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Total 3622 results found since Jan 2013.

Stroke Volume Predicts Nocturnal Hypoxemia in the Acute Ischemic Stroke after Intravenous Thrombolysis
The Goal: The aim of the study was to investigate whether stroke volume or the presence of ischemic stroke lesion on follow-up computed tomography 1 day after admission had association with sleep apnea among ischemic stroke patients undergoing thrombolysis. Materials and Methods: We prospectively recruited 110 consecutive ischemic stroke patients and performed computed tomography on admission and after 24 hours after intravenous thrombolysis. Stroke volume was measured from post-thrombolysis computed tomography scans.
Source: Journal of Stroke and Cerebrovascular Diseases - July 1, 2019 Category: Neurology Authors: Jaana K. Huhtakangas, Tarja Saaresranta, Michaela K. Bode, Risto Bloigu, Juha Huhtakangas Source Type: research

Clozapine-Induced Chemogenetic Neuromodulation Rescues Post-Stroke Deficits After Chronic Capsular Infarct
AbstractLong-term disabilities induced by stroke impose a heavy burden on patients, families, caregivers, and public health systems. Extensive studies have demonstrated the therapeutic value of neuromodulation in enhancing post-stroke recovery. Among them, chemogenetic neuromodulation activated by clozapine-N-oxide (CNO) has been proposed as the potential tool of neuromodulation. However, recent evidence showed that CNO does not cross the blood  − brain barrier and may in fact have low binding affinity for chemogenetic tool. Thus, clozapine (CLZ) has been suggested for use in chemogenetic neuromodulation, in place of...
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research

The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Frank A. Wollenweber, Vera Zietemann, Axel Rominger, Christian Opherk, Anna Bayer‐Karpinska, Andreas Gschwendtner, Lisa Coloma Andrews, Katharina Bürger, Marco Duering, Martin Dichgans Tags: Protocols Source Type: research

The CLOQS trial protocol: a cluster‐randomized trial evaluating a simple, low‐cost intervention to reduce treatment times in acute stroke
The objective of the Countdown Lights to Optimize Quality in acute Stroke (CLOQS) trial is to determine whether a simple, low‐cost organizational behavior intervention, a large, red stopwatch timer attached to the stretcher upon arrival, will decrease door‐to‐scanner and door‐to‐needle treatment times for tissue plasminogen activator‐treated patients. DesignA multicenter, time‐clustered randomized control trial. The stopwatch timers will be used in Emergency Departments for all acute stroke patients across the University of Toronto Stroke Program. The order of intervention (ON) and control (OFF) blocks will b...
Source: International Journal of Stroke - September 5, 2013 Category: Neurology Authors: Richard H. Swartz, Michelle N. Sicard, Frank L. Silver, Gustavo Saposnik, David J. Gladstone, Jennifer Breaton, Sharon Ramagnano, Jacques Lee, Richard I. Aviv, Jiming Fang, Merrick F. Zwarenstein, Tags: Protocols Source Type: research

Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: studies in a rat stroke model
ConclusionsThe data provide perfusion computed tomography defined relative cerebral blood flow thresholds for infarct core and ischemic penumbra within the first two hours after experimental stroke in rats. These thresholds were shown to be stable to define the volume of infarct core and penumbra within this time window.
Source: International Journal of Stroke - October 21, 2013 Category: Neurology Authors: D. D. McLeod, M. W. Parsons, R. Hood, B. Hiles, J. Allen, S. K. McCann, L. Murtha, M. B. Calford, C. R. Levi, N. J. Spratt Tags: Research Source Type: research

Mechanism of Acute Ischemic Stroke in Patients with Severe Middle Cerebral Artery Atherosclerotic Disease
Conclusions: In patients with severe MCA ICAD, the mechanism of stroke is multifactorial, but hemodynamic insufficiency plays a significant role. This finding is important in selecting a subgroup of patients who may benefit from revascularization.
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2014 Category: Neurology Authors: Jordan S. Dubow, Elliott Salamon, Edward Greenberg, Athos Patsalides Tags: Original Articles Source Type: research

Sensitivity and Specificity of the Hyperdense Artery Sign for Arterial Obstruction in Acute Ischemic Stroke Clinical Sciences
Conclusions— When present in acute ischemic stroke, HAS indicates a high likelihood of arterial obstruction, but its absence indicates only a 50/50 chance of normal arterial patency. Thin-slice CT improves sensitivity of HAS detection. Clinical Trial Registration— URL: http://www.controlled-trials.com/ISRCTN25765518. Unique identifier: ISRCTN25765518.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Mair, G., Boyd, E. V., Chappell, F. M., von Kummer, R., Lindley, R. I., Sandercock, P., Wardlaw, J. M., IST-3 Collaborative Group Tags: Arterial thrombosis, Acute Cerebral Infarction, Angiography Clinical Sciences Source Type: research

Magnetic Resonance Imaging in Experimental Stroke and Comparison With Histology: Systematic Review and Meta-Analysis Basic Sciences
Conclusions— Guidelines for standardized use and reporting of MRI in preclinical stroke are urgently needed. T2-weighted imaging could be used as an effective in vivo alternative to histology for estimating treatment effects based on the extent of infarction; however, additional studies are needed to explore the effect of individual parameters.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Milidonis, X., Marshall, I., Macleod, M. R., Sena, E. S. Tags: Acute Cerebral Infarction, Computerized tomography and Magnetic Resonance Imaging Basic Sciences Source Type: research

Embolic Stroke of Undetermined Source (ESUS): A single center study from Argentina (P1.060)
CONCLUSIONS: Even with complete work-up, upon initial assessment more than one third of ischemic stroke patients met criteria for ESUS. After one year follow-up, it is possible to reclassify some of them, mostly as cardioembolic. More studies are needed to establish unidentified etiologies and the effect of longer follow-ups. Study Supported by:Disclosure: Dr. Pertierra has nothing to disclose. Dr. Hawkes has nothing to disclose. Dr. Farez has received personal compensation for activities with Merck Serono. Dr. Gomez-Scheneider has nothing to disclose. Dr. Pastor-Rueda has nothing to disclose. Dr. Calandri has nothing to d...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Pertierra, L., Hawkes, M., Farez, M., Gomez-Scheneider, M., Pastor-Rueda, J., Calandri, I., Pujol-Lereis, V., Ameriso, S. Tags: Cerebrovascular Disease and Interventional Neurology: Atrial Fibrillation and Cardio-embolic Stroke Source Type: research

Adding transcutaneous electrical nerve stimulation to visual scanning training does not enhance treatment effect on hemispatial neglect: a randomized, controlled, double-blind study.
CONCLUSION: Our study did not provide evidence of the effectiveness of TENS when added to VST during early rehabilitation for patients with post-stroke hemispatial neglect. Other techniques (applied alone or together) should be sought to improve recovery in this population. PMID: 26431365 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 2, 2015 Category: Neurology Authors: Seniów J, Polanowska K, Leśniak M, Członkowska A Tags: Top Stroke Rehabil Source Type: research

Overcoming Barriers to Reduce Door to Needle Times in Acute Ischemic Stroke Patients: Field to CT (I6.011)
CONCLUSION: Taking patients Direct to CT has significantly reduced time to evaluation, DTCT, and DTN.. Numerous barriers to Direct to CT were identified at the pre-hospital, ED, CT and stroke team levels. Some of these concerns are ongoing and will take time and effort to overcome. Strengths noted were the EMS capability of pre-hospital Intravenous line establishment, blood draws, and EKG performance as well as IV tPA initiation in the CT area.Disclosure: Dr. Panezai has nothing to disclose. Dr. Chukwuneke has nothing to disclose. Dr. Arango has nothing to disclose. Dr. Brar has nothing to disclose. Dr. Daniel has nothing ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Panezai, S., Chukwuneke, F., Arango, A., Brar, J., Daniel, J., Korya, D., Mehta, S., Moussavi, M., Kirmani, J. Tags: Future Directions and Challenges in Stroke Team Action Therapy (STAT) Poster Presentations Source Type: research

Stroke vision, aphasia, neglect (VAN) assessment--a novel emergent large vessel occlusion screening tool: pilot study and comparison with current clinical severity indices
Conclusions The VAN screening tool accurately identified ELVO patients and outperformed a NIHSS ≥6 severity threshold and may best allow clinical teams to expedite care and mobilize resources for ELVO patients. A larger study to both validate this screening tool and compare with others is warranted.
Source: Journal of NeuroInterventional Surgery - January 12, 2017 Category: Neurosurgery Authors: Teleb, M. S., Ver Hage, A., Carter, J., Jayaraman, M. V., McTaggart, R. A. Tags: Open access, Ischemic stroke Source Type: research

Pulmonary embolism in acute ischaemic stroke (p4.293)
Conclusions:PE was observed in 0.32% of AIS and associated with high rates of death and disability. CTA stroke protocol images from aortic arch to vertex allows visualization of upper pulmonary arteries and detection PE in AIS.Disclosure: Dr. Eswaradass has nothing to disclose. Dr. Dey has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Hill has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Eswaradass, P. V., Dey, S., Singh, D., Hill, M. Tags: In-Hospital Stroke Care Source Type: research

Predicting brain atrophy from resting-state functional connectivity and structural connectivity in ischemic stroke (P5.297)
Conclusions:Resting-state functional connectivity with the lesion location can predict atrophy of remote brain regions after ischemic stroke, independent of structural white-matter connectivity.Study Supported by: M.D.F. was supported by the National Institutes of Health (R21 MH099196, K23 NS083741), Dystonia Medical Research Foundation, National Parkinson’s Foundation, and NFL Players Association. A.J. was supported by a Postdoctoral Fellowship from the Natural Sciences and Engineering Research Council of Canada (NSERC PDF 454617). A.D.B. was supported by 4K12HD027748-24.Disclosure: Dr. Jannati has nothing to disclo...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Jannati, A., Boes, A. D., Horn, A., Pascual-Leone, A., Kuceyeski, A., Fox, M. D. Tags: Stroke Recovery and Rehabilitation Source Type: research

Saving Vanessa, part 1: A mystery rash, a stroke and an epic rescue
Vanessa’s rash first appeared on her arms and legs when she 3 or 4 months old. It was red and bumpy and went away when she was sick with a virus, which happened often. Then it would come back. The dermatology team she saw at Boston Children’s Hospital was puzzled. “I was expecting they were going to think it was nothing, but they took it very seriously,” says Katherine Bell, one of Vanessa’s mothers. “They took a biopsy and very quickly realized they had no idea what it was.” Vanessa’s case was even featured at a regional dermatology conference where doctors take up mystery patients. “A hundred to 150 der...
Source: Thrive, Children's Hospital Boston - July 25, 2017 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Our Patients’ Stories Dr. Carolyn Rogers Dr. Pui Lee Dr. Robert Sundel Dr. Scellig Stone Dr. Todd Lyons stroke Source Type: news