracerebral haemorrhage: a prospective population based study of long term mortality, prognostic factors and causes of death
Conclusions One year survivors after ICH had a substantial and persisting excess mortality compared with the general population. Major causes of death were stroke and ischaemic heart disease.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 2, 2013 Category: Neurosurgery Authors: Hansen, B. M., Nilsson, O. G., Anderson, H., Norrving, B., Saveland, H., Lindgren, A. Tags: Stroke, Ischaemic heart disease Cerebrovascular disease Source Type: research

The tos study control data: how well do neurology in-patients recall being examined and does it matter?
Conclusions Although recall bias is a potential problem for the TOS score, this control data indicates that it should not be seen as a significant issue and does not negate the findings of our previous data collection that large numbers of in–patients with neurological problems are not been appropriately examined. TOS scores provide a method of quantifying the thoroughness of neurological examination and we are at present in the process of organising a multicentre study in six countries using TOS scores to establish how widespread this problem is globally.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Mulla, A., Appleton, J., Nicholl, D. Tags: Headache (including migraine), Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Crossed cerebellar diaschisis: a radiological finding in status epilepticus not to miss
We report a case of status epilepticus with initial MRI findings consistent with Crossed Cerebellar Diaschisis.The abnormalities resolved on successful treatment but subsequently recurred during a second episode of complex partial status epilepticus. We will discuss the images and pathophysiology of crossed Cerebellar diaschisis in status epilepticus.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Zaidi, S. Tags: Brain stem / cerebellum, Epilepsy and seizures, Stroke Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

The medical research council neuromuscular centre for translational research mitochondrial disease patient cohort study uk: from conceptualisation to utilisation
Conclusion For the first time in the UK it is possible to access a large cohort of well–characterised patients with mitochondrial disease. The cohort provides objective data on mitochondrial disease progression, in children and adults, allowing evidence–based guidelines to be developed, and prognostic advice to be provided to patients and families. There is a vast amount of data still to be analysed that will provide systematic evidence and allow the development of disease prevention strategies.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Nesbitt, V., Pitceathly, R., Cockell, S., Poulton, J., Rahman, S., Hanna, M., Taylor, R., Chinnery, P., Turnbull, D., McFarland, R. Tags: Genetics, Epilepsy and seizures, Headache (including migraine), Muscle disease, Neuromuscular disease, Stroke, Musculoskeletal syndromes Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 Oc Source Type: research

Reversible leukoencephalopathy as a presentation of cerebral amyloid angiopathy
A 73 year old man with a past medical history of hypertension, osteoathritis and asthma presented to the local district general hospital with recurrent episodes of spontaneously resolving encephalopathy. The initial presentation was characterised by acute confusion and visual hallucinations followed by a generalised tonic–clonic seizure. On examination his blood pressure was 215/115 mmHg. Neurological examination did not reveal any lateralising signs but the patient was found to be encephalopathic with a Montreal Cognitive Assessment (MOCA) score of 9/30. Routine blood tests were unremarkable. A CT brain scan showed ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Vassallo, J., Punter, M. Tags: Genetics, Immunology (including allergy), Epilepsy and seizures, Stroke, Hypertension, Drugs: psychiatry, Radiology, Surgical diagnostic tests Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23 Source Type: research