Effect of the neutral CLOTS 1 trial on the use of graduated compression stockings in the Efficacy of Nitric Oxide Stroke (ENOS) trial

Conclusions
GCS use declined dramatically following the reporting of the CLOTS-1 trial. The results support the notion that a neutral trial of a device can influence clinical practice rapidly, which is important with a widely used and moderately expensive (time and finance) intervention.

Source: Journal of Neurology, Neurosurgery and Psychiatry - February 15, 2013 Category: Neurosurgery Authors: Ankolekar, S., Renton, C., Bereczki, D., Sprigg, N., Payne, T., Gommans, J., Berge, E., Wardlaw, J., Dennis, M. S., Bath, P. M. W., for the ENOS Trial Investigators, Amarenco, Bath, Lees, Muir, Pocock, Shone, Sinclair, Venables, Wardlaw, Whynes, Bladin, C Tags: Drugs: CNS (not psychiatric), Stroke Cerebrovascular disease Source Type: research