Filtered By:
Education: Study
Procedure: Anesthesia

This page shows you your search results in order of relevance. This is page number 2.

Order by Relevance | Date

Total 2417 results found since Jan 2013.

Hemodynamics during anesthesia for intra-arterial therapy of acute ischemic stroke
Conclusions Patients with acute ischemic stroke undergoing intra-arterial therapy with general anesthesia had lower minimum SBP, DBP, and MAP, greater fluctuations in blood pressure, and less favorable outcomes. More studies are needed to examine the implications of variable and reduced blood pressures and neurological outcomes.
Source: Journal of NeuroInterventional Surgery - August 11, 2016 Category: Neurosurgery Authors: Jagani, M., Brinjikji, W., Rabinstein, A. A., Pasternak, J. J., Kallmes, D. F. Tags: Ischemic stroke Source Type: research

Anesthesia and neurologic outcome of endovascular therapy in acute ischemic stroke: MR (not so) CLEAN
Recent trials have confirmed the effectiveness of endovascular mechanical thrombectomy for selected acute ischemic stroke patients with large artery occlusion, whose outcomes remained poor despite optimal medical management. Among many challenges for thrombectomy implementation is determining whether general anesthesia (GA) reduces the benefits of thrombectomy, as several recent studies suggest.1,2 Berkhemer et al.3 approach this question with a post hoc analysis of Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), the first prospective, randomized stud...
Source: Neurology - August 14, 2016 Category: Neurology Authors: Crosby, G., Muir, K. W. Tags: Stroke prevention, Infarction EDITORIALS Source Type: research

Monitored anesthesia care during mechanical thrombectomy for stroke: need for data-driven and individualized decisions
Conclusions Our study showed that the overall rate of conversion from MAC to GA during MT was low (1.6%) and, while higher in posterior circulation strokes, it was not predicted by either hemispheric dominance or stroke severity. Caution should be given before changing clinical practice during moments of crisis.
Source: Journal of NeuroInterventional Surgery - November 18, 2021 Category: Neurosurgery Authors: Nogueira, R. G., Mohammaden, M. H., Moran, T. P., Whalin, M. K., Gershon, R. Y., Al-Bayati, A. R. R., Ratcliff, J., Pisani, L., Liberato, B., Bhatt, N., Frankel, M. R., Haussen, D. C. Tags: Ischemic stroke, COVID-19 Source Type: research

The effect of anesthetic management during intra-arterial therapy for acute stroke in MR CLEAN
Conclusions: In this post hoc analysis, we found that the type of anesthetic management influences outcome following IAT. Only treatment without general anesthesia was associated with a significant treatment benefit in MR CLEAN. Classification of evidence: This study provides Class II evidence that for patients with acute ischemic stroke undergoing IAT, mRS scores at 90 days improve only in patients treated without GA.
Source: Neurology - August 14, 2016 Category: Neurology Authors: Berkhemer, O. A., van den Berg, L. A., Fransen, P. S. S., Beumer, D., Yoo, A. J., Lingsma, H. F., Schonewille, W. J., van den Berg, R., Wermer, M. J. H., Boiten, J., Lycklama a Nijeholt, G. J., Nederkoorn, P. J., Hollmann, M. W., van Zwam, W. H., van der Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Embolism, Infarction ARTICLE Source Type: research

Pulmonary and circulatory parameter guided anesthesia in patients with ischemic stroke undergoing endovascular recanalization
Conclusions In patients receiving endovascular stroke treatment under general anesthesia, the cumulative dose of norepinephrine was an independent predictor of an unfavorable outcome. Further studies are needed to evaluate the optimal management of blood pressure in these patients, and whether avoidance of catecholamines could partly explain the improved outcomes for patients treated under conscious sedation in retrospective studies.
Source: Journal of NeuroInterventional Surgery - March 15, 2016 Category: Neurosurgery Authors: Mundiyanapurath, S., Stehr, A., Wolf, M., Kieser, M., Möhlenbruch, M., Bendszus, M., Hacke, W., Bösel, J. Tags: Ischemic stroke Source Type: research

Rescue carotid puncture for ischemic stroke treated by endovascular therapy: a multicentric analysis and systematic review
Conclusion RCP mainly concerned elderly patients admitted for AIS with anterior LVO with supra-aortic tortuosity. The procedure seemed feasible, notably for patients treated with IVT, and led to significant reperfusion rates at the end of procedure, but with pronounced unfavorable outcomes at 3 months. RCP should be performed under general anesthesia to avoid life-threatening complications and ensure airways safety. Finally, RCP led to low rates of closure complications, emphasizing that this concern should not withhold RCP, if indicated.
Source: Journal of NeuroInterventional Surgery - August 13, 2021 Category: Neurosurgery Authors: Allard, J., Ghazanfari, S., Mahmoudi, M., Labreuche, J., Escalard, S., Delvoye, F., Ciccio, G., Smajda, S., Redjem, H., Hebert, S., Consoli, A., Costalat, V., Desilles, J.-P., Mazighi, M., Piotin, M., Dargazanli, C., Lapergue, B., Blanc, R., Maïer Tags: Ischemic stroke Source Type: research

Circulatory and Respiratory Parameters during Acute Endovascular Stroke Therapy in Conscious Sedation or General Anesthesia
Whether patients suffering from acute ischemic stroke and undergoing endovascular recanalization should be treated under general anesthesia (GA) or conscious sedation (CS) is a matter of debate. According to retrospective studies, GA appears to be associated with a worse outcome than CS. The underlying mechanisms are unknown, but hypotension and hypocapnia during GA have been suggested. There are no prospective data on this question.
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2015 Category: Neurology Authors: Sibu Mundiyanapurath, Silvia Schönenberger, Maritoni L. Rosales, Ana M. Carrilho Romeiro, Markus Möhlenbruch, Martin Bendszus, Werner Hacke, Julian Bösel Source Type: research

Local anesthesia as a distinct comparator versus conscious sedation and general anesthesia in endovascular stroke treatment: a systematic review and meta-analysis
Conclusion LA without sedation was not significantly superior to CS or GA in improving outcomes when performing EVT for AIS. However, the quality of the included studies impaired interpretation, and inclusion of an LA arm in future well designed multicenter, randomized controlled trials is warranted.
Source: Journal of NeuroInterventional Surgery - February 16, 2022 Category: Neurosurgery Authors: Butt, W., Dhillon, P. S., Podlasek, A., Malik, L., Nair, S., Hewson, D., England, T. J., Lenthall, R., McConachie, N. Tags: Ischemic stroke Source Type: research

General anesthesia during endovascular therapy for acute ischemic stroke: benefits beyond better reperfusion?
Conclusion The better outcome after EVT in the GA arm was mainly a direct effect—that is, an effect that was not explained by better reperfusion. We also found a better outcome in the GA arm when reperfusion was not achieved. Whether this is an effect of the stable condition and blood pressure under GA or a neuroprotective effect will need to be investigated in future research.
Source: Journal of NeuroInterventional Surgery - July 14, 2022 Category: Neurosurgery Authors: Simonsen, C. Z., Rasmussen, M., Schönenberger, S., Henden, P. L., Bösel, J., Valentin, J. B. Tags: Ischemic stroke Source Type: research

Cell-Based Therapies for Stroke: Promising Solution or Dead End? Mesenchymal Stem Cells and Comorbidities in Preclinical Stroke Research
Conclusion The high prevalence of comorbidities in patients with stroke indicates the need for therapies in preclinical studies that take into account these comorbidities in order to avoid failures in translation to the patient. Preclinical studies are beginning to evaluate the efficacy of MSC treatment in stroke associated with comorbidities, especially hypertension, for ischemic and hemorrhagic stroke. Regarding aging and diabetes, only ischemic stroke studies have been performed. For the moment, few studies have been performed and contradictory results are being reported. These contradictory results may be due to the u...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

Combining Human Umbilical Cord Blood Cells With Erythropoietin Enhances Angiogenesis/Neurogenesis and Behavioral Recovery After Stroke
In conclusion, our results suggest that hUCBC infusion in combination with EPO administration demonstrates therapeutic efficacy in the treatment of stroke-induced injury by promoting neurogenesis and angiogenesis. Further research that delineates the therapeutic mechanism of systemically administered hUCBC and EPO is required. Ethics Statement All experimental procedures involving animals were performed in accordance with the Guide for the Care and Use of Laboratory Animals as adopted and promulgated by the U. S. National Institutes of Health and were approved by CHA University Institutional Animal Care & Use Com...
Source: Frontiers in Neurology - April 9, 2019 Category: Neurology Source Type: research

Acupuncture for Post-stroke Shoulder-Hand Syndrome: A Systematic Review and Meta-Analysis
Conclusions: Acupuncture therapy seems effective for motor function, pain relief and activities of daily living in stroke patients with mild SHS, when it is used in combination with rehabilitation. The low certainty of evidence downgrades our confidence in making recommendations to clinical practice. Introduction Shoulder-hand syndrome (SHS) is a common condition among people who have had a stroke, with its reported prevalence ranging from 12% to 49% (1, 2). The main symptoms of SHS include pain, hyperalgesia, joint swelling and limitations in range of motion (ROM) (3). Post-stroke SHS is also named type I complex ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research