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A typology of cerebral small vessel disease based on imaging markers
ConclusionThe study confirmed the existence of different SVD types with different relationships to stroke outcome. EPVS and WMH were identified as imaging features of presumably early progression. The number of microbleeds and WMH severity appear to be promising biomarkers for distinguishing clinical subgroups. Further understanding of SVD progression might require consideration of refined SVD features, e.g., for EPVS and type of lacunes.
Source: Journal of Neurology - September 20, 2023 Category: Neurology Source Type: research
NIH researchers develop new method to identify potential stroke therapies
First-of-its-kind study points to uric acid as a promising treatment for further investigation.
Source: National Institutes of Health (NIH) News Releases - September 20, 2023 Category: American Health Source Type: news
Researchers develop new method to identify potential stroke therapies
First-of-its-kind study points to uric acid as a promising treatment for further investigation.
Source: National Institutes of Health (NIH) News Releases - September 20, 2023 Category: American Health Source Type: news
Lower SBP Targets After Endovascular Therapy Do Not Meet Futility Criteria
WEDNESDAY, Sept. 20, 2023 -- For patients with acute ischemic stroke undergoing endovascular therapy, lower systolic blood pressure (SBP) targets do not meet prespecified criteria for futility, according to a study published in the Sept. 5 issue of...
Source: Drugs.com - Pharma News - September 20, 2023 Category: Pharmaceuticals Source Type: news
How to improve the description of superior mesenteric artery occlusions in acute mesenteric ischemia: A new computed tomography anatomic segmentation
Acute mesenteric ischemia (AMI) is an intestinal vascular emergency and one of the most severe ischemic syndromes. For stroke or myocardial infarction, arterial segmentations were proposed as early as 1938 and 1975, respectively. These segmentations - used on a daily basis - made it possible to harmonize practices and standardize neurovascular and coronary studies. There is no such standardization in AMI, but the vital and functional prognostic challenge is of the same order. In addition, the lack of a standardized description of superior mesenteric artery (SMA) lesions limits the interpretation and comparability of the studies.
Source: Annals of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Lorenzo Garzelli, Iannis Ben Abdallah, Arnaud Tual, Alexandre Nuzzo, Jonathan Cortese Yves Panis, Olivier Corcos, Val érie Vilgrain, Yves Castier, Maxime Ronot Source Type: research
Do the technical features of carotid eversion affect early restenosis? Design of a prospective multicenter study
Myointimal hyperplasia restenosis remains a concern following carotid endarterectomy. It occurs in about 6% of people. The 3-year rate of stroke after restenosis is 5.2%. Several risk factors for restenosis have been identified, such as smoking, hypertension, female gender, diabetes, dyslipidemia, or small carotid diameter. The primary objective of this prospective multicenter study was to determine whether the technical characteristics of the eversion technique influence the 1-year rate of restenosis.
Source: Annals of Vascular Surgery - September 20, 2023 Category: Surgery Authors: Cl émentine Crepon, Cindy Vannier, Bahaa Nasr, Tom Le Corvec, Robert Martinez, Gregory Dessertenne, Christophe Robin, Nicolas Bague, Eva Deveze, Gautier Haupert, Jean Picquet Source Type: research
Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research
Transport use limitations and its association with social participation among patients with stroke living in rural India
CONCLUSIONS: Independent use of different modes of transport, particularly public transportation, reduced among rural Indian stroke survivors. These transport limitations are significantly associated with reduced social participation, highlighting the need for interventions to improve accessibility and fostering greater community engagement for stroke survivors in this population.IMPLICATIONS FOR REHABILITATIONLimited transportation access limits social participation for stroke survivors in rural India.Study results show a significant decrease in independent transport use among stroke survivors, affecting their social part...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Kajal Chavda V Prakash Source Type: research
Standardized circuit class group training versus individualized goal-directed group training to improve upper limb function in stroke survivors during in-patient rehabilitation: a pragmatic trial
CONCLUSIONS: A standardized training could reduce the mental workload for therapists, but patients seemed less engaged. A combination of both might be most beneficial.Trial registration: Dutch Trial Register: NL8844 and NL9471IMPLICATIONS FOR REHABILITATIONProviding a standardized training program after stroke reduces therapists' mental workload.Individualized goal-directed group training results in the best achievement of rehabilitation goals.A combination of standardized and individual training would use best of both intervention modalities.Patients should be involved in the co-creation developing process of training pro...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: S G Rozevink C M Beerepoot C K van der Sluis J M Hijmans Source Type: research
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Neuroprotective effects of oxytocin against ischemic stroke in rats by blocking glutamate release and CREB-mediated DNA hypermethylation
Biomed Pharmacother. 2023 Sep 18;167:115520. doi: 10.1016/j.biopha.2023.115520. Online ahead of print.ABSTRACTGlutamate plays a crucial role in cognitive impairments after ischemic stroke. There is a scarcity of information about how glutamate-induced activation of cAMP-response element binding (CREB) signaling pathway regulates both the negative and positive regulators of synaptic plasticity. Recent studies have demonstrated the involvement of prominent epigenetic repressors, such as MeCP2 and DNMTs, in stroke. Neuroprotective effects of oxytocin against ischemia have been previously reported, while the underlying mechani...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2023 Category: Drugs & Pharmacology Authors: Xin-Yu Fan Guang Shi Yun-Peng Zhao Jing-Jing Yang Juan Feng Source Type: research
Transport use limitations and its association with social participation among patients with stroke living in rural India
CONCLUSIONS: Independent use of different modes of transport, particularly public transportation, reduced among rural Indian stroke survivors. These transport limitations are significantly associated with reduced social participation, highlighting the need for interventions to improve accessibility and fostering greater community engagement for stroke survivors in this population.IMPLICATIONS FOR REHABILITATIONLimited transportation access limits social participation for stroke survivors in rural India.Study results show a significant decrease in independent transport use among stroke survivors, affecting their social part...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: Kajal Chavda V Prakash Source Type: research
Standardized circuit class group training versus individualized goal-directed group training to improve upper limb function in stroke survivors during in-patient rehabilitation: a pragmatic trial
CONCLUSIONS: A standardized training could reduce the mental workload for therapists, but patients seemed less engaged. A combination of both might be most beneficial.Trial registration: Dutch Trial Register: NL8844 and NL9471IMPLICATIONS FOR REHABILITATIONProviding a standardized training program after stroke reduces therapists' mental workload.Individualized goal-directed group training results in the best achievement of rehabilitation goals.A combination of standardized and individual training would use best of both intervention modalities.Patients should be involved in the co-creation developing process of training pro...
Source: Disability and Rehabilitation - September 20, 2023 Category: Rehabilitation Authors: S G Rozevink C M Beerepoot C K van der Sluis J M Hijmans Source Type: research
Low value of inherited thrombophilia testing among patients with stroke or transient ischemic attack: A three-year retrospective study
Inherited thrombophilia testing in the acute inpatient setting is controversial and expensive, and rarely changes clinical management. We evaluated ordering patterns and results of inpatient inherited thrombophilia testing for patients who presented with an isolated acute ischemic stroke or transient ischemic attack (TIA) without concurrent venous thromboembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Shyam Majmundar, Sameep Thapa, Elan S. Miller, Rodney Bell, Robin Dharia, Diana Tzeng, Shaista Alam, Ruben Rhoades Source Type: research
Organized multi-disciplinary stroke team care improves acute stroke outcomes in resource limited settings; Results of a retrospective study from a Nigerian tertiary hospital
Evidence for the impact of organized stroke multidisciplinary teams (MDTs) on outcomes in Africa is sparse.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Olaleye Adeniji, Osi Adeleye, Joshua Akinyemi, Folajimi Otubogun, Gabriel Ogunde, Mayowa Ogunrombi, Deborah Adesina, Ahmed Wahab, Michael Ogunlana, Talayo Alimi, Rufus Akinyemi Source Type: research
