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Condition: Hemorrhagic Stroke
Education: Learning
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Total 196 results found since Jan 2013.
Isolated middle cerebral artery dissection: a systematic review
Abstract
Acute stroke can be missed in the emergency department, particularly in younger patients and in those with more vague symptoms such as headache or dizziness. Cervicocephalic dissections are one group of etiologies for acute stroke in the young. While cervicocephalic dissections are not uncommon in clinical practice, isolated middle cerebral artery dissection (MCAD) has been rarely reported as a cause for stroke. We sought to review the clinical implications and pathophysiology of an isolated MCAD. We searched the medical literature for isolated MCAD in clinical stroke patients using MEDLINE, HighWire, an...
Source: International Journal of Emergency Medicine - December 17, 2014 Category: Emergency Medicine Source Type: research
Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation.
CONCLUSIONS: -By identifying known drugs as potential therapeutics for CCM, we have decreased the time, cost, and risk of bringing treatments to patients. Each drug also prompts additional exploration of biomarkers of CCM disease. We further suggest that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease.
PMID: 25486933 [PubMed - as supplied by publisher]
Source: Circulation - December 8, 2014 Category: Cardiology Authors: Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY Tags: Circulation Source Type: research
Microwave-Based Stroke Diagnosis Making Global Prehospital Thrombolytic Treatment Possible
Here, we present two different brain diagnostic devices based on microwave technology and the associated two first proof-of-principle measurements that show that the systems can differentiate hemorrhagic from ischemic stroke in acute stroke patients, as well as differentiate hemorrhagic patients from healthy volunteers. The system was based on microwave scattering measurements with an antenna system worn on the head. Measurement data were analyzed with a machine-learning algorithm that is based on training using data from patients with a known condition. Computer tomography images were used as reference. The detection meth...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research
Ctbrain machine learning predicts stroke thrombolysis result
Conclusions
This proof-of-concept study shows that machine learning methods applied to acute stroke CT-scans potentially offers automation, and improved performance in SICH prediction following thrombolysis. Larger-scale cohorts, and incorporation of CT perfusion/angiography data, should be tested with such methods.
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Epton, S., Bentley, P., Ganesalingam, J., Dias, A., Mahady, K., Rinne, P., Sharma, P., Halse, O., Mehta, A., Rueckert, D. Tags: Abstracts Source Type: research
Single-Center Experience and Short-term Outcome With the JenaValve: A Second-Generation Transapical Transcatheter Aortic Valve Implantation Device
ConclusionsThis second-generation repositionable transcatheter aortic valve implantation device could safely and successfully be implanted with a fast learning curve, significant reduction in pressure gradients, overall clinical improvement at discharge, as well as an acceptable morbidity and mortality rate in this highest-risk patient cohort.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - September 1, 2014 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research
'Safe' stem cell therapy may help stroke recovery
Conclusion
This study provides evidence that a new technique using a patient's own stem cells to aid the recovery from severe ischaemic stoke is feasible and appears to be safe. It was not designed to test whether the technique was better than doing nothing or better than other types of care or treatment.
The authors are perfectly clear that this "proof-of-concept study was not designed with a control group or powered to be able to detect efficacy". This means we cannot be sure that the improvements seen in the five patients were caused by the stem cell treatment. They could have occurred anyway as part of the na...
Source: NHS News Feed - August 11, 2014 Category: Consumer Health News Tags: Genetics/stem cells Heart/lungs Source Type: news
Hyperbaric oxygen therapy fails to reduce hydrocephalus formation following subarachnoid hemorrhage in rats
Conclusion
Multiple HBO therapy does not ameliorate hydrocephalus formation in a rat model of SAH; however, HBO tendentially improved the neurological functions and spatial learning and memory abilities in rats with hydrocephalus.
Source: Medical Gas Research - July 9, 2014 Category: Biomedical Science Source Type: research
Do No Harm: Stories of Life, Death and Brain Surgery review
Patients see neurosurgeons as gods, but what is the reality? Henry Marsh has written a memoir of startling candourWe go to doctors for help and healing; we don't expect them to make us worse. Most people know the aphorism taught to medical students, attributed to the ancient Greek Hippocrates but timeless in its quiet sanity: "First, do no harm." But many medical treatments do cause harm: learning how to navigate the risks of drug therapies, as well as the catastrophic consequences of botched or inadvised surgical operations, is a big part of why training doctors takes so long. Even the simplest of therapies carries the ri...
Source: Guardian Unlimited Science - March 19, 2014 Category: Science Authors: Gavin Francis Tags: The Guardian Private healthcare Culture Society Reviews Books Neuroscience UK news Hospitals NHS Source Type: news
Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage Basic Sciences
Conclusions—
Sur1-Trpm4 channels are upregulated in humans and rats with SAH. Channel inhibition with glibenclamide may reduce neuroinflammation and the severity of cognitive deficits after SAH.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Tosun, C., Kurland, D. B., Mehta, R., Castellani, R. J., deJong, J. L., Kwon, M. S., Woo, S. K., Gerzanich, V., Simard, J. M. Tags: Basic Sciences Source Type: research
Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms
Trauma patients with "compensated" internal hemorrhage may not be identified with standard medical monitors until signs of shock appear, at which point it may be difficult or too late to pursue life-saving interventions. We tested the hypothesis that a novel machine-learning model called the compensatory reserve index (CRI) could differentiate tolerance to acute volume loss of individuals well in advance of changes in stroke volume (SV) or standard vital signs. Two hundred one healthy humans underwent progressive lower body negative pressure (LBNP) until the onset of hemodynamic instability (decompensation). Continuously m...
Source: Journal of Applied Physiology - October 15, 2013 Category: Physiology Authors: Convertino, V. A., Grudic, G., Mulligan, J., Moulton, S. Tags: INNOVATIVE METHODOLOGIES Source Type: research
337-i * thoracoscopic left atrial appendectomy
Conclusions: This approach demonstrated feasibility, safety and effectiveness and should be considered as a possible alternative to percutaneous closure of the LAA. However, its effect on long-term prevention of stroke needs to be evaluated.
Source: Interactive CardioVascular and Thoracic Surgery - September 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Guerra, M., Miranda, J., Martins, D., Neves, P., Gama, V., Vouga, L. Tags: Learning from experience (film) Source Type: research
Closed-Loop Fluid Administration Compared to Anesthesiologist Management for Hemodynamic Optimization and Resuscitation During Surgery: An In Vivo Study.
CONCLUSION:This in vivo study building on previous simulation work demonstrates that the closed-loop fluid management system used in this experiment can perform fluid resuscitation during mild and severe hemorrhages and is able to maintain high cardiac output and stroke volume while reducing hemodynamic variability.
PMID: 23835453 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - July 8, 2013 Category: Anesthesiology Authors: Rinehart J, Lee C, Canales C, Kong A, Kain Z, Cannesson M Tags: Anesth Analg Source Type: research
Prenatal cerebrovascular accidents diagnosed in the early infant stage: a series of 10 patients.
CONCLUSIONS. When CVA are not detected in the prenatal period, it is important in primary care to look for and detect the warning signs of the psychomotor development of the infant at an early stage in order to begin a study of the case and to undertake rehabilitation as early as possible.
PMID: 23799595 [PubMed - in process]
Source: Revista de Neurologia - July 1, 2013 Category: Neurology Authors: Pina-Jover M, Martinez-Del Villar M, Lillo-Laguna L, Jadraque-Rodriguez R, Martinez-Pastor P, Jover-Cerda J, Gomez-Gosalvez F Tags: Rev Neurol Source Type: research
Posterior Fossa Syndrome After Cerebellar Stroke.
We report longitudinal clinical, neurocognitive and neuroradiological findings in a 71-year-old right-handed patient who developed PFS following a right cerebellar haemorrhage that was not surgically evacuated. During follow-up, functional neuroimaging was conducted by means of quantified Tc-99m-ECD SPECT studies. After a 10-day period of akinetic mutism, the clinical picture developed into cerebellar cognitive affective syndrome (CCAS) with reversion to a previously learnt accent, consistent with neurogenic foreign accent syndrome (FAS). No psychometric evidence for dementia was found. Quantified Tc-99m-ECD SPECT studies ...
Source: Cerebellum - April 11, 2013 Category: Neuroscience Authors: Mariën P, Verslegers L, Moens M, Dua G, Herregods P, Verhoeven J Tags: Cerebellum Source Type: research
Towards robust deconvolution of low-dose perfusion CT: Sparse perfusion deconvolution using online dictionary learning
Graphical abstract: Highlights: ► Dictionaries are learned from high-dose CTP data for low-dose CBF estimation. ► Temporal convolution model is combined with spatial dictionary mapping prior. ► Evaluation on in vivo aneurysmal subarachnoid hemorrhage and normal patients. ► Outperform existing methods in CBF estimation for low-dose CTP data. ► Improve the differentiation between ischemic and normal tissues in the brain.Abstract: Computed tomography perfusion (CTP) is an important functional imaging modality in the evaluation of cerebrovascular diseases, particularly in acute stroke and vasospasm. However, the post...
Source: Medical Image Analysis - March 7, 2013 Category: Radiology Authors: Ruogu Fang, Tsuhan Chen, Pina C. Sanelli Source Type: research
